DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Gad1 and Ddc

DIOPT Version :9

Sequence 1:	NP_001261396.1	Gene:	Gad1 / 38484	FlyBaseID:	FBgn0004516	Length:	510	Species:	Drosophila melanogaster
Sequence 2:	NP_001177377.1	Gene:	Ddc / 13195	MGIID:	94876	Length:	480	Species:	Mus musculus

Alignment Length:	513	Identity:	132/513 - (25%)
Similarity:	205/513 - (39%)	Gaps:	74/513 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly    32 ETREFLLK---VIDVLLDFVKATNDRNEKVLDFHHPEDMKRLLDLDVPDRALPLQQLIEDCATTL 93
            ::|||..:   ::|.:.|::.....|  .|.....|..::.|:....|......:.:|:|....:
Mouse     2 DSREFRRRGKEMVDYIADYLDGIEGR--PVYPDVEPGYLRPLIPATAPQEPETYEDIIKDIEKII 64

  Fly    94 KYQVKTGH-PHFFNQLSNGLDLISMAGEWLTATANTNMFTYEIAPVFILMENVV---LTKMRE-- 152
            ...|...| |:||..........:|..:.|........|::..:|....:|.|:   |.||.|
Mouse    65 MPGVTHWHSPYFFAYFPTASSYPAMLADMLCGAIGCIGFSWAASPACTELETVMMDWLGKMLELP 129

  Fly   153 ---IIGWSG-GDSILAPGGSISNLYAFLAARHKMFPNYK----EHGSVGLPGTLVMFTSDQCHYS 209
               :.|.:| |..::....|.:.|.|.||||.|:....:    |.....:...||.:||||.|.|
Mouse   130 EAFLAGRAGEGGGVIQGSASEATLVALLAARTKVIRQLQAASPEFTQAAIMEKLVAYTSDQAHSS 194

  Fly   210 IKSCAAVCGLGTDHCIVVPSDEHGKMITSELERLILERKAKGDIPFFVNATAGTTVLGAFDDINT 274
            ::....:.|:...   .||||.:..|..|.|...:...||.|.|||||.||.|||...:||::..
Mouse   195 VERAGLIGGIKLK---AVPSDGNFSMRASALREALERDKAAGLIPFFVVATLGTTSCCSFDNLLE 256

  Fly   275 IADICQKYNCWMHIDAAWGGGLLMSRKHRHPRFTGVERADSVTWNPHKLMGALLQCSTIHFKEDG 339
            :..||.:...|:|||||:.|...:..:.|: ...|||.|||..:||||.:.....||.:..|...
Mouse   257 VGPICNQEGVWLHIDAAYAGSAFICPEFRY-LLNGVEFADSFNFNPHKWLLVNFDCSAMWVKRRT 320

  Fly   340 LLISCNQMSAEYL--------FMTDKQYDISYDTGDKVIQCGRHNDIFKLWLQWRAKGTEGFEQQ 396
            .|.....|...||        |:||.::        ..|..||.....|:|..:|..|.:|.:..
Mouse   321 DLTGAFNMDPVYLKHSHQDSGFITDYRH--------WQIPLGRRFRSLKMWFVFRMYGVKGLQAY 377

  Fly   397 QDRLMELVQYQLKRIREQSDRFHLILEPECVNVSFWYVPKRLRGVPHDAKKEVELGKICPIIKGR 461
            ..:.:|| .::.:.:..|..||.:     |.                    ||.||.:|..:||.
Mouse   378 IRKHVEL-SHEFESLVRQDPRFEI-----CT--------------------EVILGLVCFRLKGS 416

  Fly   462 MMQKGTLM--------VGYQPDDRRPNF-FRSIISSAAVNEADVDFMLDEIHRLGDDL 510
            .....||:        :...|...|..| .|..:.:..|..|.|....:.|..|...:
Mouse   417 NELNETLLQRINSAKKIHLVPCRLRDKFVLRFAVCARTVESAHVQLAWEHISDLASSV 474

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Gad1	NP_001261396.1	Pyridoxal_deC	64..434	CDD:395219	107/391 (27%)
Ddc	NP_001177377.1	Pyridoxal_deC	35..414	CDD:395219	112/416 (27%)
Ddc	NP_001177377.1	2 X approximate tandem repeats	58..178		28/119 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0076
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810