Protein Alignment Gad1 and Tdc2

DIOPT Version :10

• Sequence 1: NP_523914.2
• Gene: Gad1 / 38484
• FlyBaseID: FBgn0004516
• Length: 510
• Species: Drosophila melanogaster
• Sequence 2: XP_308519.3
• Gene: Tdc2 / 1269865
• VectorBaseID: AGAMI1_013508
• Length: 642
• Species: Anopheles gambiae
• Alignment Length: 508
• Identity: 119/508 - (23%)
• Similarity: 216/508 - (42%)
• Gaps: 78/508 - (15%)

  Fly    32 ETREFL---LKVIDVLLDFVKATNDRNEKVLDFHHPEDMKRLLDLDVPDRALPLQQLIEDCATTL 93
            :::||.   .::::.:.::::....|  :|.....|..:|..|..:.|:...|.:::::|    :
Mosquito     2 DSKEFRRRGTEMVEYICNYLETLEQR--RVTPCVEPGYLKHQLPDEAPEEPEPWEKIMQD----V 60

  Fly    94 KYQVKTG-----HPHFFNQLSNGLDLISMAGEWLTATANTNMFTYEIAPVFILMENVVLTKMREI 153
            :.::..|     ||.|.....:|....|:.|:.|:.......|::..:|....:|.:||..:.:.
Mosquito    61 EDKIMPGVTHWQHPRFHAYFPSGNSFPSILGDMLSDGIGCIGFSWAASPACTELETIVLDWLGKA 125

  Fly   154 IGWSGGDSILA------PGGSISN------LYAFLAARHKMFPNYK-EHGSV---GLPGTLVMFT 202
            ||..  ||.||      .||.|..      |...||||.:.....| :|..|   .|...|:.:.
Mosquito   126 IGLP--DSFLALKPGSRGGGVIQTSASECVLVTMLAARAQAIKYLKQQHPFVEEGHLLSKLMAYC 188

  Fly   203 SDQCHYSIKSCAAVCGLGTDHCIVVPSDEHGKMITSELERLILERKAKGDIPFFVNATAGTTVLG 267
            |.:.|..::..|.:..:   ...::..||...:....|.:.:.|.:.:|.|||||:.|.|||...
Mosquito   189 SKEAHSCVEKAAMISFV---KLRILEPDEKCCLRADTLIKAMEEDEQQGLIPFFVSTTLGTTGSC 250

  Fly   268 AFDDINTIADICQKY-NCWMHIDAAWGGGLLMSRKHRHPRFTGVERADSVTWNPHKLMGALLQCS 331
            ||||:..|.:..|:: :.|:|:|||:.|...:..:.:: ...|::.|||...||:|.:.....||
Mosquito   251 AFDDLAEIGEALQRFPSVWLHVDAAYAGNAFICPELKY-LLKGIQYADSFNTNPNKWLLTNFDCS 314

  Fly   332 TIHFKEDGLLISCNQMSAEYLFMTDKQYDISYDTGDKVIQCGRHNDIFKLWLQWRAKGTEGFEQQ 396
            |:..::...|.|.  :..:.|::.....|.:.|.....:...|.....|||...|:.|..|
Mosquito   315 TLWVRDRIRLTSA--LVVDPLYLQHGYTDSAIDYRHWGVPLSRRFRSLKLWFVLRSYGISG---- 373

  Fly   397 QDRLMELVQYQLKRIREQSDRFHLILEPECVNVSFWYVPKRLRGVPHDAKKEVELGKICPIIKG- 460
                   :|..::...|.:.||..::               |:....:...||.||.:|..:||
Mosquito   374 -------LQAYIRHHIELAKRFEALV---------------LKDSRFEVCNEVRLGLVCFRLKGT 416

  Fly   461 -RMMQK--------GTL-MVGYQPDDRRPNFFRSIISSAAVNEADVDFMLDEI 503
             |:.:|        |.| ||....:|.....|.::..:|.|.  |:|:..|.|
Mosquito   417 DRINEKLLSSINASGKLHMVPASVNDTYVIRFCAVAQNAKVE--DIDYAWDVI 467

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Gad1	NP_523914.2	Pyridoxal_deC	64..434	CDD:395219	93/391 (24%)
Tdc2	XP_308519.3	Pyridoxal_deC	35..414	CDD:395219	99/416 (24%)