DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Gad1 and gad1a

DIOPT Version :9

Sequence 1:	NP_001261396.1	Gene:	Gad1 / 38484	FlyBaseID:	FBgn0004516	Length:	510	Species:	Drosophila melanogaster
Sequence 2:	XP_002663350.1	Gene:	gad1a / 100329827	ZFINID:	ZDB-GENE-070912-472	Length:	591	Species:	Danio rerio

Alignment Length:	502	Identity:	275/502 - (54%)
Similarity:	364/502 - (72%)	Gaps:	13/502 - (2%)

- Green bases have known domain annotations that are detailed below.

  Fly    17 LTAYDLMPTTVTAGPE-TREFLLKVIDVLLDFVKATNDRNEKVLDFHHPEDMKRLLD---LDVPD 77
            |.|.||:|  ...|.| |.:|||:|:::|.::|:.|.||:.||||||||..:...::   |::.|
Zfish    95 LYARDLLP--AKNGEEYTMQFLLEVVEILTNYVRKTFDRSTKVLDFHHPHQLLEGMEGFNLELCD 157

  Fly    78 RALPLQQLIEDCATTLKYQVKTGHPHFFNQLSNGLDLISMAGEWLTATANTNMFTYEIAPVFILM 142
            :...|:|::.||..||||.|:||||.||||||:|||:|.:||||||:|||||||||||||||:||
Zfish   158 QPESLEQILVDCRDTLKYGVRTGHPRFFNQLSSGLDIIGLAGEWLTSTANTNMFTYEIAPVFVLM 222

  Fly   143 ENVVLTKMREIIGWSG--GDSILAPGGSISNLYAFLAARHKMFPNYKEHGSVGLPGTLVMFTSDQ 205
            |.:.|.|||||:||..  ||.|.:|||:|||:|:.:.||:|.:|..|..|....| .||:|||:.
Zfish   223 EQLTLKKMREIVGWPNGEGDGIFSPGGAISNMYSVMVARYKHYPEIKIKGMAAAP-RLVLFTSEH 286

  Fly   206 CHYSIKSCAAVCGLGTDHCIVVPSDEHGKMITSELERLILERKAKGDIPFFVNATAGTTVLGAFD 270
            .|||||..:||.|.||::.|::.:||.|::|.::||..:::.|.||.:|.|||||||:||.||||
Zfish   287 SHYSIKKASAVLGFGTENLILLRTDERGRVIPADLEAKVIDAKQKGFVPMFVNATAGSTVYGAFD 351

  Fly   271 DINTIADICQKYNCWMHIDAAWGGGLLMSRKHRHPRFTGVERADSVTWNPHKLMGALLQCSTIHF 335
            .||.|||||:|||.|:|:|.||||||||||||:| :.:|:|||:||||||||:||..||||.|..
Zfish   352 PINEIADICEKYNMWLHVDGAWGGGLLMSRKHKH-KLSGIERANSVTWNPHKMMGVPLQCSAILV 415

  Fly   336 KEDGLLISCNQMSAEYLFMTDKQYDISYDTGDKVIQCGRHNDIFKLWLQWRAKGTEGFEQQQDRL 400
            :|.|||..||.|.|.|||..|||||::||||||.||||||.||||.||.|::|||.|||:..||.
Zfish   416 REKGLLQGCNSMCAGYLFQPDKQYDVTYDTGDKAIQCGRHVDIFKFWLMWKSKGTTGFEKHIDRC 480

  Fly   401 MELVQYQLKRIREQSDRFHLIL--EPECVNVSFWYVPKRLRGVPHDAKKEVELGKICPIIKGRMM 463
            :||.:|...:|:.: :.:.::.  ||:..||.|||:|..||.:|...:|...|.|:.|.||..||
Zfish   481 LELSEYLYHKIKNR-EGYEMVFQGEPQHTNVCFWYIPPSLRLLPDGEEKRHRLHKVAPKIKALMM 544

  Fly   464 QKGTLMVGYQPDDRRPNFFRSIISSAAVNEADVDFMLDEIHRLGDDL 510
            :.||.||||||...:.||||.::|:.||..:|:||::|||.|||.||
Zfish   545 ECGTTMVGYQPQGEKVNFFRMVVSNPAVTRSDIDFLIDEIERLGQDL 591

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Gad1	NP_001261396.1	Pyridoxal_deC	64..434	CDD:395219	212/376 (56%)
gad1a	XP_002663350.1	Pyridoxal_deC	141..515	CDD:278699	212/376 (56%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170578191
Domainoid	1	1.000	453	1.000	Domainoid score	I485
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	564	1.000	Inparanoid score	I1042
OMA	1	1.010	-	-		QHG62386
OrthoDB	1	1.010	-	-		D162307at33208
OrthoFinder	1	1.000	-	-		FOG0000667
OrthoInspector	1	1.000	-	-		otm24221
orthoMCL	1	0.900	-	-		OOG6_100596
Panther	1	1.100	-	-	O	PTHR45677
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X464
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	13	12.910