DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Gad1 and gad3

DIOPT Version :9

Sequence 1:	NP_001261396.1	Gene:	Gad1 / 38484	FlyBaseID:	FBgn0004516	Length:	510	Species:	Drosophila melanogaster
Sequence 2:	NP_001083039.2	Gene:	gad3 / 100038790	ZFINID:	ZDB-GENE-070424-80	Length:	546	Species:	Danio rerio

Alignment Length:	512	Identity:	282/512 - (55%)
Similarity:	362/512 - (70%)	Gaps:	20/512 - (3%)

- Green bases have known domain annotations that are detailed below.

  Fly    14 TGKLT-------AYDLMPTTVTAGPE-TREFLLKVIDVLLDFVKATNDRNEKVLDFHHPEDMKRL 70
            :|::|       :.||:|  ...|.| |:.||.:::::||.::..:..|:.||||||:|..:...
Zfish    40 SGRVTHDFSCIHSKDLLP--AEDGEEATKHFLQELVNILLAYISKSLKRSTKVLDFHYPHQLNEG 102

  Fly    71 LD---LDVPDRALPLQQLIEDCATTLKYQVKTGHPHFFNQLSNGLDLISMAGEWLTATANTNMFT 132
            |:   |::||:...|:||:.||..||||.||||||.||||||.|||::.:||||||:||||||||
Zfish   103 LEGFSLELPDQPDNLEQLLVDCRDTLKYGVKTGHPRFFNQLSTGLDIVGLAGEWLTSTANTNMFT 167

  Fly   133 YEIAPVFILMENVVLTKMREIIGW--SGGDSILAPGGSISNLYAFLAARHKMFPNYKEHGSVGLP 195
            |||:|||||||.|||.||..||||  ..||.|..||||:||||:.|.||..:||..|.||...:|
Zfish   168 YEISPVFILMEEVVLRKMHTIIGWPEEDGDGIFCPGGSMSNLYSVLLARFHLFPAVKTHGMCAIP 232

  Fly   196 GTLVMFTSDQCHYSIKSCAAVCGLGTDHCIVVPSDEHGKMITSELERLILERKAKGDIPFFVNAT 260
             .|.||||...|||||..|||.|:||::.|||..||.||||:|||...|.|.|:||.:||:||||
Zfish   233 -RLAMFTSAHSHYSIKKSAAVLGIGTENVIVVRCDERGKMISSELNSSIEEAKSKGLVPFYVNAT 296

  Fly   261 AGTTVLGAFDDINTIADICQKYNCWMHIDAAWGGGLLMSRKHRHPRFTGVERADSVTWNPHKLMG 325
            |||||.||||.::.|||||:.:..|||:|||||||||:|.||| .:..|:|||.||||||||:||
Zfish   297 AGTTVYGAFDPLHKIADICEHHGLWMHVDAAWGGGLLLSNKHR-VKLHGIERAHSVTWNPHKMMG 360

  Fly   326 ALLQCSTIHFKEDGLLISCNQMSAEYLFMTDKQYDISYDTGDKVIQCGRHNDIFKLWLQWRAKGT 390
            ..||||||..|..|||..|||:.|||||..||.|::|||||||.||||||.|||||||.|:|||:
Zfish   361 VPLQCSTILVKRKGLLQQCNQLCAEYLFQPDKHYEVSYDTGDKSIQCGRHVDIFKLWLMWKAKGS 425

  Fly   391 EGFEQQQDRLMELVQYQLKRIREQSDRFHLIL--EPECVNVSFWYVPKRLRGVPHDAKKEVELGK 453
            ||||.|.:..:|..:|...:::.::| |.|:.  :||..||.|||:|||::.:|...::|.||..
Zfish   426 EGFESQVNHCLENAEYLYYKLKRRTD-FQLVFKGKPEHSNVCFWYLPKRVQNIPLGPEREKELHM 489

  Fly   454 ICPIIKGRMMQKGTLMVGYQPDDRRPNFFRSIISSAAVNEADVDFMLDEIHRLGDDL 510
            :.|.||.:||::|..|:||||.:.:.||||.:.|:.|....||||:||||.|||.:|
Zfish   490 VAPKIKTKMMEEGFTMIGYQPLEDKVNFFRCVFSNPATQREDVDFLLDEIVRLGCEL 546

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Gad1	NP_001261396.1	Pyridoxal_deC	64..434	CDD:395219	226/376 (60%)
gad3	NP_001083039.2	Pyridoxal_deC	96..469	CDD:278699	225/375 (60%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170578189
Domainoid	1	1.000	453	1.000	Domainoid score	I485
eggNOG	1	0.900	-	-		E1_COG0076
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	564	1.000	Inparanoid score	I1042
OMA	1	1.010	-	-		QHG62386
OrthoDB	1	1.010	-	-		D162307at33208
OrthoFinder	1	1.000	-	-		FOG0000667
OrthoInspector	1	1.000	-	-		otm24221
orthoMCL	1	0.900	-	-		OOG6_100596
Panther	1	1.100	-	-	LDO	PTHR45677
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X464
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	15	14.770