DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Rcd5 and mcrs1

DIOPT Version :9

Sequence 1:	NP_647852.1	Gene:	Rcd5 / 38478	FlyBaseID:	FBgn0263832	Length:	578	Species:	Drosophila melanogaster
Sequence 2:	NP_001016780.2	Gene:	mcrs1 / 549534	XenbaseID:	XB-GENE-5732599	Length:	453	Species:	Xenopus tropicalis

Alignment Length:	494	Identity:	241/494 - (48%)
Similarity:	308/494 - (62%)	Gaps:	80/494 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly    89 KRRSSSRTIKRKRFDDEIVEYNIAVPTNR----SGTDANR--SSRPRTTSQNYPALVGVPHTTLA 147
            |||||||.||||:||||:||.::|..|:|    ||.:..|  .|.|.::.:.......:
Frog    34 KRRSSSRFIKRKKFDDELVESSLAKSTSRARGPSGGEPGRYSGSEPSSSEKKKQVCKAI------ 92

  Fly   148 PLNIPTSTPQTPLSVDSLLPGTPSTVASLSLATPTTPAPLATPLPVAPIVTAVAHPKPPAMERST 212
                                              |||||   |.| ||
Frog    93 ----------------------------------TTPAP---PSP-AP----------------- 102

  Fly   213 TSERRSRPVRPASKKAQRRNGRPMGQMATKDLGRWKPIDDLALIIGIQQTNDLRIIHRGVKFSCK 277
                     .|:..|..:::.:|:  ..|||||||||.|||.||..:.|||||..:|.||||||:
Frog   103 ---------SPSIAKRIKKSKQPL--QVTKDLGRWKPADDLLLINTVLQTNDLHAVHLGVKFSCR 156

  Fly   278 FTLQELQQRWYALLYEPAVSRIAVSAIRNLHPELVESVQRKALYSVQEEDLLGTIKSSEQPKLEQ 342
            |||.|:|:|||||||:|.:|::|..|||.||||::.::|.:.|:|..||.||.|:.|:.||.|:.
Frog   157 FTLNEIQERWYALLYDPVISKLACQAIRQLHPEVIAAIQSRVLFSKAEEQLLSTVSSASQPTLDT 221

  Fly   343 FQELLDKNASVFYCARTAKSLQNHWLLLKQYTLLPDQSVKPIYGTDQQPLSFSDAEDQIFEHDLN 407
            ||:||:|:..|||.:|||||||.||.|:|||.||.||:|:|:...| |.|:||||||.:.:..|.
Frog   222 FQDLLNKHPEVFYMSRTAKSLQVHWQLMKQYYLLEDQTVQPLPKGD-QVLNFSDAEDMLDDSKLR 285

  Fly   408 EPRDEALEMERALADRRNKRNIRLLENELSRWAVLVDSVLSPTAASEFDNQTLACLCGRHVRYLM 472
            |.|||.||.|..:||||.||.||.||.||:||.|||||: :..::.:||.||||.|.||.|||||
Frog   286 ETRDEVLEHELTVADRRQKREIRQLEQELNRWQVLVDSI-TGMSSPDFDTQTLAVLRGRMVRYLM 349

  Fly   473 RSKEITFGRDAKDCVVDVDLGLEGPAAKISRRQGTIKLRSNGDFFIANEGKRAIFIDGTPLLSAN 537
            ||:|||.||..||..:||||.|||||.||||:||.|||::||||||||||:|||:|||.|:|..:
Frog   350 RSREITLGRATKDNQIDVDLSLEGPAWKISRKQGVIKLKNNGDFFIANEGRRAIYIDGRPVLPGS 414

  Fly   538 KARLGHNCTVEISGLRFTFLVNYELINAIRQESAKTSNP 576
            |.:|.||..||||||||.||:|.:||:.|:.|:||...|
Frog   415 KWKLSHNSVVEISGLRFVFLINQDLISLIKAEAAKVIQP 453

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Rcd5	NP_647852.1	MCRS_N	246..444	CDD:290064	115/197 (58%)
Rcd5	NP_647852.1	FHA	465..559	CDD:238017	66/93 (71%)
mcrs1	NP_001016780.2	MCRS_N	125..322	CDD:372565	115/197 (58%)
mcrs1	NP_001016780.2	FHA	336..436	CDD:238017	70/99 (71%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	239	1.000	Domainoid score	I2248
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	1	1.000	-	-		H4622
Inparanoid	1	1.050	420	1.000	Inparanoid score	I1759
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1091011at2759
OrthoFinder	1	1.000	-	-		FOG0005081
OrthoInspector	1	1.000	-	-		oto105501
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3176
SonicParanoid	1	1.000	-	-		X4708
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	8	8.090