DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Rcd5 and Mcrs1

DIOPT Version :9

Sequence 1:	NP_647852.1	Gene:	Rcd5 / 38478	FlyBaseID:	FBgn0263832	Length:	578	Species:	Drosophila melanogaster
Sequence 2:	NP_001013124.1	Gene:	Mcrs1 / 300222	RGDID:	1311607	Length:	462	Species:	Rattus norvegicus

Alignment Length:	485	Identity:	235/485 - (48%)
Similarity:	302/485 - (62%)	Gaps:	71/485 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly    89 KRRSSSRTIKRKRFDDEIVEYNIAVPTNR-SGTDANRSSRPRTTSQNYPALVGVPHTTLAPLNIP 152
            |||||||.||||:||||:||.::|..:.| .|..:..|.|...:.                   |
  Rat    44 KRRSSSRFIKRKKFDDELVESSLAKSSTRVKGAGSVESGRCSGSE-------------------P 89

  Fly   153 TSTPQTPLSVDSLLPGTPSTVASLSLATPTTPAPLATPLPVAPIVTAVAHPKPPAMERSTTSERR 217
            :|:.:..:   |..|.||         .|.:|||
  Rat    90 SSSEKKKV---SKAPSTP---------VPPSPAP------------------------------- 111

  Fly   218 SRPVRPASKKAQRRNGRPMGQMATKDLGRWKPIDDLALIIGIQQTNDLRIIHRGVKFSCKFTLQE 282
                .|...|..:::.:|:  ..|||||||||.|||.||..:.|||||..:|.||||||:|||:|
  Rat   112 ----TPGLTKRVKKSKQPL--QVTKDLGRWKPADDLLLINAVLQTNDLTSVHLGVKFSCRFTLRE 170

  Fly   283 LQQRWYALLYEPAVSRIAVSAIRNLHPELVESVQRKALYSVQEEDLLGTIKSSEQPKLEQFQELL 347
            :|:|||||||:|.:|::|..|:|.||||.:.::|.|||:|..||.||..:.|:.||.||.||:||
  Rat   171 VQERWYALLYDPVISKLACQAMRQLHPEAIAAIQSKALFSKAEEQLLSKVGSTSQPTLETFQDLL 235

  Fly   348 DKNASVFYCARTAKSLQNHWLLLKQYTLLPDQSVKPIYGTDQQPLSFSDAEDQIFEHDLNEPRDE 412
            .::...||.|||||:||.||.|:|||.||.||:|:|:...| |.|:||||||.|.:.:|.:.|||
  Rat   236 HRHPDAFYLARTAKALQAHWQLMKQYYLLEDQTVQPLPKGD-QVLNFSDAEDLIDDSELKDMRDE 299

  Fly   413 ALEMERALADRRNKRNIRLLENELSRWAVLVDSVLSPTAASEFDNQTLACLCGRHVRYLMRSKEI 477
            .||.|..:||||.||.||.||.||.:|.|||||: :..::.:|||||||.|.||.|||||||:||
  Rat   300 VLEHELTVADRRQKREIRQLEQELHKWQVLVDSI-TGMSSPDFDNQTLAVLRGRMVRYLMRSREI 363

  Fly   478 TFGRDAKDCVVDVDLGLEGPAAKISRRQGTIKLRSNGDFFIANEGKRAIFIDGTPLLSANKARLG 542
            |.||..||..:||||.|||||.||||:||.|||::||||||||||:|.|:|||.|:|..:|.||.
  Rat   364 TLGRATKDNQIDVDLSLEGPAWKISRKQGVIKLKNNGDFFIANEGRRPIYIDGRPVLCGSKWRLS 428

  Fly   543 HNCTVEISGLRFTFLVNYELINAIRQESAK 572
            :|..|||:.|||.||:|.:||..||.|:||
  Rat   429 NNSVVEIASLRFVFLINQDLIALIRAEAAK 458

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Rcd5	NP_647852.1	MCRS_N	246..444	CDD:290064	113/197 (57%)
Rcd5	NP_647852.1	FHA	465..559	CDD:238017	63/93 (68%)
Mcrs1	NP_001013124.1	MCRS_N	134..331	CDD:290064	113/197 (57%)
Mcrs1	NP_001013124.1	FHA	345..445	CDD:238017	67/99 (68%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166335397
Domainoid	1	1.000	231	1.000	Domainoid score	I2352
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H4622
Inparanoid	1	1.050	398	1.000	Inparanoid score	I1886
OMA	1	1.010	-	-		QHG48167
OrthoDB	1	1.010	-	-		D1091011at2759
OrthoFinder	1	1.000	-	-		FOG0005081
OrthoInspector	1	1.000	-	-		oto98807
orthoMCL	1	0.900	-	-		OOG6_106192
Panther	1	1.100	-	-	LDO	PTHR13233
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X4708
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	14	13.910