Protein Alignment Rcd5 and MCRS1

DIOPT Version :10

• Sequence 1: NP_647852.1
• Gene: Rcd5 / 38478
• FlyBaseID: FBgn0263832
• Length: 578
• Species: Drosophila melanogaster
• Sequence 2: NP_001012300.1
• Gene: MCRS1 / 10445
• HGNCID: 6960
• Length: 475
• Species: Homo sapiens
• Alignment Length: 489
• Identity: 237/489 - (48%)
• Similarity: 302/489 - (61%)
• Gaps: 79/489 - (16%)

  Fly    89 KRRSSSRTIKRKRFDDEIVEYNIAVPTNR----SGTDANRSSRPRTTSQNYPALVGVPHTTLAPL 149
            |||||||.||||:||||:||.::|..:.|    ||.:..|.|...
Human    57 KRRSSSRFIKRKKFDDELVESSLAKSSTRAKGASGVEPGRCSGSE-------------------- 101

  Fly   150 NIPTSTPQTPLSVDSLLPGTPSTVASLSLATPTTPAPLATPLPVAPIVTAVAHPKP-PAMERSTT 213
              |:|:.:..:|                 ..|:||.|                |.| ||
Human   102 --PSSSEKKKVS-----------------KAPSTPVP----------------PSPAPA------ 125

  Fly   214 SERRSRPVRPASKKAQRRNGRPMGQMATKDLGRWKPIDDLALIIGIQQTNDLRIIHRGVKFSCKF 278
                     |...|..:::.:|:  ..|||||||||.|||.||..:.|||||..:|.||||||:|
Human   126 ---------PGLTKRVKKSKQPL--QVTKDLGRWKPADDLLLINAVLQTNDLTSVHLGVKFSCRF 179

  Fly   279 TLQELQQRWYALLYEPAVSRIAVSAIRNLHPELVESVQRKALYSVQEEDLLGTIKSSEQPKLEQF 343
            ||:|:|:|||||||:|.:|::|..|:|.||||.:.::|.|||:|..||.||..:.|:.||.||.|
Human   180 TLREVQERWYALLYDPVISKLACQAMRQLHPEAIAAIQSKALFSKAEEQLLSKVGSTSQPTLETF 244

  Fly   344 QELLDKNASVFYCARTAKSLQNHWLLLKQYTLLPDQSVKPIYGTDQQPLSFSDAEDQIFEHDLNE 408
            |:||.::...||.|||||:||.||.|:|||.||.||:|:|:...| |.|:||||||.|.:..|.:
Human   245 QDLLHRHPDAFYLARTAKALQAHWQLMKQYYLLEDQTVQPLPKGD-QVLNFSDAEDLIDDSKLKD 308

  Fly   409 PRDEALEMERALADRRNKRNIRLLENELSRWAVLVDSVLSPTAASEFDNQTLACLCGRHVRYLMR 473
            .|||.||.|..:||||.||.||.||.||.:|.|||||: :..::.:|||||||.|.||.||||||
Human   309 MRDEVLEHELMVADRRQKREIRQLEQELHKWQVLVDSI-TGMSSPDFDNQTLAVLRGRMVRYLMR 372

  Fly   474 SKEITFGRDAKDCVVDVDLGLEGPAAKISRRQGTIKLRSNGDFFIANEGKRAIFIDGTPLLSANK 538
            |:|||.||..||..:||||.|||||.||||:||.|||::||||||||||:|.|:|||.|:|..:|
Human   373 SREITLGRATKDNQIDVDLSLEGPAWKISRKQGVIKLKNNGDFFIANEGRRPIYIDGRPVLCGSK 437

  Fly   539 ARLGHNCTVEISGLRFTFLVNYELINAIRQESAK 572
            .||.:|..|||:.|||.||:|.:||..||.|:||
Human   438 WRLSNNSVVEIASLRFVFLINQDLIALIRAEAAK 471

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Rcd5	NP_647852.1	DUF5585	<112..>221	CDD:465521	17/113 (15%)
		MCRS_N	246..444	CDD:463845	113/197 (57%)
		FHA_MCRS1	455..559	CDD:438739	71/103 (69%)
MCRS1	NP_001012300.1	MCRS_N	147..344	CDD:463845	113/197 (57%)
		FHA_MCRS1	354..458	CDD:438739	71/103 (69%)