DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG11593 and Jup

DIOPT Version :9

Sequence 1:	NP_001261392.1	Gene:	CG11593 / 38477	FlyBaseID:	FBgn0035488	Length:	484	Species:	Drosophila melanogaster
Sequence 2:	NP_112309.2	Gene:	Jup / 81679	RGDID:	620412	Length:	745	Species:	Rattus norvegicus

Alignment Length:	322	Identity:	74/322 - (22%)
Similarity:	105/322 - (32%)	Gaps:	99/322 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly   139 VKNNLNQCRNKPQDAKVSLLRANSPDILSSESDADVSQY-LAAVESNFQSVSLMPNGNG------ 196
            :.:.:|.|  .|..:...||         .|.|....|| |....:..|.|   |...|
  Rat    26 IHSGVNTC--VPSVSSKGLL---------DEDDTCGRQYTLKKTTTYTQGV---PQSQGDLEYQM 76

  Fly   197 -----KKSKRSTALPG--GEDISSLDSISNHSFDDDEDIEHNLASLSPSSSLIDG-----LDGED 249
                 .|..|....||  |||.|.|.:      ...|....||..|:..|.|:..     ::.:|
  Rat    77 STTARAKRVREAMCPGVSGEDSSLLLA------TQVEGQTTNLQRLAEPSQLLKSAIVHLINYQD 135

  Fly   250 DDDDCEGPELLPD-----HDDDLELDLEFGLATTPTPNAPASATAASTLPQYTAAEERRDSRNWQ 309
            |.:  .....||:     :|:|..:..:..:.........||..|....||..||..|
  Rat   136 DAE--LATRALPELTKLLNDEDPVVVTKAAMIVNQLSKKEASRRALMGSPQLVAAVVR------- 191

  Fly   310 KITLPDGRTREID-MRVIEPYKRVLSH--GGYL---KSGGQNAIVIFCACHLPDRSRADYSYVMD 368
              |:.:  |.::| .|........|||  .|.|   ||||..|:|..            .|..::
  Rat   192 --TMQN--TSDLDTARCTTSILHNLSHHREGLLAIFKSGGIPALVRM------------LSSPVE 240

  Fly   369 NLFLYVVKTLEQLVTDDYVLIYLHGGS----------------NRRNVPPFPWLKR-CYQLL 413
            ::..|.:.||..|      |:|..|..                |:.| |.|..:.. |.|||
  Rat   241 SVLFYAITTLHNL------LLYQEGAKMAVRLADGLQKMVPLLNKNN-PKFLAITTDCLQLL 295

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG11593	NP_001261392.1	BNIP2	<293..342	CDD:289278	15/54 (28%)
CG11593	NP_001261392.1	CRAL_TRIO_2	345..475	CDD:290435	18/86 (21%)
Jup	NP_112309.2	Interaction with DSC1 and DSG1. /evidence=ECO:0000250	132..297		45/196 (23%)
		armadillo repeat	144..169	CDD:293788	4/24 (17%)
		armadillo repeat	186..212	CDD:293788	7/36 (19%)
		armadillo repeat	221..253	CDD:293788	10/43 (23%)
		Arm	221..253	CDD:395413	10/43 (23%)
		armadillo repeat	261..297	CDD:293788	8/36 (22%)
		ARM 5	298..341
		armadillo repeat	305..338	CDD:293788
		PLN03200	<328..>658	CDD:215629
		ARM	341..381	CDD:214547
		ARM 6	342..381
		armadillo repeat	345..380	CDD:293788
		ARM 7	383..420
		armadillo repeat	393..418	CDD:293788
		ARM 8	423..464
		armadillo repeat	426..464	CDD:293788
		ARM 9	470..510
		armadillo repeat	470..508	CDD:293788
		ARM 10	512..551
		armadillo repeat	515..572	CDD:293788
		Interaction with DSC1. /evidence=ECO:0000250	574..661
		armadillo repeat	577..611	CDD:293788
		armadillo repeat	618..652	CDD:293788
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0572
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900