DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG11593 and prune2

DIOPT Version :9

Sequence 1:	NP_001261392.1	Gene:	CG11593 / 38477	FlyBaseID:	FBgn0035488	Length:	484	Species:	Drosophila melanogaster
Sequence 2:	XP_031757713.1	Gene:	prune2 / 780047	XenbaseID:	XB-GENE-989623	Length:	2384	Species:	Xenopus tropicalis

Alignment Length:	496	Identity:	159/496 - (32%)
Similarity:	238/496 - (47%)	Gaps:	110/496 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly    41 PEKNILKLEQAKQDHDKEELEFKTTSALDNRILRPELLPMEAMPQRHNIIERTLANSHPLMSPTN 105
            ||.:.|.:|:             .:|.:.:|.|..|....|...|.|         |..::...|
Frog  1902 PECHSLYIEE-------------KSSPIVSRRLGSEKKSEEFSEQEH---------SWSIILSQN 1944

  Fly   106 TDSDSEPFQLKKQEKQLPRSNFPDVVPTTETVQVKNNLN---------------QCRNKPQD--- 152
            ..|||.|               .|:....|||.....|.               |.....||
Frog  1945 EASDSSP---------------EDIFSREETVDTGKGLEDTFQLGYSCDKQGGYQIDTGGQDYTE 1994

  Fly   153 --AKVSLLRANSPDILSSESDADVSQYLAAVESNFQSVSL---MPNGNGKKSKRSTALPGGEDIS 212
              ....:.:....||:     |.||..|.    |.||:|:   :|..:|:.:|.         :.
Frog  1995 LEESFEMCKVEERDIV-----AHVSHDLL----NLQSISVHIQLPPQDGELAKY---------LG 2041

  Fly   213 SLDSISNHSFDDDE--DIEHNLASL--SPSSSL-IDG----------------LDGED----DDD 252
            ..:...|.|..|||  ||..:.|.:  .|.:|| ::|                ||..:    .||
Frog  2042 YKEKTENGSILDDEGMDIPLDAAEIRPEPPNSLDLNGSSTRKIKLTAPNINLSLDHSEGSILSDD 2106

  Fly   253 DCEGPELLPDHDDDLEL-DLEFGLATTPTPNAPASATAA----STLPQYTAAEERRDSRNWQKIT 312
            :.:.|:.|..:.|||:. |.......|...:.||...|.    .::.:|||.|||.|:|.|:.:.
Frog  2107 NLDTPDELDINVDDLDTPDEADSFDYTGQDDQPALGEAVQEDFESIQEYTAEEERADNRLWRTVV 2171

  Fly   313 LPDGRTREIDMRVIEPYKRVLSHGGYLKSGGQNAIVIFCACHLPDRSRADYSYVMDNLFLYVVKT 377
            :.:...| |||:||||||:|:|||||. ..|.|||::|.||.|||.||.||:|||:||||||:.|
Frog  2172 IGEQEQR-IDMKVIEPYKKVISHGGYY-GEGVNAIIVFAACFLPDSSRPDYNYVMENLFLYVIST 2234

  Fly   378 LEQLVTDDYVLIYLHGGSNRRNVPPFPWLKRCYQLLDRRLRKSLKHMYLVHPTFWIKSLVWMARP 442
            ||.:|.:||:::||:|.:.||.:|...|:|:|||::||||||:||...:|||:::|::::.:.||
Frog  2235 LELMVAEDYMVVYLNGATPRRKMPGLGWMKKCYQMIDRRLRKNLKSFIIVHPSWFIRTILALTRP 2299

  Fly   443 FVSTKFWRKLVYVKSLEELGMHVVVEKAAIPEKVKQYDAKR 483
            |:|:||..|:.||.:|.||...:.:|...|||.:.:|:..|
Frog  2300 FISSKFSSKIKYVSTLAELSELIPMEYVHIPETIVKYEESR 2340

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG11593	NP_001261392.1	BNIP2	<293..342	CDD:289278	25/48 (52%)
CG11593	NP_001261392.1	CRAL_TRIO_2	345..475	CDD:290435	66/129 (51%)
prune2	XP_031757713.1	BNIP2	2082..2200	CDD:403629	39/119 (33%)
prune2	XP_031757713.1	CRAL_TRIO_2	2202..2338	CDD:404584	68/135 (50%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	156	1.000	Domainoid score	I4122
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	191	1.000	Inparanoid score	I3744
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D330089at33208
OrthoFinder	1	1.000	-	-		FOG0001054
OrthoInspector	1	1.000	-	-		otm48808
Panther	1	1.100	-	-	O	PTHR12112
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R5755
SonicParanoid	1	1.000	-	-		X708
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	10	10.100