DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG11593 and Atcay

DIOPT Version :9

Sequence 1:	NP_001261392.1	Gene:	CG11593 / 38477	FlyBaseID:	FBgn0035488	Length:	484	Species:	Drosophila melanogaster
Sequence 2:	NP_001035280.1	Gene:	Atcay / 362826	RGDID:	1309312	Length:	372	Species:	Rattus norvegicus

Alignment Length:	347	Identity:	120/347 - (34%)
Similarity:	187/347 - (53%)	Gaps:	48/347 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly   158 LRANSPDILSSESDADVSQYL----------AAVESNFQSVSLMPNGNGKKSKRSTALPGGEDIS 212
            ||..:.|:.....|.|:.:.|          ..||.:....|.: |.:|...||.| |...|...
  Rat     8 LRMENVDVRDEWQDEDLPRPLPEDTGEDHLGGTVEDSSSPPSTL-NLSGAHRKRKT-LVAPEINI 70

  Fly   213 SLDS-----ISNHSFDDDEDIEHNLASLSPSSSLIDGLDGEDDDDDCE----GPELLPDHDDDLE 268
            |||.     :|:...|..:|::.|          :|.::..|:.|..|    |.||  :.:||
  Rat    71 SLDQSEGSLLSDDFLDTPDDLDIN----------VDDIETPDETDSLEFLGNGNEL--EWEDD-- 121

  Fly   269 LDLEFGLATTPTPNAPASATAASTLPQYTAAEE--RRDSRNWQKITLPDGRTREIDMRVIEPYKR 331
                     ||...|......::.|....:.|:  ..:.|.|:.:.:.:...| ||:.:|.||.:
  Rat   122 ---------TPVATAKNMPGDSADLFGDGSGEDGSAANGRLWRTVIIGEQEHR-IDLHMIRPYMK 176

  Fly   332 VLSHGGYLKSGGQNAIVIFCACHLPDRSRADYSYVMDNLFLYVVKTLEQLVTDDYVLIYLHGGSN 396
            |::||||. ..|.|||::|.||.|||.|..||.|:|:||||||:.:||.||.:||:::||:|.:.
  Rat   177 VVTHGGYY-GEGLNAIIVFAACFLPDSSSPDYHYIMENLFLYVISSLELLVAEDYMIVYLNGATP 240

  Fly   397 RRNVPPFPWLKRCYQLLDRRLRKSLKHMYLVHPTFWIKSLVWMARPFVSTKFWRKLVYVKSLEEL 461
            ||.:|...|||:||.::||||||:||.:.:|||:::|::::.::|||:|.||..|:.||.|||||
  Rat   241 RRRMPGIGWLKKCYHMIDRRLRKNLKSLIIVHPSWFIRTVLAISRPFISVKFISKIQYVHSLEEL 305

  Fly   462 GMHVVVEKAAIPEKVKQYDAKR 483
            ...:.:|...:|..|.||:.:|
  Rat   306 EQLIPMEHVQLPACVLQYEEQR 327

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG11593	NP_001261392.1	BNIP2	<293..342	CDD:289278	15/50 (30%)
CG11593	NP_001261392.1	CRAL_TRIO_2	345..475	CDD:290435	65/129 (50%)
Atcay	NP_001035280.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..58		11/50 (22%)
		BNIP2	59..187	CDD:289278	39/153 (25%)
		Required for interaction with KLC1. /evidence=ECO:0000250	115..120		2/6 (33%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	125..144		2/18 (11%)
		CRAL_TRIO_2	189..315	CDD:290435	64/125 (51%)
		Mediates interaction with GLS. /evidence=ECO:0000250	190..372		68/138 (49%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	330..372
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166336005
Domainoid	1	1.000	158	1.000	Domainoid score	I4011
eggNOG	1	0.900	-	-		E1_COG0572
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	220	1.000	Inparanoid score	I3469
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D330089at33208
OrthoFinder	1	1.000	-	-		FOG0001054
OrthoInspector	1	1.000	-	-		otm45720
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	LDO	PTHR12112
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X708
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	10	9.900