Protein Alignment CG11593 and Prune2

DIOPT Version :10

• Sequence 1: NP_647851.3
• Gene: CG11593 / 38477
• FlyBaseID: FBgn0035488
• Length: 484
• Species: Drosophila melanogaster
• Sequence 2: XP_006527207.1
• Gene: Prune2 / 353211
• MGIID: 1925004
• Length: 3087
• Species: Mus musculus
• Alignment Length: 630
• Identity: 185/630 - (29%)
• Similarity: 277/630 - (43%)
• Gaps: 195/630 - (30%)

  Fly     6 AESESSPS----ESKMDISETPTDSTGVSP-------LADD--VLPT-APEKNILKLEQAKQ--- 53
            :.:|||||    |.:.|.|::|.......|       |.:|  |:|| .|::..|:.::.||
Mouse  2456 SNNESSPSNIDWEIETDNSDSPAGGDMKPPNGKEILELEEDEKVIPTKGPKQTELEYKEEKQPEQ 2520

  Fly    54 --DHDKEELEFKTTSALDNRILRPEL---------------------LP---------------- 79
              ||....:::...|...:..|:||.                     ||
Mouse  2521 SEDHQVLAVDYILVSHEKDSPLKPEAREARENIPELEQLSIGSRETGLPETQLSGTPDTCQSEFL 2585

  Fly    80 -------MEAMPQRHNIIERTLAN----------SHPLMS--PTNT-DS-------DSEPF---Q 114
                   .|.|....|....:|.|          ||..:.  ||.| ||       ..|||   .
Mouse  2586 NDVKVHSAERMSSSSNHESASLENPAQDQSWMVLSHSEVGDPPTETRDSGPESPGRTPEPFLSLS 2650

  Fly   115 LKKQEK-QLPRSNFP---------------------------DVVPT------TETVQVKNNLN- 144
            |.|..| |:...|.|                           |.|||      .|...:...|:
Mouse  2651 LDKGPKSQVLERNKPLNSLALEEVAGLSSQSRNIERQGQAGLDAVPTQAATHDNEWEMLSPQLSR 2715

  Fly   145 QCRNKPQDAKVSLL---------RANSPDILSSESDADVSQYLAAVESNFQSVSLMPNG------ 194
            :.||.||:.:....         |...|.  |.:...|:         :|:...|.|:.
Mouse  2716 KNRNPPQEMEEETQCPEPGPRKPRLKGPP--SEDEGMDI---------HFEEGVLSPSAADMRPE 2769

  Fly   195 -------NGKKSKRSTALPGGEDISSLDS-----ISNHSFDDDEDIEHNLASLSPSSSLIDGLDG 247
                   ||...:|........:: |||.     :|:.:.|..::|:.|          :|.||.
Mouse  2770 PPNSLDLNGSHPRRIKLTAPNINL-SLDQSEGSILSDDNLDSPDEIDIN----------VDELDT 2823

  Fly   248 EDDDDDCEGPELLPDHDDDLELDLEFGLATTPTPNAPASATAASTLPQYTAAEERRDSRNWQKIT 312
            .|:.|..|    ..:|:|             ||.| .:|...:.::|:|||.|||.|:|.|:.:.
Mouse  2824 PDEADSFE----YTNHED-------------PTAN-KSSGQESESIPEYTAEEEREDNRLWRTVV 2870

  Fly   313 LPDGRTREIDMRVIEPYKRVLSHGGYLKSG----GQNAIVIFCACHLPDRSRADYSYVMDNLFLY 373
            :.:...| |||:|||||:||:||||  .||    |.|||::|.||.|||.|||||.|||:|||||
Mouse  2871 IGEQEQR-IDMKVIEPYRRVISHGG--DSGYYGDGLNAIIVFAACFLPDSSRADYHYVMENLFLY 2932

  Fly   374 VVKTLEQLVTDDYVLIYLHGGSNRRNVPPFPWLKRCYQLLDRRLRKSLKHMYLVHPTFWIKSLVW 438
            |:.|||.:|.:||:::||:|.:.||.:|...|:|:|||::||||||:||...:|||:::|::::.
Mouse  2933 VISTLELMVAEDYMIVYLNGATPRRKMPGLGWMKKCYQMIDRRLRKNLKSFIIVHPSWFIRTILA 2997

  Fly   439 MARPFVSTKFWRKLVYVKSLEELGMHVVVEKAAIPEKVKQYDAKR 483
            :.|||:|:||..|:.||.||.||...:.::...|||.:.:||.::
Mouse  2998 VTRPFISSKFSSKIKYVTSLSELSGLIPMDCIHIPESIIKYDEEK 3042

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG11593	NP_647851.3	BNIP2	<293..342	CDD:463609	25/48 (52%)
		CRAL_TRIO_2	345..475	CDD:463965	67/129 (52%)
Prune2	XP_006527207.1	DHHA2	214..>277	CDD:460719
		BNIP2	2782..2892	CDD:463609	41/139 (29%)
		CRAL_TRIO_2	2904..3041	CDD:463965	70/136 (51%)