Protein Alignment CG11593 and SH3BP1

DIOPT Version :10

• Sequence 1: NP_647851.3
• Gene: CG11593 / 38477
• FlyBaseID: FBgn0035488
• Length: 484
• Species: Drosophila melanogaster
• Sequence 2: NP_061830.3
• Gene: SH3BP1 / 23616
• HGNCID: 10824
• Length: 701
• Species: Homo sapiens
• Alignment Length: 159
• Identity: 39/159 - (24%)
• Similarity: 59/159 - (37%)
• Gaps: 39/159 - (24%)

  Fly   148 NKPQDAKVSLLRANSPDIL-SSESDADVSQYLAAVESNFQSVSLMPNGNGKKSKRSTALPGGEDI 211
            ||...:.::::.  .|::| ..|.:.|.:|..||..|:.|.|.::   ........|..||
Human   416 NKMTPSNIAIVL--GPNLLWPPEKEGDQAQLDAASVSSIQVVGVV---EALIQSADTLFPG---- 471

  Fly   212 SSLDSISNHSFDDDEDIEHNLASLSPSSSLIDGLDGEDDDDDCEGPELLPDHDDDLELDLEFGLA 276
                           ||..|::.|..:.:|      :|...|....|.||.......       |
Human   472 ---------------DINFNVSGLFSAVTL------QDTVSDRLASEELPSTAVPTP-------A 508

  Fly   277 TTPTPNAPASATAASTLPQYTAAEERRDS 305
            |||.| |||.|.|.:......|.:||.:|
Human   509 TTPAP-APAPAPAPAPALASAATKERTES 536

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG11593	NP_647851.3	BNIP2	<293..342	CDD:463609	4/13 (31%)
		CRAL_TRIO_2	345..475	CDD:463965
SH3BP1	NP_061830.3	Interaction with CGNL1. /evidence=ECO:0000269|PubMed:22891260	1..275
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..23
		BAR_SH3BP1	16..272	CDD:153304
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	160..182
		RhoGAP	272..473	CDD:470621	15/80 (19%)
		Interaction with CD2AP. /evidence=ECO:0000269|PubMed:22891260	470..701		26/100 (26%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	496..701		17/49 (35%)
		SH3-binding. /evidence=ECO:0000250|UniProtKB:P55194	616..625