DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG11594 and Shpk

DIOPT Version :9

Sequence 1:	NP_001261391.1	Gene:	CG11594 / 38473	FlyBaseID:	FBgn0035484	Length:	548	Species:	Drosophila melanogaster
Sequence 2:	NP_083307.1	Gene:	Shpk / 74637	MGIID:	1921887	Length:	476	Species:	Mus musculus

Alignment Length:	543	Identity:	112/543 - (20%)
Similarity:	196/543 - (36%)	Gaps:	133/543 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MSSGPFFVGVDVGTGSARAALVAC-----DGRVL----EQAVQTIQTWNPEPGYYNQSSDNIWQS 56
            |:|.|..:|:|:||.|.:|||:..     .|.|:    .:|.:. :|.:...|...:..|  ...
Mouse     1 MASRPVTLGIDLGTTSVKAALLEAAPSLPSGFVVLASCARAARA-ETESAVAGPQGREQD--VTR 62

  Fly    57 ICQVVKKVIGGVDK---SKVKGIGFDATCSLVVLGPQGSPLTVSKSG-------EAEQNIILWMD 111
            |.|.:.:.:..:.:   .:|:|||.......::....|......:.|       .|..:::.|.|
Mouse    63 IIQALNECLDALPRQQLQRVRGIGVSGQMHGILFWKAGQGCEWMEGGPAFVFEPRAVSHLVTWQD 127

  Fly   112 HRAEQETQEINAFKHSLLKYVGG-QVSLEMEVPKLLWLKRNLSQTFGNIWRVFDLPDFL-TWRAT 174
            .|..      ::|..||.|.... .|:.......:.||.:|             .|:|| ::.|.
Mouse   128 GRCN------SSFLASLPKPDSHLSVATGFGCATIFWLLKN-------------SPEFLKSYDAA 173

  Fly   175 GVDTRSLCSVVC-------------KWNY-DAANGSWNKEFLKQADLEELTQNNFEKLGSDVQPP 225
            |.....:.:::|             .|.| :..:.|||.:.|::|...       ..|..|:..|
Mouse   174 GTIQDYVVAMLCGLPRPLMSDQNAASWGYFNTQSQSWNLDTLEKAGFP-------IHLLPDIAEP 231

  Fly   226 GRTVGKGLTAKAAGELGLSAGTVVSTSLIDAHAGALGMFGCRSKESKGADDVQGKMALIAGTSTC 290
            |...|:  |:....|  :..||.|..:|.|..|   .::.|..:.:....::...:.|.|.....
Mouse   232 GSMAGR--TSHTWFE--IPKGTQVGIALGDLQA---SVYSCMGQRTDAVLNISTSVQLAASMPVG 289

  Fly   291 HMSITRKACFAQGVWGPYQDAIIPGYFLN-EGGQSIAGHLLDHVLKSHESYAELKSQLG---EDK 351
            ...:......|...:.||.|....|...: .||..:|..:  |:|      .:..:.||   |:.
Mouse   290 FQPLQTPDPAAPVAFFPYFDRTYLGVAASLNGGNVLATFV--HML------VQWMADLGLEVEES 346

  Fly   352 FIYQHLNKLLPELAAARGLSQVGCLTQDVH--VWPDLHGNR---SPIADPTLRGVITGLDMTRGT 411
            .:|..:.:     |||:        .:|.|  :.|.:.|.|   ..:|..|.   |:..|::.|.
Mouse   347 TVYSRMIQ-----AAAQ--------QKDTHLTITPTVLGERHLPDQLASVTR---ISSSDLSLGH 395

  Fly   412 ESLAIKYLAFVQALAYGTRHIIENLYQYGRAPFQTLLFCG---------GLAKNPLYVQCHADIC 467
            .:.|:            .|.|::||  :...|||.|...|         .|::|.:..|......
Mouse   396 VTRAL------------CRGIVQNL--HSMLPFQQLKEWGVARVVGSGSALSRNEVLKQEVQRAF 446

  Fly   468 NLPALIPDEQEMVLVGAAALGAA 490
            ..|.....:.:      ||.|||
Mouse   447 PFPVCFGQDVD------AAFGAA 463

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG11594	NP_001261391.1	FGGY_YpCarbK_like	5..540	CDD:212663	110/539 (20%)
CG11594	NP_001261391.1	5C_CHO_kinase	6..540	CDD:273552	109/538 (20%)
Shpk	NP_083307.1	FGGY_SHK_like	5..466	CDD:212661	110/539 (20%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0554
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810