DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG11594 and FGGY

DIOPT Version :9

Sequence 1:	NP_001261391.1	Gene:	CG11594 / 38473	FlyBaseID:	FBgn0035484	Length:	548	Species:	Drosophila melanogaster
Sequence 2:	NP_001106882.1	Gene:	FGGY / 55277	HGNCID:	25610	Length:	575	Species:	Homo sapiens

Alignment Length:	592	Identity:	274/592 - (46%)
Similarity:	377/592 - (63%)	Gaps:	63/592 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MSSGP-----FFVGVDVGTGSARAALVACDGRVLEQAVQTIQTWNPEPGYYNQSSDNIWQSICQV 60
            ||.|.     ::|||||||||.|||||...|.:|..|.|.|:.|.|:..::.|||::||.:.|.|
Human     1 MSGGEQKPERYYVGVDVGTGSVRAALVDQSGVLLAFADQPIKNWEPQFNHHEQSSEDIWAACCVV 65

  Fly    61 VKKVIGGVDKSKVKGIGFDATCSLVVLGPQGSPLTVSKSGEAEQNIILWMDHRAEQETQEINAFK 125
            .|||:.|:|.::::|:|||||||||||..|..||.|::.|::.:|:|:|:||||..:...||..|
Human    66 TKKVVQGIDLNQIRGLGFDATCSLVVLDKQFHPLPVNQEGDSHRNVIMWLDHRAVSQVNRINETK 130

  Fly   126 HSLLKYVGGQVSLEMEVPKLLWLKRNLSQTFGNIW----RVFDLPDFLTWRATGVDTRSLCSVVC 186
            ||:|:||||.:|:||:.|||||||.||.:.   .|    ..|||||||:|:||||..|||||:||
Human   131 HSVLQYVGGVMSVEMQAPKLLWLKENLREI---CWDKAGHFFDLPDFLSWKATGVTARSLCSLVC 192

  Fly   187 KWNYDAANGSWNKEFLKQADLEELTQNNFEKLGSDVQPPGRTVGKGLTAKAAGELGLSAGTVVST 251
            ||.|.|..| |:..|.|...||:...:|:.|:|:.|.|||.::|.|||.:||.:|||..|..|:.
Human   193 KWTYSAEKG-WDDSFWKMIGLEDFVADNYSKIGNQVLPPGASLGNGLTPEAARDLGLLPGIAVAA 256

  Fly   252 SLIDAHAGALGMFGCRSKESKGADDVQG------------KMALIAGTSTCHMSITRKACFAQGV 304
            ||||||||.||:.|.         ||:|            ::|:|.|||:|||.|::...|..||
Human   257 SLIDAHAGGLGVIGA---------DVRGHGLICEGQPVTSRLAVICGTSSCHMGISKDPIFVPGV 312

  Fly   305 WGPYQDAIIPGYFLNEGGQSIAGHLLDHVLKSHESYAELK-SQLGEDKFIYQHLNKLLPELAAAR 368
            ||||..|::||::|||||||:.|.|:||:::.|.::.||: ......:.||.:||..|..:..|:
Human   313 WGPYFSAMVPGFWLNEGGQSVTGKLIDHMVQGHAAFPELQVKATARCQSIYAYLNSHLDLIKKAQ 377

  Fly   369 GLSQVGCLTQDVHVWPDLHGNRSPIADPTLRGV------------------------ITGLDMTR 409
               .||.||.|:|||||.||||||:||.||:|:                        :|||.:::
Human   378 ---PVGFLTVDLHVWPDFHGNRSPLADLTLKGMRTTGYLYIPALAALHSPSSLLSPQVTGLKLSQ 439

  Fly   410 GTESLAIKYLAFVQALAYGTRHIIENLYQYGRAPFQTLLFCGGLAKNPLYVQCHADICNLPALIP 474
            ..:.|||.|||.|||:|.|||.|||.:...|.: ..||..||||:||||:||.||||..:|.::.
Human   440 DLDDLAILYLATVQAIALGTRFIIEAMEAAGHS-ISTLFLCGGLSKNPLFVQMHADITGMPVVLS 503

  Fly   475 DEQEMVLVGAAALGAAASGHFDSLESASKSMGGTGQLVKPNAETLEFHNRKYKVFLQLLENQRQY 539
            .|.|.||||||.|||.|||.|.|::.|...|...|::|.|..:..:::::||:|||:|:|:|::|
Human   504 QEVESVLVGAAVLGACASGDFASVQEAMAKMSKVGKVVFPRLQDKKYYDKKYQVFLKLVEHQKEY 568

  Fly   540 RRIMQAD 546
            ..||..|
Human   569 LAIMNDD 575

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG11594	NP_001261391.1	FGGY_YpCarbK_like	5..540	CDD:212663	267/580 (46%)
CG11594	NP_001261391.1	5C_CHO_kinase	6..540	CDD:273552	267/574 (47%)
FGGY	NP_001106882.1	FGGY_YpCarbK_like	10..568	CDD:212663	267/574 (47%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165143501
Domainoid	1	1.000	283	1.000	Domainoid score	I1658
eggNOG	1	0.900	-	-		E1_COG0554
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H49535
Inparanoid	1	1.050	535	1.000	Inparanoid score	I1206
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG56396
OrthoDB	1	1.010	-	-		D1252682at2759
OrthoFinder	1	1.000	-	-		FOG0004956
OrthoInspector	1	1.000	-	-		oto91038
orthoMCL	1	0.900	-	-		OOG6_104010
Panther	1	1.100	-	-	LDO	PTHR43435
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2347
SonicParanoid	1	1.000	-	-		X4612
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	16	15.800