DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG11594 and fggy

DIOPT Version :9

Sequence 1:	NP_001261391.1	Gene:	CG11594 / 38473	FlyBaseID:	FBgn0035484	Length:	548	Species:	Drosophila melanogaster
Sequence 2:	NP_998446.2	Gene:	fggy / 406567	ZFINID:	ZDB-GENE-040426-2461	Length:	545	Species:	Danio rerio

Alignment Length:	557	Identity:	259/557 - (46%)
Similarity:	356/557 - (63%)	Gaps:	35/557 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 FFVGVDVGTGSARAALVACDGRVLEQAVQTIQTWNPEPGYYNQSSDNIWQSICQVVKKVIGGVDK 70
            ::||||||:.|.|||||:.||::...|.:.|....|...:|.|||..||...||.||:|..|||.
Zfish     5 YYVGVDVGSASVRAALVSPDGQLRRTAEEPIAVHEPCVDHYEQSSTEIWSKCCQTVKRVTEGVDA 69

  Fly    71 SKVKGIGFDATCSLVVLGPQGSPLTVSKSGEAEQNIILWMDHRAEQETQEINAFKHSLLKYVGGQ 135
            :.|:|||||.|||||||..|..||.|:.:|..::|:::||||||..:...|.|.:|:||:.|||.
Zfish    70 ACVRGIGFDGTCSLVVLDQQFRPLAVNLAGVCDRNVVMWMDHRAAAQASRITACRHTLLQRVGGV 134

  Fly   136 VSLEMEVPKLLWLKRNLSQTFGNIW----RVFDLPDFLTWRATGVDTRSLCSVVCKWNYDAANGS 196
            :|.|::.|||||||.||..   :.|    ..|||||||:|:|||..:||||::||||.|.|:.|
Zfish   135 MSPEIQPPKLLWLKENLPD---SCWTRAAHFFDLPDFLSWKATGSLSRSLCTLVCKWTYSASEG- 195

  Fly   197 WNKEFLKQADLEELTQNNFEKLGSDVQPPGRTVGKGLTAKAAGELGLSAGTVVSTSLIDAHAGAL 261
            |:..|.....||:|.::::.::||.|..||..||:||||.||.:|||:.||.|..||||||||.:
Zfish   196 WDDTFWSAIGLEDLIEDSYARIGSQVCCPGAAVGRGLTAAAAADLGLNEGTAVGASLIDAHAGGI 260

  Fly   262 GMFGCRSKESKGADDVQG------------KMALIAGTSTCHMSITRKACFAQGVWGPYQDAIIP 314
            |:.|.         ||.|            :||||.|||:|||:::|:.....||||||..|::|
Zfish   261 GVLGA---------DVSGLHLPCEHQPLTARMALICGTSSCHMAVSREPLLVPGVWGPYLSAMLP 316

  Fly   315 GYFLNEGGQSIAGHLLDHVLKSHESYAELKSQLGED-KFIYQHLNKLLPELAA-ARGLSQVGCLT 377
            |.:|||||||..|.|||||:|.|.::.:|:.|.... :.||..||..|.:::. |..|.|   ||
Zfish   317 GLWLNEGGQSATGKLLDHVVKGHAAFRQLEEQAEHSGRHIYTQLNLHLQQMSTDATHLEQ---LT 378

  Fly   378 QDVHVWPDLHGNRSPIADPTLRGVITGLDMTRGTESLAIKYLAFVQALAYGTRHIIENLYQYGRA 442
            ..:|:|||.||||||:||.|.||.:.||.:::..:.||:.|||.:||||.|:||||..:.:.|.
Zfish   379 THLHIWPDFHGNRSPLADQTARGTVVGLSLSQTLDDLALLYLATLQALALGSRHIIAAMTEAGH- 442

  Fly   443 PFQTLLFCGGLAKNPLYVQCHADICNLPALIPDEQEMVLVGAAALGAAASGHFDSLESASKSMGG 507
            ...||..||||:||.|:||.||:...||.::|.|:|.||:|||.:||.||....|:..|.:.|..
Zfish   443 DITTLFLCGGLSKNTLFVQTHANTTGLPVVLPAEREAVLLGAAVIGACASSDCTSIPEAMRKMSR 507

  Fly   508 TGQLVKPNAETLEFHNRKYKVFLQLLENQRQYRRIMQ 544
            .|::|:||.|...|:.|||.|||:|.::|::...:|:
Zfish   508 VGRVVRPNPELQSFYRRKYSVFLRLYQHQKECVSLME 544

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG11594	NP_001261391.1	FGGY_YpCarbK_like	5..540	CDD:212663	258/551 (47%)
CG11594	NP_001261391.1	5C_CHO_kinase	6..540	CDD:273552	258/551 (47%)
fggy	NP_998446.2	FGGY_YpCarbK_like	4..539	CDD:212663	258/550 (47%)
fggy	NP_998446.2	5C_CHO_kinase	5..538	CDD:273552	258/549 (47%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170576369
Domainoid	1	1.000	259	1.000	Domainoid score	I1955
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H49535
Inparanoid	1	1.050	493	1.000	Inparanoid score	I1366
OMA	1	1.010	-	-		QHG56396
OrthoDB	1	1.010	-	-		D1252682at2759
OrthoFinder	1	1.000	-	-		FOG0004956
OrthoInspector	1	1.000	-	-		oto39926
orthoMCL	1	0.900	-	-		OOG6_104010
Panther	1	1.100	-	-	LDO	PTHR43435
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2347
SonicParanoid	1	1.000	-	-		X4612
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	14	13.940