DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG11594 and CG8298

DIOPT Version :9

Sequence 1:	NP_001261391.1	Gene:	CG11594 / 38473	FlyBaseID:	FBgn0035484	Length:	548	Species:	Drosophila melanogaster
Sequence 2:	NP_610718.1	Gene:	CG8298 / 36282	FlyBaseID:	FBgn0033673	Length:	596	Species:	Drosophila melanogaster

Alignment Length:	522	Identity:	113/522 - (21%)
Similarity:	190/522 - (36%)	Gaps:	122/522 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly    42 EPGYYNQSSDNIWQSICQVVKK-----VIGGVDKSKVKGIGFDATCSLVVLGPQG-SPLTVSKSG 100
            :.|:.......||::..:.::.     ||..::...:..||        ::..:| |.|...::|
  Fly    49 QAGWMEYDPSEIWKNTQECIETAYKNLVILEINPRDIIAIG--------IVNQRGTSVLWNLETG 105

  Fly   101 EAEQNIILWMDHRAEQETQEINAFKHSL---LKYV----GGQVSLEMEVPKLLWLKRNLSQT--- 155
            :...|.|.|.|.|:   |..:....|::   :.||    |..:|......|:.||..::...
  Fly   106 QPLHNAIGWSDCRS---TPILKTLLHNVRHNVDYVRYRSGLPLSSCFSALKIRWLMDHVPAVATA 167

  Fly   156 -------FGNIWRVFDLPDFLTWRAT-GVDTRSLCSVVCKWNY----DAANGSWNKE----FLKQ 204
                   ||.      |..:|.|..| ||:.....:.:...:|    :.:...|:.:    |...
  Fly   168 IEENKCLFGT------LDSWLLWNLTGGVEMGVHSTDITNAHYTSLMNVSTEQWDPKLCQFFRLP 226

  Fly   205 ADLEELTQNNFEKLGSDVQPP--GRTVGKGL---TAKAAGELGLSAGTVVSTSLIDAHAGALGMF 264
            .::....::|.|..|..::.|  |..:...:   .|...|:|.:.||..|.| |.|:
  Fly   227 LNILPRIRSNSEIFGYVLEGPLHGTPIAAMMGEQPASLLGQLCVKAGQNVCT-LDDS-------- 282

  Fly   265 GCRSKESKGADDVQGKMALIAGTSTCHMSITRKACFAQGVWGPYQDAIIPGYFLNEGGQSIAGH- 328
             |....:.|.:.:.....||.|.:  | .:..||.              ..|.| ||..|.||.
  Fly   283 -CFVLLNTGREKLDSANGLITGIA--H-KLGEKAA--------------TNYTL-EGAISNAGST 328

  Fly   329 ---LLDHV-----LKSHESYAE-LKSQLGEDKFIYQHLNKLLPELAAARGLSQVGCLTQDVHVWP 384
               |.|.:     :.|:::..| |.:.:||:..|....:..:  |.|..||:   ....::...|
  Fly   329 VTWLRDKLQINTEINSNDNVVESLNTFIGENSMISSSCSSSM--LNAECGLA---AKRSEITFVP 388

  Fly   385 DLHGNRSPIADPTLRGVITGL-------DMTRGT-ESLAIKYLAFVQALAYGTRHIIENLYQYGR 441
            ..||..:|......||:|.||       ::|:.. |:...:....:||....|.:       :.|
  Fly   389 AFHGMYAPYWRHDARGIILGLTSQTTAENITQAAYEATGFQIFEVLQAFKRDTPN-------WDR 446

  Fly   442 APFQTLL-FCGGLAKNPLYVQCHADICNLPALIPDEQEMVLVGAAALG----AAASGHFDSLESA 501
            :..|.:| |.|..|:|...||..|||.......|.     ....|.||    |..:....|||.|
  Fly   447 SSMQPVLTFGGDYAENLHLVQFIADIIGYMLERPQ-----TTSPAGLGVMITAGVTMKVVSLEHA 506

  Fly   502 SK 503
            .|
  Fly   507 VK 508

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG11594	NP_001261391.1	FGGY_YpCarbK_like	5..540	CDD:212663	113/522 (22%)
CG11594	NP_001261391.1	5C_CHO_kinase	6..540	CDD:273552	113/522 (22%)
CG8298	NP_610718.1	FGGY_GK	12..534	CDD:198347	113/522 (22%)
CG8298	NP_610718.1	glycerol_kin	21..543	CDD:273549	113/522 (22%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45443087
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0554
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	3	2.740