DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG11594 and Fggy

DIOPT Version :9

Sequence 1:	NP_001261391.1	Gene:	CG11594 / 38473	FlyBaseID:	FBgn0035484	Length:	548	Species:	Drosophila melanogaster
Sequence 2:	XP_038965462.1	Gene:	Fggy / 298250	RGDID:	1359429	Length:	558	Species:	Rattus norvegicus

Alignment Length:	522	Identity:	255/522 - (48%)
Similarity:	352/522 - (67%)	Gaps:	39/522 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MSSGP-----FFVGVDVGTGSARAALVACDGRVLEQAVQTIQTWNPEPGYYNQSSDNIWQSICQV 60
            ||.|.     ::||:||||||.|||||...|.:|..|.|.|:.|.|:..::.|||::||.:.|:|
  Rat    32 MSGGDQEPDHYYVGIDVGTGSVRAALVDQRGVLLAFAEQPIKKWEPQFNHHEQSSEDIWAACCRV 96

  Fly    61 VKKVIGGVDKSKVKGIGFDATCSLVVLGPQGSPLTVSKSGEAEQNIILWMDHRAEQETQEINAFK 125
            .|:::.|:|..:::|:|||||||||||..:..||.|::.|::.:|||:|:||||..:...||..|
  Rat    97 TKEIVQGIDAHRIRGLGFDATCSLVVLDKEFHPLPVNREGDSSRNIIMWLDHRAVSQVHRINETK 161

  Fly   126 HSLLKYVGGQVSLEMEVPKLLWLKRNLSQTFGNIW----RVFDLPDFLTWRATGVDTRSLCSVVC 186
            ||:|:||||.:|:||:.|||||||.||.:.   .|    ..|||||||:|:||||..|||||:||
  Rat   162 HSVLQYVGGVMSVEMQAPKLLWLKENLREI---CWDKAGHFFDLPDFLSWKATGVTARSLCSLVC 223

  Fly   187 KWNYDAANGSWNKEFLKQADLEELTQNNFEKLGSDVQPPGRTVGKGLTAKAAGELGLSAGTVVST 251
            ||.|.|..| |:..|.|...||:|..:|:.|:|:.|.|||.::|.||..:||.||||.:|..|:.
  Rat   224 KWTYSAEKG-WDDSFWKMIGLEDLIGDNYNKIGNLVLPPGASLGSGLIPEAARELGLPSGIAVAA 287

  Fly   252 SLIDAHAGALGMFGCRSKESKGADDVQG------------KMALIAGTSTCHMSITRKACFAQGV 304
            ||||||||.||:.|.         ||:|            ::|:|.|||:|||.|::...|..||
  Rat   288 SLIDAHAGGLGVIGA---------DVRGHGLTCEGQPVTSRLAVICGTSSCHMGISKDPIFVPGV 343

  Fly   305 WGPYQDAIIPGYFLNEGGQSIAGHLLDHVLKSHESYAELKSQ-LGEDKFIYQHLNKLLPELAAAR 368
            ||||..|::||::|||||||:.|.|:||:::||.::.||::: ....:.||.:||..|..:..|:
  Rat   344 WGPYFSAMVPGFWLNEGGQSVTGKLIDHMVQSHPAFPELQAKATARCQSIYAYLNSHLDLIKKAQ 408

  Fly   369 GLSQVGCLTQDVHVWPDLHGNRSPIADPTLRGVITGLDMTRGTESLAIKYLAFVQALAYGTRHII 433
               .||.||.|:|||||.||||||:||.||:|::|||.::|..:.||:.|||.:||:|:|||.||
  Rat   409 ---PVGFLTVDLHVWPDFHGNRSPLADLTLKGMVTGLTLSRDLDDLAVLYLATIQAIAFGTRFII 470

  Fly   434 ENLYQYGRAPFQTLLFCGGLAKNPLYVQCHADICNLPALIPDEQEMVLVGAAALGAAASGHFDSL 498
            |.:...|.: ..||..||||:||||:||.||||..:|.::..|.|.||||||.|||.|||.|.|:
  Rat   471 ETMEAAGHS-LSTLFLCGGLSKNPLFVQMHADITGMPVVLSQEVESVLVGAAILGACASGDFASV 534

  Fly   499 ES 500
            ::
  Rat   535 QT 536

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG11594	NP_001261391.1	FGGY_YpCarbK_like	5..540	CDD:212663	252/518 (49%)
CG11594	NP_001261391.1	5C_CHO_kinase	6..540	CDD:273552	252/512 (49%)
Fggy	XP_038965462.1	FGGY_YpCarbK_like	41..536	CDD:212663	252/511 (49%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166337244
Domainoid	1	1.000	280	1.000	Domainoid score	I1608
eggNOG	1	0.900	-	-		E1_COG0554
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H49535
Inparanoid	1	1.050	534	1.000	Inparanoid score	I1160
OMA	1	1.010	-	-		QHG56396
OrthoDB	1	1.010	-	-		D1252682at2759
OrthoFinder	1	1.000	-	-		FOG0004956
OrthoInspector	1	1.000	-	-		oto98133
orthoMCL	1	0.900	-	-		OOG6_104010
Panther	1	1.100	-	-	LDO	PTHR43435
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X4612
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	16	15.770