DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG11594 and ATAD2

DIOPT Version :9

Sequence 1:	NP_001261391.1	Gene:	CG11594 / 38473	FlyBaseID:	FBgn0035484	Length:	548	Species:	Drosophila melanogaster
Sequence 2:	NP_054828.2	Gene:	ATAD2 / 29028	HGNCID:	30123	Length:	1390	Species:	Homo sapiens

Alignment Length:	580	Identity:	103/580 - (17%)
Similarity:	178/580 - (30%)	Gaps:	218/580 - (37%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 GPFFVGVDVGTGS---ARAALVAC---DGRV---LEQAVQTIQTW------------------NP 41
            |..|.| ..|||.   |||....|   |.||   :.:....:..|                  .|
Human   462 GCLFYG-PPGTGKTLVARALANECSQGDKRVAFFMRKGADCLSKWVGESERQLRLLFDQAYQMRP 525

  Fly    42 EPGYYNQ----------SSDNIWQSICQVVKKVIGGVD-KSKVKGIGFDATCSLVVLGPQGSPLT 95
            ...::::          ..|.|..||...:..::.|:| :.::..||  ||..|..:.|     .
Human   526 SIIFFDEIDGLAPVRSSRQDQIHSSIVSTLLALMDGLDSRGEIVVIG--ATNRLDSIDP-----A 583

  Fly    96 VSKSGEAEQNIILWM-DHRAEQETQEINAFKHSLLKYVGGQVSLEMEVPKLLWLKRNLSQTFGNI 159
            :.:.|..::..:..: |..|.:|..:|:.                                  ..
Human   584 LRRPGRFDREFLFSLPDKEARKEILKIHT----------------------------------RD 614

  Fly   160 WRVFDLPDFLTWRA------TGVDTRSLCSVVCKWNYDAANGSWNKEFLK--------QADLE-- 208
            |....|..||...|      .|.|.:|:|:       :||..:..:.:.:        |.||.
Human   615 WNPKPLDTFLEELAENCVGYCGADIKSICA-------EAALCALRRRYPQIYTTSEKLQLDLSSI 672

  Fly   209 ELTQNNFEKLGSDVQPPGRTVGKGLTAKAAGELGLSAGTVVSTSL---IDAHAGAL--------- 261
            .::..:||.....:.|..:        :|....|.:..|||...|   :|....||
Human   673 NISAKDFEVAMQKMIPASQ--------RAVTSPGQALSTVVKPLLQNTVDKILEALQRVFPHAEF 729

  Fly   262 -------GMFGCRSKESKGA---DDVQG--------KMALIAGTSTCHMSITRKACFAQGVWGPY 308
                   ....|...||..|   |||..        |.:..|..:...:.:.|.||:....:.|
Human   730 RTNKTLDSDISCPLLESDLAYSDDDVPSVYENGLSQKSSHKAKDNFNFLHLNRNACYQPMSFRP- 793

  Fly   309 QDAIIPGYFLNEGGQSIAGHLLDHVLKSHESYA----ELKSQLGEDKFIYQHLNKLLPELAAARG 369
             ..:|.|    |.|.....||...|:.:.|.:.    ::....|        ::...||...|:.
Human   794 -RILIVG----EPGFGQGSHLAPAVIHALEKFTVYTLDIPVLFG--------VSTTSPEETCAQV 845

  Fly   370 LSQVG------CLTQDVHVWPDLHGNRSPIADPTLRGVITGLDMTRGTESLAIKYLAFVQALAYG 428
            :.:..      .....:|||.::.|       |||:...|.|
Human   846 IREAKRTAPSIVYVPHIHVWWEIVG-------PTLKATFTTL----------------------- 880

  Fly   429 TRHIIENLYQYGRAPFQTLLFCGGLAKNP----------LYVQCHADICNLPALIPDEQE 478
                ::|:..:  ||...|    ..:..|          |:::.:.:|.|:.  :||::|
Human   881 ----LQNIPSF--APVLLL----ATSDKPHSALPEEVQELFIRDYGEIFNVQ--LPDKEE 928

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG11594	NP_001261391.1	FGGY_YpCarbK_like	5..540	CDD:212663	102/579 (18%)
CG11594	NP_001261391.1	5C_CHO_kinase	6..540	CDD:273552	102/578 (18%)
ATAD2	NP_054828.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	40..63
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	216..380
		AAA	459..600	CDD:214640	28/145 (19%)
		AAA	464..598	CDD:278434	27/141 (19%)
		COG5076	<915..1153	CDD:227408	5/16 (31%)
		Bromo_AAA	987..1097	CDD:99957
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1124..1163
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1181..1242
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0554
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900