DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment FoxL1 and FOXH1

DIOPT Version :9

Sequence 1:	NP_001246609.1	Gene:	FoxL1 / 38471	FlyBaseID:	FBgn0004895	Length:	365	Species:	Drosophila melanogaster
Sequence 2:	NP_003914.1	Gene:	FOXH1 / 8928	HGNCID:	3814	Length:	365	Species:	Homo sapiens

Alignment Length:	235	Identity:	69/235 - (29%)
Similarity:	106/235 - (45%)	Gaps:	56/235 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly    88 RPEKPPFSYIALIAMAISSAPNQRLTLSGIYKFIMDKFPYYRENKQGWQNSIRHNLSLNDCFVKI 152
            |.:|||::|:|:||:.|.:||::||.|:.|.:.:...||::||:.:||::|||||||.|.||.|:
Human    30 RHDKPPYTYLAMIALVIQAAPSRRLKLAQIIRQVQAVFPFFREDYEGWKDSIRHNLSSNRCFRKV 94

  Fly   153 PRDKNTIEDNDSAGKGSYWMLDSSASDMFEQGNYRRRRT---RRQRHCGHPNRYERESGKDSNDG 214
            |:|....:     .||::|.:|.|   :......|.:.|   ||.::.|....:.::.|.....|
Human    95 PKDPAKPQ-----AKGNFWAVDVS---LIPAEALRLQNTALCRRWQNGGARGAFAKDLGPYVLHG 151

  Fly   215 NSSAAEIRSPSEPLSDFDIFCNERPNYSDRITDLHRQYLSVSLGFN--SLFNNEARGLRPLPEIR 277
            .    ..|.||.|           |..|:              ||:  ||......| .|.|.:.
Human   152 R----PYRPPSPP-----------PPPSE--------------GFSIKSLLGGSGEG-APWPGLA 186

  Fly   278 ECPDDVDASSSSSKAMQSSMELHEELHSPSAFTPPLNRRE 317
            .....|.|.:.:|         .||    :..||||...|
Human   187 PQSSPVPAGTGNS---------GEE----AVPTPPLPSSE 213

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
FoxL1	NP_001246609.1	FH	91..185	CDD:214627	38/93 (41%)
FOXH1	NP_003914.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..29
		FH	33..111	CDD:238016	36/82 (44%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	151..215		24/106 (23%)
		SMAD-interaction domain (SID)	273..354
		Fast/FoxH1 motif 1 (FM1)	277..281
		Fast/FoxH1 motif 2 (FM2)	287..293
		SMAD interaction motif (SIM)	327..348
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG2294
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1270467at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.820