DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment FoxL1 and foxk2b

DIOPT Version :9

Sequence 1:	NP_001246609.1	Gene:	FoxL1 / 38471	FlyBaseID:	FBgn0004895	Length:	365	Species:	Drosophila melanogaster
Sequence 2:	XP_001922856.1	Gene:	foxk2b / 798356	ZFINID:	ZDB-GENE-030131-5310	Length:	597	Species:	Danio rerio

Alignment Length:	366	Identity:	100/366 - (27%)
Similarity:	154/366 - (42%)	Gaps:	89/366 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly    12 LPDNEELVNSMLANPDYLRTQVSPNPLAPSAVGGAGMEGLMCGSFSPAFYYQGIDSFLALHNNIW 76
            :|||...:.|.|.:|   ...:|.....||:..|||..|...|...|
Zfish   140 IPDNIAHLMSPLPSP---TGTISAANSCPSSPRGAGSSGYRLGRIVP------------------ 183

  Fly    77 GLPISFLHNSHRPE---------------KPPFSYIALIAMAISSAPNQRLTLSGIYKFIMDKFP 126
              .:..::::.:.|               |||:||..||..||:.||:::|||:|||..|...:|
Zfish   184 --DLQLMNDNSQSENDKETSEGDSPKDDSKPPYSYAQLIVQAITMAPDKQLTLNGIYTHITKNYP 246

  Fly   127 YYRENKQGWQNSIRHNLSLNDCFVKIPRDKNTIEDNDSAGKGSYWMLDSSASDMFEQGNYRRRRT 191
            |||...:|||||||||||||..|:|:||.:      :..||||:|.:|.|:.....:..:|:||.
Zfish   247 YYRTADKGWQNSIRHNLSLNRYFIKVPRSQ------EEPGKGSFWRIDPSSEGKLVEQAFRKRRP 305

  Fly   192 RRQRHCGHPNRYERESGKDSNDGNSSAAEIRSPSEPLSDFDIFCNERPNYSDRITDLHRQYLSVS 256
            |     |.|.                   .|:|..|||...  ....||:|. :...|...:...
Zfish   306 R-----GVPC-------------------FRTPLGPLSSRS--APASPNHSG-VLSAHSSGVQTP 343

  Fly   257 LGFNSLFNNEARGLRPLPEIRECPDDVDASSSSSKAMQSSMELHEELHSPSAFTPPLNRRETSSS 321
               :||    :|...|:|...|.......::.:..|:|..:.:.:|    :.||.  |...:..:
Zfish   344 ---DSL----SREGSPVPMESEPVSVPPPAAVAVAAVQPKLAVIQE----TRFTQ--NTTASPIT 395

  Fly   322 GAPVLAEA----FNGIKDVVDAPGSSPVASSNRSKTTLFTI 358
            ..|||...    ...:|.|..|. ::||:||..::..:.|:
Zfish   396 TQPVLIAVQRPLTQNMKPVTYAV-AAPVSSSTSAQPLMQTV 435

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
FoxL1	NP_001246609.1	FH	91..185	CDD:214627	46/93 (49%)
foxk2b	XP_001922856.1	FHA	17..109	CDD:238017
foxk2b	XP_001922856.1	Forkhead	211..297	CDD:278670	46/91 (51%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG2294
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1270467at2759
OrthoFinder	1	1.000	-	-		FOG0000010
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2114
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	5	4.850