DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment FoxL1 and Foxm1

DIOPT Version :9

Sequence 1:	NP_001246609.1	Gene:	FoxL1 / 38471	FlyBaseID:	FBgn0004895	Length:	365	Species:	Drosophila melanogaster
Sequence 2:	NP_113821.2	Gene:	Foxm1 / 58921	RGDID:	61807	Length:	771	Species:	Rattus norvegicus

Alignment Length:	309	Identity:	82/309 - (26%)
Similarity:	123/309 - (39%)	Gaps:	66/309 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly    90 EKPPFSYIALIAMAISSAPNQRLTLSGIYKFIMDKFPYYRE-NKQGW------------QNSIRH 141
            |:||:||:|:|..||:|...:|:||..||.:|.|.|||::. .|.||            ||||||
  Rat   234 ERPPYSYMAMIQFAINSTERKRMTLKDIYTWIEDHFPYFKHIAKPGWKCWHQAYHKLGPQNSIRH 298

  Fly   142 NLSLNDCFVKIPRDKNTIEDNDSAGKGSYWMLDSSAS------DMF---EQGNYR---RRRTRRQ 194
            ||||:|.||:         :..:.||.|:|.:..||:      .:|   |.|:.:   ...::::
  Rat   299 NLSLHDMFVR---------ETSANGKVSFWTIHPSANRYLTLDQVFKPLEPGSPQSPEHLESQQK 354

  Fly   195 RHCGHPNRYERESGKDSNDGNSSAAEIRSPSEP-----LSDFDIFCNE----RPNY--------S 242
            |    ||...|.:.....:....|.....|..|     |.......|:    :|:.        |
  Rat   355 R----PNPELRRNVTIKTELPLGARRKMKPLLPRVSSYLVPIQFPVNQSLVLQPSVKVPLPLAAS 415

  Fly   243 DRITDLHRQYLSVSLGFNSLFNNEARGLRPLPEIRECPDDVDASSSSSKAMQSSMELHEELHSPS 307
            ...::|.|....|.:....|.:||  |:.|||......::..........:.....:.||:..|.
  Rat   416 LMSSELARHSKRVRIAPKVLLSNE--GIAPLPATEPMKEEKPLLGEGLLPLLPIQSIKEEVIQPG 478

  Fly   308 AFTPPLNR---------RETSSSGAPVLAEAFNGIKDVVDAPGSSPVAS 347
            ...|.|.|         .|..|..|.|..|..|..:|...:|...|..|
  Rat   479 EDIPHLERPIKVESPPLEEWPSPCASVKEELSNSWEDSSCSPTPKPKKS 527

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
FoxL1	NP_001246609.1	FH	91..185	CDD:214627	43/115 (37%)
Foxm1	NP_113821.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..54
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	94..165
		FH	235..322	CDD:238016	39/95 (41%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	340..361		4/24 (17%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	542..568
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	584..655
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	693..718
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG2294
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1270467at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.820