DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment FoxL1 and foxa2

DIOPT Version :9

Sequence 1:	NP_001246609.1	Gene:	FoxL1 / 38471	FlyBaseID:	FBgn0004895	Length:	365	Species:	Drosophila melanogaster
Sequence 2:	NP_989423.1	Gene:	foxa2 / 395063	XenbaseID:	XB-GENE-480476	Length:	434	Species:	Xenopus tropicalis

Alignment Length:	346	Identity:	111/346 - (32%)
Similarity:	158/346 - (45%)	Gaps:	72/346 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 PSCY-------ANGSMLPDNEELVNSMLA----------NPDYLRTQVSPNPLAPSAVGGAGMEG 50
            |..|       |..||.|.|..:..|.::          |..|:.|.:||: |...:.|...|.|
Frog    22 PEAYSSVGNMNAGLSMNPMNTYMSMSAMSTSANMTAGSMNMSYVNTGMSPS-LTGMSPGTGAMTG 85

  Fly    51 LMCG----------SFSPAFYYQGIDSFLALHNNIWGL-PI---SFLHNSHRPE---------KP 92
            :..|          |.||........:.||.:.|:..: ||   |.::.|..|:         ||
Frog    86 MGTGVASMASHLSPSMSPMSAQATSMNALAPYTNMNSMSPIYGQSNINRSRDPKTYRRSYTHAKP 150

  Fly    93 PFSYIALIAMAISSAPNQRLTLSGIYKFIMDKFPYYRENKQGWQNSIRHNLSLNDCFVKIPRDKN 157
            |:|||:||.|||..:||:.||||.||::|||.||:||:|:|.|||||||:||.||||:|:||..
Frog   151 PYSYISLITMAIQQSPNKMLTLSEIYQWIMDLFPFYRQNQQRWQNSIRHSLSFNDCFLKVPRSP- 214

  Fly   158 TIEDNDSAGKGSYWMLDSSASDMFEQGNYRRRRTRRQRHCGHPNRYERESGKDSNDGNSSAAEIR 222
                 |..||||:|.|...:.:|||.|.|.||:.|.:  |..........||..::|:||.....
Frog   215 -----DKPGKGSFWTLHPDSGNMFENGCYLRRQKRFK--CEKKPSLREGGGKKLSEGSSSVGSAA 272

  Fly   223 SPSEPLSDFDIFCNERPNYSDRITDLHRQYLSVSLGFNSLFNNEARGLRPLPEIRECPDDVDASS 287
            :.|...|    ..||.|:.|.......::.| |.:       ..::||.|           |.::
Frog   273 NSSSESS----VGNESPHSSSSPCQEQKRSL-VDM-------KSSQGLSP-----------DHAA 314

  Fly   288 SSSKAMQSSMELHEELHSPSA 308
            |.:...|..:..|..:.|..|
Frog   315 SPASQAQHLLSQHHSVLSHEA 335

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
FoxL1	NP_001246609.1	FH	91..185	CDD:214627	54/93 (58%)
foxa2	NP_989423.1	Forkhead_N	17..148	CDD:369872	29/126 (23%)
		FH	149..237	CDD:214627	54/93 (58%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	249..339		22/110 (20%)
		HNF_C	349..423	CDD:370449
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000010
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.910