DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment FoxL1 and foxa4

DIOPT Version :9

Sequence 1:	NP_001246609.1	Gene:	FoxL1 / 38471	FlyBaseID:	FBgn0004895	Length:	365	Species:	Drosophila melanogaster
Sequence 2:	NP_988938.1	Gene:	foxa4 / 394535	XenbaseID:	XB-GENE-486455	Length:	399	Species:	Xenopus tropicalis

Alignment Length:	247	Identity:	93/247 - (37%)
Similarity:	125/247 - (50%)	Gaps:	50/247 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly    19 VNSMLANPDYLRTQVSPNPLA------------PSAVGGAGMEGL----MCGSF-----SPAF-- 60
            :|:.|.:..:|.|.||..|.:            .|..|..|..|.    |.||.     :||:
Frog    31 MNNGLPSNSFLPTDVSTVPTSMPYMSNGLSGPVTSIQGNLGSLGSMTQGMVGSLAPPASTPAYPM 95

  Fly    61 -YYQGIDSFLALHNNIWGLPISFLHN-SHRPEKPPFSYIALIAMAISSAPNQRLTLSGIYKFIMD 123
             |.||...|..       .|.::..| ||  .|||:|||:||.|||..|||:.:||:.||::|:|
Frog    96 GYCQGESEFQR-------DPRTYRRNYSH--AKPPYSYISLITMAIQQAPNKMMTLNEIYQWIID 151

  Fly   124 KFPYYRENKQGWQNSIRHNLSLNDCFVKIPRDKNTIEDNDSAGKGSYWMLDSSASDMFEQGNYRR 188
            .|||||:|:|.|||||||:||.||||||:||..      :..||||||.|...:.:|||.|.|.|
Frog   152 LFPYYRQNQQRWQNSIRHSLSFNDCFVKVPRSP------EKPGKGSYWTLHPESGNMFENGCYLR 210

  Fly   189 RRTR----------RQRHCGHPNRYERESGKDSNDGNSSAAEIRSPSEPLSD 230
            |:.|          |::....|......|.|::..|....:..|||..|::|
Frog   211 RQKRFKCERSKSGEREKKVNKPGDENGGSLKETPVGYDDCSSSRSPQAPVND 262

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
FoxL1	NP_001246609.1	FH	91..185	CDD:214627	54/93 (58%)
foxa4	NP_988938.1	Forkhead_N	<25..118	CDD:369872	24/95 (25%)
		COG5025	<118..303	CDD:227358	69/151 (46%)
		FH	119..207	CDD:214627	54/93 (58%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	219..290		10/44 (23%)
		HNF_C	326..387	CDD:370449
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000010
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.910