DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment FoxL1 and foxk2a

DIOPT Version :9

Sequence 1:	NP_001246609.1	Gene:	FoxL1 / 38471	FlyBaseID:	FBgn0004895	Length:	365	Species:	Drosophila melanogaster
Sequence 2:	NP_001184186.1	Gene:	foxk2a / 324141	ZFINID:	ZDB-GENE-030131-2861	Length:	544	Species:	Danio rerio

Alignment Length:	355	Identity:	96/355 - (27%)
Similarity:	143/355 - (40%)	Gaps:	108/355 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly    12 LPDNEELVNSMLANPDYLRTQVSPNPLAPSAVGGAGMEGLMCGSFSPAFYYQGIDSFLALHNNIW 76
            :|:|...:.|.|.:|   ...:|.....||:..|||:.....|.
Zfish   134 IPENITHLRSPLPSP---TGTISAANSCPSSPRGAGLSSYRMGR--------------------- 174

  Fly    77 GLPISFLHNSHRPE---------------KPPFSYIALIAMAISSAPNQRLTLSGIYKFIMDKFP 126
            ||....::.:.:.|               |||:||..||..||:.||:::|||:|||..|...:|
Zfish   175 GLTAELINENSQSEIDKEASGGDSPKDDSKPPYSYAQLIVQAITMAPDKQLTLNGIYTHITKNYP 239

  Fly   127 YYRENKQGWQNSIRHNLSLNDCFVKIPRDKNTIEDNDSAGKGSYWMLDSSASDMFEQGNYRRRRT 191
            |||...:|||||||||||||..|:|:.|.:      :..||||:|.:|.|:........:|:||.
Zfish   240 YYRTADKGWQNSIRHNLSLNRYFIKVARSQ------EEPGKGSFWRIDPSSEGKLMDQAFRKRRP 298

  Fly   192 RRQRHCGHPNRYERESGKDSNDGNSSAAEIRSPSEPLSDFDIFCNERPNYSDRITDLHRQYLSV- 255
            |     |.|.                   .|:|..|||          :.|...:..|...||.
Zfish   299 R-----GVPC-------------------FRTPLGPLS----------SRSAPASPTHTGVLSAH 329

  Fly   256 SLGFNSLFNNEARGLRPLPEIRECPDDVDASSSSSKAMQSSMELHEELHSPSAFTPPLNRRETSS 320
            |.|..:  .:.:|...|||        ::...|::.|.|..:.:.:|    |.||       .::
Zfish   330 SSGVQT--PDSSREGSPLP--------LEPEPSAAAAPQPKLAVIQE----SCFT-------QNT 373

  Fly   321 SGAPV-------LAEAFNGIKDVVDAPGSS 343
            .|:||       |.::...:...|..|.||
Zfish   374 PGSPVLIAVQQPLQQSLKPVSFSVATPASS 403

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
FoxL1	NP_001246609.1	FH	91..185	CDD:214627	45/93 (48%)
foxk2a	NP_001184186.1	FHA	16..105	CDD:238017
foxk2a	NP_001184186.1	Forkhead	204..290	CDD:278670	45/91 (49%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG2294
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1270467at2759
OrthoFinder	1	1.000	-	-		FOG0000010
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2114
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	5	4.850