Protein Alignment FoxL1 and FOXA2

DIOPT Version :10

• Sequence 1: NP_523912.1
• Gene: FoxL1 / 38471
• FlyBaseID: FBgn0004895
• Length: 365
• Species: Drosophila melanogaster
• Sequence 2: NP_068556.2
• Gene: FOXA2 / 3170
• HGNCID: 5022
• Length: 463
• Species: Homo sapiens
• Alignment Length: 369
• Identity: 112/369 - (30%)
• Similarity: 158/369 - (42%)
• Gaps: 101/369 - (27%)

  Fly     4 SCYANGSMLPDNEELVNSMLANPDYLRTQVSPNPLAPSAVGG----AGMEGL------------- 51
            |.|....|.|.        ||.       :||...|.:.:||    ||:.|:
Human    72 SSYVGAGMSPS--------LAG-------MSPGAGAMAGMGGSAGAAGVAGMGPHLSPSLSPLGG 121

  Fly    52 ----MCGSFSPAFYYQGIDSFLALHNNIWGL-----PISFLHNSHRPEKPPFSYIALIAMAISSA 107
                ..|..:|   |..::|...::... ||     |.:: ..|:...|||:|||:||.|||..:
Human   122 QAAGAMGGLAP---YANMNSMSPMYGQA-GLSRARDPKTY-RRSYTHAKPPYSYISLITMAIQQS 181

  Fly   108 PNQRLTLSGIYKFIMDKFPYYRENKQGWQNSIRHNLSLNDCFVKIPRDKNTIEDNDSAGKGSYWM 172
            ||:.||||.||::|||.||:||:|:|.|||||||:||.||||:|:||..      |..||||:|.
Human   182 PNKMLTLSEIYQWIMDLFPFYRQNQQRWQNSIRHSLSFNDCFLKVPRSP------DKPGKGSFWT 240

  Fly   173 LDSSASDMFEQGNYRRRRTRRQRHCGHPNRYERE-----------SGKDSNDG-NSSAAEIRSPS 225
            |...:.:|||.|.|.||:.|.:  |      |::           |||.:..| .:|.|::...:
Human   241 LHPDSGNMFENGCYLRRQKRFK--C------EKQLALKEAAGAAGSGKKAAAGAQASQAQLGEAA 297

  Fly   226 EPLSDFDIFCNERPNYSDRITDLHRQYLSVSLGFNSLFNNEARGLRPLPEIRECPDDVDASSSSS 290
            .|.|:... ..|.|:.|......|::.     |...|....|..|.| ||         .:.|..
Human   298 GPASETPA-GTESPHSSASPCQEHKRG-----GLGELKGTPAAALSP-PE---------PAPSPG 346

  Fly   291 KAMQSSMELHEELHSPS-------------AFTPPLNRRETSSS 321
            :..|::..|....|.|.             ||..|.:.....||
Human   347 QQQQAAAHLLGPPHHPGLPPEAHLKPEHHYAFNHPFSINNLMSS 390

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
FoxL1	NP_523912.1	FH_FOX	89..186	CDD:469596	55/96 (57%)
FOXA2	NP_068556.2	Forkhead_N	23..164	CDD:369872	22/111 (20%)
		FH_FOXA2	163..264	CDD:410813	60/114 (53%)
		HNF_C	379..452	CDD:430552	3/12 (25%)