Protein Alignment FoxL1 and FOXO1

DIOPT Version :10

• Sequence 1: NP_523912.1
• Gene: FoxL1 / 38471
• FlyBaseID: FBgn0004895
• Length: 365
• Species: Drosophila melanogaster
• Sequence 2: NP_002006.2
• Gene: FOXO1 / 2308
• HGNCID: 3819
• Length: 655
• Species: Homo sapiens
• Alignment Length: 453
• Identity: 99/453 - (21%)
• Similarity: 158/453 - (34%)
• Gaps: 163/453 - (35%)

  Fly     2 LPSCYA---------NGSMLPDNEELVNSMLANPDYLRTQVSPNPLAP-------SAVGGAGMEG 50
            |||..|         |.|:|.::|:.                  |.||       :|...|...|
Human    58 LPSASAAAVSADFMSNLSLLEESEDF------------------PQAPGSVAAAVAAAAAAAATG 104

  Fly    51 LMCGSFSPAFYYQGIDSFLALHNNIWGLPISFLHN-----------SHRPEKPP----------- 93
            .:||.|      ||.::             ..||.           |..|..||
Human   105 GLCGDF------QGPEA-------------GCLHPAPPQPPPPGPLSQHPPVPPAAAGPLAGQPR 150

  Fly    94 ------------FSYIALIAMAISSAPNQRLTLSGIYKFIMDKFPYYRE-----NKQGWQNSIRH 141
                        .||..||..||.|:..:|||||.||::::...||:::     :..||:|||||
Human   151 KSSSSRRNAWGNLSYADLITKAIESSAEKRLTLSQIYEWMVKSVPYFKDKGDSNSSAGWKNSIRH 215

  Fly   142 NLSLNDCFVKIPRDKNTIEDNDSAGKGSYWMLDSS-----------ASDMFEQGNYRRRRTRRQR 195
            ||||:..|:::        .|:..||.|:|||:..           |:.|.....:.:.|:|..:
Human   216 NLSLHSKFIRV--------QNEGTGKSSWWMLNPEGGKSGKSPRRRAASMDNNSKFAKSRSRAAK 272

  Fly   196 HCGHPNRYERESGKDSNDGNSSAAEIRSPSEPLS----DFDIFCNERPNYSDRITDLHRQYLSV- 255
                 .:...:||::....:..:...:.|:.|.|    |||.:...||..|...:.:..:...:
Human   273 -----KKASLQSGQEGAGDSPGSQFSKWPASPGSHSNDDFDNWSTFRPRTSSNASTISGRLSPIM 332

  Fly   256 ----SLGFNSLFN-----NEARGLRPLPEIREC--PDD------------------VDASSSSSK 291
                .||...:.:     :.|:....||.:.|.  |::                  |...||...
Human   333 TEQDDLGEGDVHSMVYPPSAAKMASTLPSLSEISNPENMENLLDNLNLLSSPTSLTVSTQSSPGT 397

  Fly   292 AMQ-----SSMELHEELHSPSAFTPPLNRRETSSSGAPVL--------AEAFNGIKDVVDAPG 341
            .||     |....:..|:|||.........::|.|..|.:        ..::.|:.....|||
Human   398 MMQQTPCYSFAPPNTSLNSPSPNYQKYTYGQSSMSPLPQMPIQTLQDNKSSYGGMSQYNCAPG 460

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
FoxL1	NP_523912.1	FH_FOX	89..186	CDD:469596	40/135 (30%)
FOXO1	NP_002006.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..63		3/4 (75%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	116..158		6/41 (15%)
		FH_FOXO1	151..249	CDD:410834	35/105 (33%)
		DNA-binding. /evidence=ECO:0000269|PubMed:18786403	211..218		6/6 (100%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	234..344		21/114 (18%)
		DNA-binding. /evidence=ECO:0000269|PubMed:18786403	234..237		1/2 (50%)
		Nuclear localization signal	251..253		0/1 (0%)
		Sufficient for interaction with NLK. /evidence=ECO:0000250|UniProtKB:Q9R1E0	283..563		33/178 (19%)
		Required for interaction with RUNX2. /evidence=ECO:0000250|UniProtKB:Q9R1E0	363..459		16/95 (17%)
		FOXO_KIX_bdg	423..504	CDD:465228	7/38 (18%)
		Required for interaction with SIRT1. /evidence=ECO:0000250|UniProtKB:Q9R1E0	462..466
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	507..537
		FOXO-TAD	597..633	CDD:435506