DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment FoxL1 and FOXI1

DIOPT Version :9

Sequence 1:	NP_001246609.1	Gene:	FoxL1 / 38471	FlyBaseID:	FBgn0004895	Length:	365	Species:	Drosophila melanogaster
Sequence 2:	NP_036320.2	Gene:	FOXI1 / 2299	HGNCID:	3815	Length:	378	Species:	Homo sapiens

Alignment Length:	369	Identity:	114/369 - (30%)
Similarity:	152/369 - (41%)	Gaps:	114/369 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly    27 DYLRTQVSPNPLAPSAVGGAG---------------------MEGLMCGSFSPAFYYQGID---- 66
            ::...|..|:|..||..||..                     :.|.....|.|..|  |:.
Human    34 NFFHPQGVPSPQRPSFEGGGEYGATPNPYLWFNGPTMTPPPYLPGPNASPFLPQAY--GVQRPLL 96

  Fly    67 -SFLALHNNIWG-LPISFLHNSHRPEKPPFSYIALIAMAISSAPNQRLTLSGIYKFIMDKFPYYR 129
             |...|..:..| |||.......:..:||:||.|||||||..||::|||||.||:::.|.||:|.
Human    97 PSVSGLGGSDLGWLPIPSQEELMKLVRPPYSYSALIAMAIHGAPDKRLTLSQIYQYVADNFPFYN 161

  Fly   130 ENKQGWQNSIRHNLSLNDCFVKIPRDKNTIEDNDSAGKGSYWMLDSSASDMFEQGNYRRRRTRRQ 194
            ::|.||||||||||||||||.|:|||:      |..|||:||.||.:...||:.||:||:|.|:
Human   162 KSKAGWQNSIRHNLSLNDCFKKVPRDE------DDPGKGNYWTLDPNCEKMFDNGNFRRKRKRK- 219

  Fly   195 RHCGHPNRYERESGKDSNDGNSSAAE-----------IRSP--SEPLSDFDIFCNERPNYSDRIT 246
                             :|.:||.|.           :.||  :||.   ||.....|.
Human   220 -----------------SDVSSSTASLALEKTESSLPVDSPKTTEPQ---DILDGASPG------ 258

  Fly   247 DLHRQYLSVSLGFNSLFNNEARGLRPLPEIRECPDDVDASSSSSKAMQSSMELHEELHSPSA--- 308
                                  |....||.|..|....|...:|  ..|||..:....||::
Human   259 ----------------------GTTSSPEKRPSPPPSGAPCLNS--FLSSMTAYVSGGSPTSHPL 299

  Fly   309 FTPPLNRRETSSSGAPVLAEAFNGIKDVVDAPGSSPVAS-SNRS 351
            .||.|:...:..:|...|  .||..         ||:.: ||.|
Human   300 VTPGLSPEPSDKTGQNSL--TFNSF---------SPLTNLSNHS 332

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
FoxL1	NP_001246609.1	FH	91..185	CDD:214627	55/93 (59%)
FOXI1	NP_036320.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..26
		FH	123..211	CDD:214627	55/93 (59%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	208..278		23/118 (19%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG2294
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1270467at2759
OrthoFinder	1	1.000	-	-		FOG0000010
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11829
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	5	4.920