DRSC/TRiP Functional Genomics Resources

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Protein Alignment FoxL1 and FOXC1

DIOPT Version :9

Sequence 1:NP_001246609.1 Gene:FoxL1 / 38471 FlyBaseID:FBgn0004895 Length:365 Species:Drosophila melanogaster
Sequence 2:NP_001444.2 Gene:FOXC1 / 2296 HGNCID:3800 Length:553 Species:Homo sapiens


Alignment Length:390 Identity:125/390 - (32%)
Similarity:173/390 - (44%) Gaps:123/390 - (31%)


- Green bases have known domain annotations that are detailed below.


  Fly    20 NSMLANPDYLRTQVSPNPLAPSAVGG--AGMEGLMCGSFSPAF--YYQGIDSFLALHNNIWGLPI 80
            ||:...| ||..:.|....|.:|.||  ..|...|.....||.  .|.|            |:..
Human    11 NSLGVVP-YLGGEQSYYRAAAAAAGGGYTAMPAPMSVYSHPAHAEQYPG------------GMAR 62

  Fly    81 SFLHNSHRPE-----KPPFSYIALIAMAISSAPNQRLTLSGIYKFIMDKFPYYRENKQGWQNSIR 140
            ::...:.:|:     |||:||||||.|||.:||::::||:|||:||||:||:||:||||||||||
Human    63 AYGPYTPQPQPKDMVKPPYSYIALITMAIQNAPDKKITLNGIYQFIMDRFPFYRDNKQGWQNSIR 127

  Fly   141 HNLSLNDCFVKIPRDKNTIEDNDSAGKGSYWMLDSSASDMFEQGNYRRRRTRRQR---------- 195
            ||||||:||||:||      |:...||||||.||..:.:|||.|::.|||.|.::          
Human   128 HNLSLNECFVKVPR------DDKKPGKGSYWTLDPDSYNMFENGSFLRRRRRFKKKDAVKDKEEK 186

  Fly   196 ---HCGH---PNRYERESGKDSNDGNSSAAE---IR------------SPSEPLSDFDIFCNERP 239
               |...   |.|....:..:..|||:...:   :|            ||.:|||.         
Human   187 DRLHLKEPPPPGRQPPPAPPEQADGNAPGPQPPPVRIQDIKTENGTCPSPPQPLSP--------- 242

  Fly   240 NYSDRITDLHRQYLSVSLGFNSLFNNEARGLRPLPEIRECPDDVDASSSSSKAMQSSMELHEELH 304
                          :.:||..|        ...:|:| |.||...:|.||..:...|:       
Human   243 --------------AAALGSGS--------AAAVPKI-ESPDSSSSSLSSGSSPPGSL------- 277

  Fly   305 SPSAFTPPLNRRETSSSGAPVLAEAFNGIKDVVDAPGSSPVASSNRSKTTLFTIDNII----GKP 365
             |||  .||:.....|:..|             .||.:.|...|..     |::|||:    |.|
Human   278 -PSA--RPLSLDGADSAPPP-------------PAPSAPPPHHSQG-----FSVDNIMTSLRGSP 321

  Fly   366  365
            Human   322  321

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
FoxL1NP_001246609.1 FH 91..185 CDD:214627 61/93 (66%)
FOXC1NP_001444.2 Required for transcriptional activation. /evidence=ECO:0000269|PubMed:11782474 1..51 12/40 (30%)
FH 78..166 CDD:214627 61/93 (66%)
Nuclear localization signal 1 (NLS 1). /evidence=ECO:0000269|PubMed:11782474 78..93 12/14 (86%)
Nuclear localization signal 2 (NLS 2). /evidence=ECO:0000269|PubMed:11782474 168..176 4/7 (57%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 173..310 37/196 (19%)
Required for transcriptional inhibition. /evidence=ECO:0000269|PubMed:11782474 215..366 35/167 (21%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 356..387
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 414..465
Required for transcriptional activation. /evidence=ECO:0000269|PubMed:11782474 466..553
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D1270467at2759
OrthoFinder 1 1.000 - - FOG0000010
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 1 1.100 - - O PTHR11829
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
44.020

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