DRSC/TRiP Functional Genomics Resources

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Protein Alignment FoxL1 and FOXK1

DIOPT Version :9

Sequence 1:NP_001246609.1 Gene:FoxL1 / 38471 FlyBaseID:FBgn0004895 Length:365 Species:Drosophila melanogaster
Sequence 2:NP_001032242.1 Gene:FOXK1 / 221937 HGNCID:23480 Length:733 Species:Homo sapiens


Alignment Length:345 Identity:104/345 - (30%)
Similarity:141/345 - (40%) Gaps:98/345 - (28%)


- Green bases have known domain annotations that are detailed below.


  Fly    23 LANPDYLRTQVSPNP----------LAPSAVGGAGMEGLMCGSFSPAFYYQGIDSFLALHNNIWG 77
            :..|| ||:.|||.|          ..|::..|||.        |...:.|.:.|.|.|......
Human   229 IPEPD-LRSMVSPVPSPTGTISVPNSCPASPRGAGS--------SSYRFVQNVTSDLQLAAEFAA 284

  Fly    78 LPISFLH------NSHRPE-KPPFSYIALIAMAISSAPNQRLTLSGIYKFIMDKFPYYRENKQGW 135
            ...|...      :|.:.| ||||||..||..|||||.:::|||||||..|...:||||...:||
Human   285 KAASEQQADTSGGDSPKDESKPPFSYAQLIVQAISSAQDRQLTLSGIYAHITKHYPYYRTADKGW 349

  Fly   136 QNSIRHNLSLNDCFVKIPRDKNTIEDNDSAGKGSYWMLD-SSASDMFEQGNYRRRRTRRQRHCGH 199
            |||||||||||..|:|:||.:      :..||||:|.:| :|.:.:.||. :|:||.|       
Human   350 QNSIRHNLSLNRYFIKVPRSQ------EEPGKGSFWRIDPASEAKLVEQA-FRKRRQR------- 400

  Fly   200 PNRYERESGKDSNDGNSSAAEIRSPSEPLSDFDIFCNERPNYSDRITDLHRQYLSVSLGFNSLFN 264
                             ..:..|:|..|||          :.|...:..|...:|...|      
Human   401 -----------------GVSCFRTPFGPLS----------SRSAPASPTHPGLMSPRSG------ 432

  Fly   265 NEARGLRPLPEIRECPDDVDASSSSSKAMQSSMELHEELHSPSAFTPPLNRRETSSSGAPVLAEA 329
                ||    :..||           .:.:.|...|:........:.|..|...|:.|:||.|:.
Human   433 ----GL----QTPEC-----------LSREGSPIPHDPEFGSKLASVPEYRYSQSAPGSPVSAQP 478

  Fly   330 FNGIKDVVDAPGS---SPVA 346
            .  |..|...|.|   .|||
Human   479 V--IMAVPPRPSSLVAKPVA 496

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
FoxL1NP_001246609.1 FH 91..185 CDD:214627 51/94 (54%)
FOXK1NP_001032242.1 Interaction with SIN3A and SIN3B. /evidence=ECO:0000250|UniProtKB:P42128 2..40
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 36..79
Required for interaction with FOXO4 and MEF2C. /evidence=ECO:0000250|UniProtKB:P42128 95..420 81/240 (34%)
FHA <102..204 CDD:224630
FHA 110..203 CDD:238017
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 287..306 3/18 (17%)
Forkhead 305..391 CDD:278670 49/91 (54%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 413..436 7/46 (15%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 676..733
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E2759_KOG2294
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D1270467at2759
OrthoFinder 1 1.000 - - FOG0000010
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R2114
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
54.850

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