DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment FoxL1 and Foxk1

DIOPT Version :9

Sequence 1:	NP_001246609.1	Gene:	FoxL1 / 38471	FlyBaseID:	FBgn0004895	Length:	365	Species:	Drosophila melanogaster
Sequence 2:	NP_951031.2	Gene:	Foxk1 / 17425	MGIID:	1347488	Length:	719	Species:	Mus musculus

Alignment Length:	366	Identity:	105/366 - (28%)
Similarity:	144/366 - (39%)	Gaps:	123/366 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly    23 LANPDYLRTQVSPNP----------LAPSAVGGAGMEGLMCGSFSPAFYYQGIDSFLALHNNIWG 77
            :..|| ||:.|||.|          ..|::..|||.        |...:.|.:.|.|.|......
Mouse   215 IPEPD-LRSLVSPIPSPTGTISVPNSCPASPRGAGS--------SSYRFVQNVTSDLQLAAEFAA 270

  Fly    78 LPISFLH------NSHRPE-KPPFSYIALIAMAISSAPNQRLTLSGIYKFIMDKFPYYRENKQGW 135
            ...|...      :|.:.| |||:||..||..|||||.:::|||||||..|...:||||...:||
Mouse   271 KAASEQQADASGGDSPKDESKPPYSYAQLIVQAISSAQDRQLTLSGIYAHITKHYPYYRTADKGW 335

  Fly   136 QNSIRHNLSLNDCFVKIPRDKNTIEDNDSAGKGSYWMLD-SSASDMFEQGNYRRRRTRRQRHCGH 199
            |||||||||||..|:|:||.:      :..||||:|.:| :|.:.:.||. :|:||.|
Mouse   336 QNSIRHNLSLNRYFIKVPRSQ------EEPGKGSFWRIDPASEAKLVEQA-FRKRRQR------- 386

  Fly   200 PNRYERESGKDSNDGNSSAAEIRSPSEPLSDFDIFCNERPNYSDRITDLHRQYLSVSLGFNSLFN 264
                             ..:..|:|..|||          :.|...:..|          ..|.:
Mouse   387 -----------------GVSCFRTPFGPLS----------SRSAPASPTH----------PGLMS 414

  Fly   265 NEARGLRPLPEI--RE---CPDDVDASSSSSKAMQSSMELHEELHSPSAFTPPLNRRETSSSGAP 324
            ..:.||: .||.  ||   .|.|.|..|..:..                   |..|...|:.|:|
Mouse   415 PRSSGLQ-TPECLSREGSPIPHDPDLGSKLASV-------------------PEYRYSQSAPGSP 459

  Fly   325 VLAEAFNGIKDVVDAPGSSPVASSNRSKTTLFTIDNIIGKP 365
            |.|:      .|:.|....|              .|::.||
Mouse   460 VSAQ------PVIMAVPPRP--------------SNLVAKP 480

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
FoxL1	NP_001246609.1	FH	91..185	CDD:214627	50/94 (53%)
Foxk1	NP_951031.2	Interaction with SIN3A and SIN3B. /evidence=ECO:0000269\|PubMed:10620510, ECO:0000269\|PubMed:22476904	2..40
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	35..67
		Required for interaction with FOXO4 and MEF2C. /evidence=ECO:0000269\|PubMed:22956541	81..406		80/240 (33%)
		FHA	<88..190	CDD:224630
		FHA	96..189	CDD:238017
		Forkhead	291..377	CDD:278670	48/91 (53%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	399..443		14/64 (22%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	665..719
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG2294
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1270467at2759
OrthoFinder	1	1.000	-	-		FOG0000010
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2114
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	6	5.850