DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment FoxL1 and Foxc1

DIOPT Version :9

Sequence 1:	NP_001246609.1	Gene:	FoxL1 / 38471	FlyBaseID:	FBgn0004895	Length:	365	Species:	Drosophila melanogaster
Sequence 2:	NP_032618.2	Gene:	Foxc1 / 17300	MGIID:	1347466	Length:	553	Species:	Mus musculus

Alignment Length:	376	Identity:	124/376 - (32%)
Similarity:	170/376 - (45%)	Gaps:	95/376 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly    20 NSMLANPDYLRTQVSPNPLAPSAVGG--AGMEGLMCGSFSPAFYYQGIDSFLALHNNIWGLPISF 82
            ||:...| ||..:.|....|.:|.||  ..|...|.....||...|...|....:......|
Mouse    11 NSLGVVP-YLGGEQSYYRAAAAAAGGGYTAMPAPMSVYSHPAHAEQYPGSMARAYGPYTPQP--- 71

  Fly    83 LHNSHRPE---KPPFSYIALIAMAISSAPNQRLTLSGIYKFIMDKFPYYRENKQGWQNSIRHNLS 144
                 :|:   |||:||||||.|||.:||::::||:|||:||||:||:||:||||||||||||||
Mouse    72 -----QPKDMVKPPYSYIALITMAIQNAPDKKITLNGIYQFIMDRFPFYRDNKQGWQNSIRHNLS 131

  Fly   145 LNDCFVKIPRDKNTIEDNDSAGKGSYWMLDSSASDMFEQGNYRRRRTRRQRHCGHPNRYER---- 205
            ||:||||:||      |:...||||||.||..:.:|||.|::.|||.|.::.....::.|:
Mouse   132 LNECFVKVPR------DDKKPGKGSYWTLDPDSYNMFENGSFLRRRRRFKKKDAVKDKEEKGRLH 190

  Fly   206 -------ESGKDSNDGNSSAAEIRSPS---EPLSDFDI-----FCNERPNYSDRITDLHRQYLS- 254
                   ::|:.........||..:|.   .|:...||     .|...|           |.||
Mouse   191 LQEPPPPQAGRQPAPAPPEQAEGSAPGPQPPPVRIQDIKTENGTCPSPP-----------QPLSP 244

  Fly   255 -VSLGFNSLFNNEARGLRPLPEIRECPDDVDASSSSSKAMQSSMELHEELHSPSAFTPPLNRRET 318
             .:||..|        ...:|:| |.||...:|.||..:...|:        |||....|:..|
Mouse   245 AAALGSGS--------AATVPKI-ESPDSSSSSLSSGSSPPGSL--------PSARPLSLDAAE- 291

  Fly   319 SSSGAPVLAEAFNGIKDVVDAPGSSPVASSNRSKTTLFTIDNII----GKP 365
                               .||...|....:.|:.  |::|||:    |.|
Mouse   292 -------------------PAPPPQPAPPPHHSQG--FSVDNIMTSLRGSP 321

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
FoxL1	NP_001246609.1	FH	91..185	CDD:214627	61/93 (66%)
Foxc1	NP_032618.2	Required for transcriptional activation. /evidence=ECO:0000250\|UniProtKB:Q12948	1..51		12/40 (30%)
		FH	78..166	CDD:214627	61/93 (66%)
		Nuclear localization signal 1 (NLS 1). /evidence=ECO:0000250\|UniProtKB:Q12948	78..93		12/14 (86%)
		Nuclear localization signal 2 (NLS 2). /evidence=ECO:0000250\|UniProtKB:Q12948	168..176		4/7 (57%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	173..326		41/199 (21%)
		Required for transcriptional inhibition. /evidence=ECO:0000250\|UniProtKB:Q12948	217..366		35/155 (23%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	356..393
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	420..466
		Required for transcriptional activation. /evidence=ECO:0000250\|UniProtKB:Q12948	466..553
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG2294
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1270467at2759
OrthoFinder	1	1.000	-	-		FOG0000010
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11829
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	5	4.920