DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment FoxL1 and Foxa3

DIOPT Version :9

Sequence 1:	NP_001246609.1	Gene:	FoxL1 / 38471	FlyBaseID:	FBgn0004895	Length:	365	Species:	Drosophila melanogaster
Sequence 2:	NP_032286.1	Gene:	Foxa3 / 15377	MGIID:	1347477	Length:	353	Species:	Mus musculus

Alignment Length:	381	Identity:	121/381 - (31%)
Similarity:	154/381 - (40%)	Gaps:	124/381 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly    10 SMLPDNEELVNSMLANPDYL--RTQVSP---NPLAPSA-----------VGGAGMEGLMCGSFSP 58
            :|.|.|..:..:.|::| |.  ..|.||   .||||.|           :|..|..|   ||.|
Mouse    33 TMAPLNSYMTLNPLSSP-YPPGGLQASPLPTGPLAPPAPTAPLGPTFPSLGTGGSTG---GSAS- 92

  Fly    59 AFYYQGIDSFLA-----LHNNIWGLPISFLHNSHRP---EKPPFSYIALIAMAISSAPNQRLTLS 115
                    .::|     :|..      .......||   .|||:|||:||.|||..||.:.||||
Mouse    93 --------GYVAPGPGLVHGK------EMAKGYRRPLAHAKPPYSYISLITMAIQQAPGKMLTLS 143

  Fly   116 GIYKFIMDKFPYYRENKQGWQNSIRHNLSLNDCFVKIPRDKNTIEDNDSAGKGSYWMLDSSASDM 180
            .||::|||.|||||||:|.|||||||:||.||||||:.|..      |..||||||.|..|:.:|
Mouse   144 EIYQWIMDLFPYYRENQQRWQNSIRHSLSFNDCFVKVARSP------DKPGKGSYWALHPSSGNM 202

  Fly   181 FEQGNYRRRRTRRQRHCGHPNRYERESGKDSNDGNS----------------SAAEIRSPSEPLS 229
            ||.|.|.||:.|.:.         .|..|..|...|                :|..:.||::|
Mouse   203 FENGCYLRRQKRFKL---------EEKAKKGNSATSASRNGTAGSATSATTTAATAVTSPAQP-- 256

  Fly   230 DFDIFCNERPNYSDRITDLHRQYLSVSLGFNSLFNNEARGLRPLPEIRECPDDVD----ASSSSS 290
                    :|..|:                              || .:..|||.    ||..||
Mouse   257 --------QPTPSE------------------------------PE-AQSGDDVGGLDCASPPSS 282

  Fly   291 KAMQSSMELHEE--LHSPSAFTPP--LNRRETSSSGAP-VLAEAFNGIKDVVDAPG 341
            ....|.:||..|  |.:|..|..|  :|...:..:..| .|...|.|.......||
Mouse   283 TPYFSGLELPGELKLDAPYNFNHPFSINNLMSEQTSTPSKLDVGFGGYGAESGEPG 338

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
FoxL1	NP_001246609.1	FH	91..185	CDD:214627	58/93 (62%)
Foxa3	NP_032286.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	52..83		8/30 (27%)
		FH	119..207	CDD:214627	58/93 (62%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	219..287		19/108 (18%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000010
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.910