DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment FoxL1 and Foxa2

DIOPT Version :9

Sequence 1:	NP_001246609.1	Gene:	FoxL1 / 38471	FlyBaseID:	FBgn0004895	Length:	365	Species:	Drosophila melanogaster
Sequence 2:	NP_001277994.1	Gene:	Foxa2 / 15376	MGIID:	1347476	Length:	465	Species:	Mus musculus

Alignment Length:	314	Identity:	101/314 - (32%)
Similarity:	142/314 - (45%)	Gaps:	59/314 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly    33 VSP--NPLAPSAVGGAGMEGLM----CGSFSPAFYYQGIDSFLALHNNIWGLPISFLHNSHRPEK 91
            :||  :||...|.|..|  ||.    ..|.||.:...|:.....        |.:: ..|:...|
Mouse   112 LSPSLSPLGGQAAGAMG--GLAPYANMNSMSPMYGQAGLSRARD--------PKTY-RRSYTHAK 165

  Fly    92 PPFSYIALIAMAISSAPNQRLTLSGIYKFIMDKFPYYRENKQGWQNSIRHNLSLNDCFVKIPRDK 156
            ||:|||:||.|||..:||:.||||.||::|||.||:||:|:|.|||||||:||.||||:|:||..
Mouse   166 PPYSYISLITMAIQQSPNKMLTLSEIYQWIMDLFPFYRQNQQRWQNSIRHSLSFNDCFLKVPRSP 230

  Fly   157 NTIEDNDSAGKGSYWMLDSSASDMFEQGNYRRRRTRRQRHCGHPNRYERESGKDSNDGNSSAAEI 221
                  |..||||:|.|...:.:|||.|.|.||:.|.:  |......:..:|..|:.|..:|...
Mouse   231 ------DKPGKGSFWTLHPDSGNMFENGCYLRRQKRFK--CEKQLALKEAAGAASSGGKKTAPGS 287

  Fly   222 RSPSEPLSDFDIFCN------ERPNYSDRITDLHRQYLSVSLGFNSLFNNEARGLRPLPEIRECP 280
            ::....|.:.....:      |.|:.|......|::.     |.:.|....|..|.| ||
Mouse   288 QASQAQLGEAAGSASETPAGTESPHSSASPCQEHKRG-----GLSELKGAPASALSP-PE----- 341

  Fly   281 DDVDASSSSSKAMQSSMELHEELHSPS-------------AFTPPLNRRETSSS 321
                .:.|..:..|::..|....|.|.             ||..|.:.....||
Mouse   342 ----PAPSPGQQQQAAAHLLGPPHHPGLPPEAHLKPEHHYAFNHPFSINNLMSS 391

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
FoxL1	NP_001246609.1	FH	91..185	CDD:214627	54/93 (58%)
Foxa2	NP_001277994.1	Forkhead_N	23..164	CDD:254796	15/62 (24%)
		FH	165..253	CDD:214627	54/93 (58%)
		DUF4799	<224..319	CDD:292674	27/102 (26%)
		HNF_C	381..454	CDD:286443	3/11 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000010
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.910