Protein Alignment FoxL1 and Foxa1

DIOPT Version :10

• Sequence 1: NP_523912.1
• Gene: FoxL1 / 38471
• FlyBaseID: FBgn0004895
• Length: 365
• Species: Drosophila melanogaster
• Sequence 2: NP_032285.2
• Gene: Foxa1 / 15375
• MGIID: 1347472
• Length: 468
• Species: Mus musculus
• Alignment Length: 415
• Identity: 122/415 - (29%)
• Similarity: 168/415 - (40%)
• Gaps: 128/415 - (30%)

  Fly     8 NGSMLPDNEELVNSMLANPDYLRTQVSPNPLAPSAVGGAGMEGLMCGSFS--------------- 57
            :|:|.|.:        .|..|..|.:... |:|.||  |||.|...|:.:
Mouse    56 SGNMTPAS--------FNMSYANTGLGAG-LSPGAV--AGMPGASAGAMNSMTAAGVTAMGTALS 109

  Fly    58 ----------PAFYYQGIDSFLALHNNIWGLPISF------------------LHNSHRPEKPPF 94
                      ||....|:..:.|..|.... |:::                  ...|:...|||:
Mouse   110 PGGMGSMGAQPATSMNGLGPYAAAMNPCMS-PMAYAPSNLGRSRAGGGGDAKTFKRSYPHAKPPY 173

  Fly    95 SYIALIAMAISSAPNQRLTLSGIYKFIMDKFPYYRENKQGWQNSIRHNLSLNDCFVKIPRDKNTI 159
            |||:||.|||..||::.||||.||::|||.|||||:|:|.|||||||:||.||||||:.|..
Mouse   174 SYISLITMAIQQAPSKMLTLSEIYQWIMDLFPYYRQNQQRWQNSIRHSLSFNDCFVKVARSP--- 235

  Fly   160 EDNDSAGKGSYWMLDSSASDMFEQGNYRRRRTRRQRHC-GHPNRYERESGKDSNDGNSSAAEIRS 223
               |..||||||.|...:.:|||.|.|.||:.|.:  | ..|.......|..|..|..|..:...
Mouse   236 ---DKPGKGSYWTLHPDSGNMFENGCYLRRQKRFK--CEKQPGAGGGSGGGGSKGGPESRKDPSG 295

  Fly   224 PSEPLSDFDIFCNERPNYSDRITDLHRQYLSVSLGFNSLFNNEARGLR--PLPEIRECPDDVDAS 286
            |..|.::               :.|||.           .:.:|..|.  |.|.....|..:|.|
Mouse   296 PGNPSAE---------------SPLHRG-----------VHGKASQLEGAPAPGPAASPQTLDHS 334

  Fly   287 SSSSKAMQSSMELHEELHSP-SAFTPPLNRRETSSSGAPVLAEAFNGIKDVVDAPGSSPV--ASS 348
            .:::....|      ||.|| |:..||:      |||...||          ..|.|.|.  .:.
Mouse   335 GATATGGAS------ELKSPASSSAPPI------SSGPGALA----------SVPPSHPAHGLAP 377

  Fly   349 NRSKTTL-----------FTIDNII 362
            :.|:..|           |:|:|::
Mouse   378 HESQLHLKGDPHYSFNHPFSINNLM 402

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
FoxL1	NP_523912.1	FH_FOX	89..186	CDD:469596	57/96 (59%)
Foxa1	NP_032285.2	Forkhead_N	17..169	CDD:369872	22/124 (18%)
		FH_FOXA1	157..268	CDD:410812	62/118 (53%)
		Essential for DNA binding	251..288		13/38 (34%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	269..396		35/174 (20%)
		HNF_C	393..457	CDD:430552	3/10 (30%)