DRSC/TRiP Functional Genomics Resources

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Protein Alignment FoxL1 and Foxc2

DIOPT Version :9

Sequence 1:NP_001246609.1 Gene:FoxL1 / 38471 FlyBaseID:FBgn0004895 Length:365 Species:Drosophila melanogaster
Sequence 2:NP_038547.2 Gene:Foxc2 / 14234 MGIID:1347481 Length:494 Species:Mus musculus


Alignment Length:387 Identity:124/387 - (32%)
Similarity:172/387 - (44%) Gaps:101/387 - (26%)


- Green bases have known domain annotations that are detailed below.


  Fly    40 PSAVG------------GAGMEGLMCGSFSPAFYYQGIDSFLALHNNIWGLPI--SFLHNSHRPE 90
            |:|:|            .||..|   |..||...|.|       |...:|..:  |:....|:|.
Mouse    10 PNALGVVPYLSEQNYYRAAGSYG---GMASPMGVYSG-------HPEQYGAGMGRSYAPYHHQPA 64

  Fly    91 ------KPPFSYIALIAMAISSAPNQRLTLSGIYKFIMDKFPYYRENKQGWQNSIRHNLSLNDCF 149
                  |||:||||||.|||.:||.:::||:|||:||||:||:|||||||||||||||||||:||
Mouse    65 APKDLVKPPYSYIALITMAIQNAPEKKITLNGIYQFIMDRFPFYRENKQGWQNSIRHNLSLNECF 129

  Fly   150 VKIPRDKNTIEDNDSAGKGSYWMLDSSASDMFEQGNYRRRRTRRQRHCGHPNRYER--------- 205
            ||:||      |:...||||||.||..:.:|||.|::.|||.|.::.....::.||         
Mouse   130 VKVPR------DDKKPGKGSYWTLDPDSYNMFENGSFLRRRRRFKKKDVPKDKEERAHLKEPPST 188

  Fly   206 -----ESGKDSNDGNSSA-------AEIRSPSEPLSDFDIFCNERPNYSDRITDLHRQYLSVSLG 258
                 .:|....||...|       :|..||:.|:    |...|..:....:....|...|...|
Mouse   189 TAKGAPTGTPVADGPKEAEKKVVVKSEAASPALPV----ITKVETLSPEGALQASPRSASSTPAG 249

  Fly   259 F--NSLFNNEARGLRPLP--------EIRECPDDVDASSSSSKA--MQSSMELHEELHSPSAFTP 311
            .  .||..:.|.....||        .:|..|...|.|.::::|  :...:.|......|:|:|.
Mouse   250 SPDGSLPEHHAAAPNGLPGFSVETIMTLRTSPPGGDLSPAAARAGLVVPPLALPYAAAPPAAYTQ 314

  Fly   312 PLNRRETSSSGA------------------------PVLAEAFNGIKDVVDAPGSSPVASSN 349
            |..:...::..|                        |.|.||   :.|....|| ||:.:.|
Mouse   315 PCAQGLEAAGSAGYQCSMRAMSLYTGAERPAHVCVPPALDEA---LSDHPSGPG-SPLGALN 372

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
FoxL1NP_001246609.1 FH 91..185 CDD:214627 62/93 (67%)
Foxc2NP_038547.2 FH 71..159 CDD:214627 62/93 (67%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 166..213 7/46 (15%)
EBP50_C 167..>257 CDD:286142 17/93 (18%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 233..267 6/33 (18%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 381..422
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E2759_KOG2294
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D1270467at2759
OrthoFinder 1 1.000 - - FOG0000010
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 1 1.100 - - O PTHR11829
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
65.920

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