DRSC/TRiP Functional Genomics Resources

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Protein Alignment FoxL1 and Foxh1

DIOPT Version :9

Sequence 1:NP_001246609.1 Gene:FoxL1 / 38471 FlyBaseID:FBgn0004895 Length:365 Species:Drosophila melanogaster
Sequence 2:NP_032015.1 Gene:Foxh1 / 14106 MGIID:1347465 Length:401 Species:Mus musculus


Alignment Length:295 Identity:76/295 - (25%)
Similarity:117/295 - (39%) Gaps:114/295 - (38%)


- Green bases have known domain annotations that are detailed below.


  Fly    88 RPEKPPFSYIALIAMAISSAPNQRLTLSGIYKFIMDKFPYYRENKQGWQNSIRHNLSLNDCFVKI 152
            |.:|||::|:|:||:.|.:||.:||.|:.|.:.:...||::|::.:||::|||||||.|.||.|:
Mouse    61 RHDKPPYTYLAMIALVIQAAPFRRLKLAQIIRQVQAVFPFFRDDYEGWKDSIRHNLSSNRCFHKV 125

  Fly   153 PRDKNTIEDNDSAGKGSYWMLDSS---ASDMFEQG-----NYRRRRTRR------QRHCGHPNRY 203
            |:|....:     .||::|.:|.|   |..:..|.     .::.|.|.|      ..:..|...|
Mouse   126 PKDPAKPQ-----AKGNFWAVDVSLIPAEALRLQNTALCRRWQNRGTHRAFAKDLSPYVLHGQPY 185

  Fly   204 ERES------------------GKDSN-------DGNSSAAEIRSPSE--------PLSDFDIFC 235
            :..|                  ||:|.       .|.|:||:..:.|:        |.|.     
Mouse   186 QPPSPPPPPREGFSIKSLLGDPGKESTWPQHPGLPGQSTAAQAGTLSKGEEGMGTGPSSS----- 245

  Fly   236 NERPNYSDRITDLHRQYLSVSLGFNSLFNNEARGLRPLPEIREC----PDDVDASSSSSKAMQSS 296
            :|.|                              |.||     |    |..::..||..:.::  
Mouse   246 SETP------------------------------LWPL-----CSLPGPTIIEGESSQGEVIR-- 273

  Fly   297 MELHEELHSPSAFTP-----PLNRRETS--SSGAP 324
                     ||..||     ||:..|.|  |.|.|
Mouse   274 ---------PSPVTPDQGSWPLHLLEDSADSRGVP 299

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
FoxL1NP_001246609.1 FH 91..185 CDD:214627 39/101 (39%)
Foxh1NP_032015.1 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 32..57
FH 64..142 CDD:238016 35/82 (43%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 179..251 15/106 (14%)
SMAD-interaction domain (SID) 307..390
Fast/FoxH1 motif 1 (FM1) 311..315
Fast/FoxH1 motif 2 (FM2) 321..327
SMAD interaction motif (SIM) 363..384
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E2759_KOG2294
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D1270467at2759
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
32.820

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