DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment FoxL1 and foxc1a

DIOPT Version :9

Sequence 1:	NP_001246609.1	Gene:	FoxL1 / 38471	FlyBaseID:	FBgn0004895	Length:	365	Species:	Drosophila melanogaster
Sequence 2:	NP_571803.1	Gene:	foxc1a / 100148408	ZFINID:	ZDB-GENE-010302-1	Length:	476	Species:	Danio rerio

Alignment Length:	381	Identity:	120/381 - (31%)
Similarity:	174/381 - (45%)	Gaps:	105/381 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly    34 SPNPLAP-----------SAVGGAGMEGLMCGSFSPAFYYQGIDSFLALHNNIWGLPISF--LHN 85
            |||.|..           .|..|.|..|:.    :|...|..     |.|:.   .|.|.  .:.
Zfish     9 SPNSLGVVPYISSDQSYYRAAAGGGYTGMP----APMTMYSH-----AAHDQ---YPASMARAYG 61

  Fly    86 SHRPE-------KPPFSYIALIAMAISSAPNQRLTLSGIYKFIMDKFPYYRENKQGWQNSIRHNL 143
            .:.|:       |||:||||||.|||.::|::::||:|||:|||::||:||:|||||||||||||
Zfish    62 PYTPQPQPKDMVKPPYSYIALITMAIQNSPDKKVTLNGIYQFIMERFPFYRDNKQGWQNSIRHNL 126

  Fly   144 SLNDCFVKIPRDKNTIEDNDSAGKGSYWMLDSSASDMFEQGNYRRRRTRRQRHCGHPNRYERESG 208
            |||:||||:||      |:...||||||.||..:.:|||.|::.|||.|.::         :::.
Zfish   127 SLNECFVKVPR------DDKKPGKGSYWTLDPDSYNMFENGSFLRRRRRFKK---------KDAM 176

  Fly   209 KDSNDGNSSAAEIRSP-------------SEPLSDFDIFCNERPNYSDRITDLHRQYLSVSLGFN 260
            ||..|.....|..|..             |:|:...||       .::..|....|.:|.:|.
Zfish   177 KDKEDRGVKEAPSRQAQPQAREQEQSVPGSQPVRIQDI-------KTENGTSTPPQAVSPTLS-- 232

  Fly   261 SLFNNEARGLRPLPEIRECPDDVDASSSSSK---------AMQSSMELHEELHSPSAFTPPLNRR 316
                       .:|:| |.||...:.||.|.         ::.|:.|.|   |...|....::..
Zfish   233 -----------TVPKI-ESPDSSSSMSSGSPHSIPSTRSLSLDSAGEQH---HQAPAQGFSVDNI 282

  Fly   317 ETSSSGAP---------VLAEAFNGIKDVVD---APGSSPVASSNRSKTTLFTIDN 360
            .||..|:|         ::|.:..||...:.   :|..|.|.||..|:.::.|..|
Zfish   283 MTSLRGSPHSSGELTPSLVAPSRTGITPTLSLNYSPNQSSVYSSPCSQNSISTTSN 338

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
FoxL1	NP_001246609.1	FH	91..185	CDD:214627	59/93 (63%)
foxc1a	NP_571803.1	Forkhead	74..160	CDD:278670	58/91 (64%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	169..271		25/134 (19%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	284..303		4/18 (22%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG2294
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1270467at2759
OrthoFinder	1	1.000	-	-		FOG0000010
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11829
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	5	4.920