DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment scrt and SCRT1

DIOPT Version :9

Sequence 1:	NP_001261390.1	Gene:	scrt / 38469	FlyBaseID:	FBgn0004880	Length:	653	Species:	Drosophila melanogaster
Sequence 2:	NP_112599.2	Gene:	SCRT1 / 83482	HGNCID:	15950	Length:	348	Species:	Homo sapiens

Alignment Length:	429	Identity:	172/429 - (40%)
Similarity:	215/429 - (50%)	Gaps:	106/429 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly   212 DRYSPLSSGQTSSERKCFSSTGATLSLPPKKKDIYRPYSLDDKPAHGYRRRVPAEEDLHAA--HA 274
            |.:|  |:...|:..:..|..||.|.......|...|.|:.|..|.....:.|:.|.::||  ..
Human    13 DAFS--SADLESAYGRARSDLGAPLHDKGYLSDYVGPSSVYDGDAEAALLKGPSPEPMYAAAVRG 75

  Fly   275 ILDLSASTAFHPPTQPHQLQQQQQQQQQQHQHHHSQQQHLAPQQHHYLPLQQQQQQQAHHTHLPT 339
            .|..:|:.:..|||...:|                                             .
Human    76 ELGPAAAGSAPPPTPRPEL---------------------------------------------A 95

  Fly   340 LEAHAHLRSTSSIAE-LAAAASVVNE---QRPASNASSASSNHMPSSPSSNSSSSSSQVQNENSN 400
            ..|..::...::::| .||.|..:.:   :|.||||.:|      ::||:.|:::
Human    96 TAAGGYINGDAAVSEGYAADAFFITDGRSRRKASNAGAA------AAPSTASAAA---------- 144

  Fly   401 TTNTNPDGDGCLQDGEHSGASGASAKTVAYTYEAFFVSDGRSKRKHVADPAAAASGVPTPDQQKT 465
                 ||||.    |...||.|.|..:............|...|   |.|.||.:|        .
Human   145 -----PDGDA----GGGGGAGGRSLGSGPGGRGGTRAGAGTEAR---AGPGAAGAG--------G 189

  Fly   466 KYTCSECGKQYATSSNLSRHKQTHRSLDSQSAKKCHTCGKAYVSMPALAMHLLTHKLSHSCGVCG 530
            ::.|.||||.||||||||||||||||||||.|::|.||||.||||||:|||||||.|.|.|||||
Human   190 RHACGECGKTYATSSNLSRHKQTHRSLDSQLARRCPTCGKVYVSMPAMAMHLLTHDLRHKCGVCG 254

  Fly   531 KLFSRPWLLQGHLRSHTGEKPYGCAHCGKAFADRSNLRAHMQTHSVDKNFECKRCHKTFALKSYL 595
            |.||||||||||:||||||||:|||||||||||||||||||||||..|:|:||||.|:|||||||
Human   255 KAFSRPWLLQGHMRSHTGEKPFGCAHCGKAFADRSNLRAHMQTHSAFKHFQCKRCKKSFALKSYL 319

  Fly   596 NKHLESACLKDEEELMMSMSLSMHDSNSESGASMASSPP 634
            |||.||||.|                 ..:|...|.:||
Human   320 NKHYESACFK-----------------GGAGGPAAPAPP 341

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
scrt	NP_001261390.1	zf-C2H2	467..489	CDD:278523	17/21 (81%)
		C2H2 Zn finger	469..489	CDD:275370	17/19 (89%)
		C2H2 Zn finger	500..520	CDD:275368	16/19 (84%)
		COG5048	520..>617	CDD:227381	72/96 (75%)
		C2H2 Zn finger	526..546	CDD:275368	17/19 (89%)
		zf-H2C2_2	539..562	CDD:290200	20/22 (91%)
		C2H2 Zn finger	554..574	CDD:275368	19/19 (100%)
		zf-C2H2	554..574	CDD:278523	19/19 (100%)
		zf-H2C2_2	566..590	CDD:290200	17/23 (74%)
		C2H2 Zn finger	582..599	CDD:275368	14/16 (88%)
SCRT1	NP_112599.2	SNAG domain. /evidence=ECO:0000250	1..20		3/8 (38%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	129..189		23/95 (24%)
		C2H2 Zn finger	224..244	CDD:275368	16/19 (84%)
		COG5048	<245..>313	CDD:227381	56/67 (84%)
		C2H2 Zn finger	250..270	CDD:275368	17/19 (89%)
		C2H2 Zn finger	278..298	CDD:275368	19/19 (100%)
		C2H2 Zn finger	306..322	CDD:275368	13/15 (87%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165147581
Domainoid	1	1.000	53	1.000	Domainoid score	I11355
eggNOG	1	0.900	-	-		E1_KOG2462
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S1379
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1332418at2759
OrthoFinder	1	1.000	-	-		FOG0000984
OrthoInspector	1	1.000	-	-		mtm8640
orthoMCL	1	0.900	-	-		OOG6_107036
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3156
SonicParanoid	1	1.000	-	-		X1445
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	11	10.630