DRSC/TRiP Functional Genomics Resources

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Protein Alignment scrt and ZIC2

DIOPT Version :10

Sequence 1:NP_523911.2 Gene:scrt / 38469 FlyBaseID:FBgn0004880 Length:653 Species:Drosophila melanogaster
Sequence 2:NP_009060.2 Gene:ZIC2 / 7546 HGNCID:12873 Length:532 Species:Homo sapiens


Alignment Length:570 Identity:123/570 - (21%)
Similarity:188/570 - (32%) Gaps:184/570 - (32%)


- Green bases have known domain annotations that are detailed below.


  Fly   112 GPSSPTAGT-TAPSPPPHSPEAATRVAGNVYNGYTRELSPLHYTAYLPRMESEITVIRAAATALV 175
            ||..|..|. :......||..||...|..:.:   ||||                        |.
Human     6 GPQFPAIGVGSFARHHHHSAAAAAAAAAEMQD---RELS------------------------LA 43

  Fly   176 AARTSGNGSGDQHLAAYQTPPSS-----------TTSSPSCSPSGAGDRYSPLSSGQTSSERKCF 229
            ||:.....|...|:.|::..|.:           |:..|...|..|....:..:.|..::....:
Human    44 AAQNGFVDSAAAHMGAFKLNPGAHELSPGQSSAFTSQGPGAYPGSAAAAAAAAALGPHAAHVGSY 108

  Fly   230 SSTGATLSLPP--KKKD-IYRPYSLDDKPAHGYRRRV--PAEEDLHAAHAILDLSASTAFHPPTQ 289
            |.       ||  ..:| ::|.....|....|.:..:  |....||.||:  |......|  |..
Human   109 SG-------PPFNSTRDFLFRSRGFGDSAPGGGQHGLFGPGAGGLHHAHS--DAQGHLLF--PGL 162

  Fly   290 PHQLQQQQQQQQQQHQHHHSQQQHLAPQQHHYLP-----LQQQQQQQAHHTHLPTLEAHAHLRST 349
            |           :||..|.||.. |..|....||     ..:|.:|.|.    |..:.:      
Human   163 P-----------EQHGPHGSQNV-LNGQMRLGLPGEVFGRSEQYRQVAS----PRTDPY------ 205

  Fly   350 SSIAELAAAASVVNEQRPAS-----NASSASSNHMPSSPSSNSSSSSSQVQNENSNTTNTNPDGD 409
                   :||.:.|:..|.:     |.::|:::|..                             
Human   206 -------SAAQLHNQYGPMNMNMGMNMAAAAAHHHH----------------------------- 234

  Fly   410 GCLQDGEHSGASGASAKTVAYTYEAFFVSDGRSKRKHVADPAAAASGVPTPDQQKTKYTCSECGK 474
               ....|.|              |||    |..|:...........:   |.::.......|.|
Human   235 ---HHHHHPG--------------AFF----RYMRQQCIKQELICKWI---DPEQLSNPKKSCNK 275

  Fly   475 QYATSSNLSRHKQT-HRSLDSQSAKKC--HTC---GKAYVSMPALAMHLLTH--KLSHSCGV--C 529
            .::|...|..|... |.....||...|  ..|   ||.:.:...|..|:..|  :....|..  |
Human   276 TFSTMHELVTHVSVEHVGGPEQSNHVCFWEECPREGKPFKAKYKLVNHIRVHTGEKPFPCPFPGC 340

  Fly   530 GKLFSRPWLLQGHLRSHTGEKPYGCAH--CGKAFADRSNLRAHMQTHSVDKNFECKRCHKTFALK 592
            ||:|:|...|:.|.|:||||||:.|..  |.:.||:.|:.:.||..|:.||.:.||.|.|::...
Human   341 GKVFARSENLKIHKRTHTGEKPFQCEFEGCDRRFANSSDRKKHMHVHTSDKPYLCKMCDKSYTHP 405

  Fly   593 SYLNKHLESACLKDEEELMMSMSLSMHDSNSESGASM--------ASSPP 634
            |.|.||::                 :|:|:.:...|.        :|:||
Human   406 SSLRKHMK-----------------VHESSPQGSESSPAASSGYESSTPP 438

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
scrtNP_523911.2 zf-C2H2 467..489 CDD:395048 5/22 (23%)
C2H2 Zn finger 469..489 CDD:275370 5/20 (25%)
C2H2 Zn finger 500..520 CDD:275368 6/24 (25%)
C2H2 Zn finger 526..546 CDD:275368 9/21 (43%)
zf-H2C2_2 539..562 CDD:463886 11/24 (46%)
C2H2 Zn finger 554..574 CDD:275368 7/21 (33%)
zf-C2H2 554..574 CDD:395048 7/21 (33%)
zf-H2C2_2 566..590 CDD:463886 9/23 (39%)
C2H2 Zn finger 582..599 CDD:275368 7/16 (44%)
ZIC2NP_009060.2 Necessary for interaction with MDFIC and transcriptional activation or repression. /evidence=ECO:0000250 100..255 43/244 (18%)
zf_ZIC 250..295 CDD:436441 7/47 (15%)
C2H2 Zn finger 307..327 CDD:275368 5/19 (26%)
SFP1 <329..413 CDD:227516 33/83 (40%)
C2H2 Zn finger 335..357 CDD:275368 9/21 (43%)
C2H2 Zn finger 365..387 CDD:275368 7/21 (33%)
C2H2 Zn finger 395..415 CDD:275368 8/36 (22%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 406..452 10/50 (20%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 475..532
Blue background indicates that the domain is not in the aligned region.

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