Protein Alignment scrt and SNAI1

DIOPT Version :10

• Sequence 1: NP_523911.2
• Gene: scrt / 38469
• FlyBaseID: FBgn0004880
• Length: 653
• Species: Drosophila melanogaster
• Sequence 2: NP_005976.2
• Gene: SNAI1 / 6615
• HGNCID: 11128
• Length: 264
• Species: Homo sapiens
• Alignment Length: 332
• Identity: 104/332 - (31%)
• Similarity: 137/332 - (41%)
• Gaps: 99/332 - (29%)

  Fly   286 PPTQPHQLQQQQQQQQQQHQHHHSQQQHLA--PQQHHYLP------------LQQQQQQQAHHTH 336
            |..:|:..:.|....:...|..:.|...||  |......|            |..|.|
Human    13 PNRKPNYSELQDSNPEFTFQQPYDQAHLLAAIPPPEILNPTASLPMLIWDSVLAPQAQ------- 70

  Fly   337 LPTLEAHAHLRSTSSIAELAAAASVVNEQRPASNASSASSNHMPSSPSSNSSSSSSQVQNENSNT 401
             |...|...|:.:..:|||.:          .|:..|...:..||.||...||.||
Human    71 -PIAWASLRLQESPRVAELTS----------LSDEDSGKGSQPPSPPSPAPSSFSS--------- 115

  Fly   402 TNTNPDGDGCLQDGEHSGASGASAKTVAYTYEAFFVSDGRSKRKHVADPAAAASGVPTPDQQKTK 466
                              .|.:|.:..||                     ||..|:
Human   116 ------------------TSVSSLEAEAY---------------------AAFPGL--------- 132

  Fly   467 YTCSECGKQYATSSNLSRHKQTHRSLDSQSAKKCHTCGKAYVSMPALAMHLLTHKLSHSCGVCGK 531
               .:..||.|..|..       :.|.::.|..|..|.|.|:|:.||.||:.:|.|...||.|||
Human   133 ---GQVPKQLAQLSEA-------KDLQARKAFNCKYCNKEYLSLGALKMHIRSHTLPCVCGTCGK 187

  Fly   532 LFSRPWLLQGHLRSHTGEKPYGCAHCGKAFADRSNLRAHMQTHSVDKNFECKRCHKTFALKSYLN 596
            .||||||||||:|:||||||:.|.||.:|||||||||||:||||..|.::|:.|.:||:..|.|:
Human   188 AFSRPWLLQGHVRTHTGEKPFSCPHCSRAFADRSNLRAHLQTHSDVKKYQCQACARTFSRMSLLH 252

  Fly   597 KHLESAC 603
            ||.||.|
Human   253 KHQESGC 259

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
scrt	NP_523911.2	zf-C2H2	467..489	CDD:395048	4/21 (19%)
		C2H2 Zn finger	469..489	CDD:275370	4/19 (21%)
		C2H2 Zn finger	500..520	CDD:275368	9/19 (47%)
		C2H2 Zn finger	526..546	CDD:275368	16/19 (84%)
		zf-H2C2_2	539..562	CDD:463886	15/22 (68%)
		C2H2 Zn finger	554..574	CDD:275368	15/19 (79%)
		zf-C2H2	554..574	CDD:395048	15/19 (79%)
		zf-H2C2_2	566..590	CDD:463886	13/23 (57%)
		C2H2 Zn finger	582..599	CDD:275368	7/16 (44%)
SNAI1	NP_005976.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..27		3/13 (23%)
		SNAG domain. /evidence=ECO:0000305|PubMed:20389281, ECO:0000305|PubMed:21300290	1..20		2/6 (33%)
		Required and sufficient for interaction with KDM1A. /evidence=ECO:0000269|PubMed:20389281, ECO:0000269|PubMed:23721412	2..7
		LATS2 binding	10..40		5/26 (19%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	86..115		11/38 (29%)
		Destruction motif	95..100		1/4 (25%)
		Required for FBXL14-triggered degradation	120..151		11/70 (16%)
		Required for nuclear localization and interaction with KPNB1, NOTCH1 and PARP1. /evidence=ECO:0000269|PubMed:21577210, ECO:0000269|PubMed:22128911	151..264		64/109 (59%)
		C2H2 Zn finger	156..176	CDD:275368	9/19 (47%)
		C2H2 Zn finger	182..202	CDD:275368	16/19 (84%)
		zf-H2C2_2	195..218	CDD:463886	15/22 (68%)
		zf-C2H2	208..230	CDD:395048	15/21 (71%)
		C2H2 Zn finger	210..230	CDD:275368	15/19 (79%)
		C2H2 Zn finger	238..255	CDD:275368	7/16 (44%)