DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment scrt and SNAI1

DIOPT Version :9

Sequence 1:	NP_001261390.1	Gene:	scrt / 38469	FlyBaseID:	FBgn0004880	Length:	653	Species:	Drosophila melanogaster
Sequence 2:	NP_005976.2	Gene:	SNAI1 / 6615	HGNCID:	11128	Length:	264	Species:	Homo sapiens

Alignment Length:	332	Identity:	104/332 - (31%)
Similarity:	137/332 - (41%)	Gaps:	99/332 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly   286 PPTQPHQLQQQQQQQQQQHQHHHSQQQHLA--PQQHHYLP------------LQQQQQQQAHHTH 336
            |..:|:..:.|....:...|..:.|...||  |......|            |..|.|
Human    13 PNRKPNYSELQDSNPEFTFQQPYDQAHLLAAIPPPEILNPTASLPMLIWDSVLAPQAQ------- 70

  Fly   337 LPTLEAHAHLRSTSSIAELAAAASVVNEQRPASNASSASSNHMPSSPSSNSSSSSSQVQNENSNT 401
             |...|...|:.:..:|||.:          .|:..|...:..||.||...||.||
Human    71 -PIAWASLRLQESPRVAELTS----------LSDEDSGKGSQPPSPPSPAPSSFSS--------- 115

  Fly   402 TNTNPDGDGCLQDGEHSGASGASAKTVAYTYEAFFVSDGRSKRKHVADPAAAASGVPTPDQQKTK 466
                              .|.:|.:..||                     ||..|:
Human   116 ------------------TSVSSLEAEAY---------------------AAFPGL--------- 132

  Fly   467 YTCSECGKQYATSSNLSRHKQTHRSLDSQSAKKCHTCGKAYVSMPALAMHLLTHKLSHSCGVCGK 531
               .:..||.|..|..       :.|.::.|..|..|.|.|:|:.||.||:.:|.|...||.|||
Human   133 ---GQVPKQLAQLSEA-------KDLQARKAFNCKYCNKEYLSLGALKMHIRSHTLPCVCGTCGK 187

  Fly   532 LFSRPWLLQGHLRSHTGEKPYGCAHCGKAFADRSNLRAHMQTHSVDKNFECKRCHKTFALKSYLN 596
            .||||||||||:|:||||||:.|.||.:|||||||||||:||||..|.::|:.|.:||:..|.|:
Human   188 AFSRPWLLQGHVRTHTGEKPFSCPHCSRAFADRSNLRAHLQTHSDVKKYQCQACARTFSRMSLLH 252

  Fly   597 KHLESAC 603
            ||.||.|
Human   253 KHQESGC 259

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
scrt	NP_001261390.1	zf-C2H2	467..489	CDD:278523	4/21 (19%)
		C2H2 Zn finger	469..489	CDD:275370	4/19 (21%)
		C2H2 Zn finger	500..520	CDD:275368	9/19 (47%)
		COG5048	520..>617	CDD:227381	54/84 (64%)
		C2H2 Zn finger	526..546	CDD:275368	16/19 (84%)
		zf-H2C2_2	539..562	CDD:290200	15/22 (68%)
		C2H2 Zn finger	554..574	CDD:275368	15/19 (79%)
		zf-C2H2	554..574	CDD:278523	15/19 (79%)
		zf-H2C2_2	566..590	CDD:290200	13/23 (57%)
		C2H2 Zn finger	582..599	CDD:275368	7/16 (44%)
SNAI1	NP_005976.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..27		3/13 (23%)
		SNAG domain. /evidence=ECO:0000305\|PubMed:20389281, ECO:0000305\|PubMed:21300290	1..20		2/6 (33%)
		Required and sufficient for interaction with KDM1A. /evidence=ECO:0000269\|PubMed:20389281, ECO:0000269\|PubMed:23721412	2..7
		LATS2 binding	10..40		5/26 (19%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	86..115		11/38 (29%)
		Destruction motif	95..100		1/4 (25%)
		Required for FBXL14-triggered degradation	120..151		11/70 (16%)
		Required for nuclear localization and interaction with KPNB1, NOTCH1 and PARP1. /evidence=ECO:0000269\|PubMed:21577210, ECO:0000269\|PubMed:22128911	151..264		64/109 (59%)
		C2H2 Zn finger	156..176	CDD:275368	9/19 (47%)
		C2H2 Zn finger	182..202	CDD:275368	16/19 (84%)
		zf-H2C2_2	195..218	CDD:404364	15/22 (68%)
		zf-C2H2	208..230	CDD:395048	15/21 (71%)
		C2H2 Zn finger	210..230	CDD:275368	15/19 (79%)
		C2H2 Zn finger	238..255	CDD:275368	7/16 (44%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG2462
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.810