DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment scrt and zbtb7a

DIOPT Version :9

Sequence 1:	NP_001261390.1	Gene:	scrt / 38469	FlyBaseID:	FBgn0004880	Length:	653	Species:	Drosophila melanogaster
Sequence 2:	XP_005170586.1	Gene:	zbtb7a / 565670	ZFINID:	ZDB-GENE-050208-583	Length:	617	Species:	Danio rerio

Alignment Length:	662	Identity:	132/662 - (19%)
Similarity:	216/662 - (32%)	Gaps:	200/662 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly    69 LEKQRT--TADAAAAAATSSEAA-----TSHSSNSSNMEASATTTTSKCWGPSSPTAGTTAPSPP 126
            |..:||  ..|...|||....||     :|.:......:..|      |.|......|......|
Zfish     3 LTGRRTDGRTDGRVAAAIGGSAAGWWKMSSGAGGRGRRDGRA------CGGAGEIEEGPVGIPFP 61

  Fly   127 PHSPEAATRVAGNVYNGYTRELSPLHYTAYLPRMESEITVIRAAATALVAARTSGNGSGDQHLAA 191
            .||.:    :.|::..   :.||.|.....|...|:|.
Zfish    62 EHSAD----LLGSLNR---QRLSGLLCDVLLVAQETEF--------------------------- 92

  Fly   192 YQTPPSSTTSSPSCSPSGAGDRYSPLSSGQTSSERKCFSSTGATLSLPPKKKDIYRPYSLDDKPA 256
                |:..:...|||..    .::..:||..:..:|.:            :.|..||.:|.....
Zfish    93 ----PAHRSVLASCSTY----FHNLFTSGPAADRQKVY------------ELDFVRPEALAALLD 137

  Fly   257 HGYRRRVPAEED-----LHAAHAILDLSA----------STAFHPPTQPHQLQQQQQQQQQQHQH 306
            ..|...:....:     |.||| :|::|.          :....||..    .:|:..::::.:.
Zfish   138 FAYTATLTVSRNSVVDILSAAH-VLEISPVQDVCTHLLDTKVLSPPAG----NEQEDNEEEEERG 197

  Fly   307 HHSQQQHLAPQQHHYLPLQQQQQQQAHHTHLPTLEAHAHLRSTSSIAELAAAASVVNEQRPA--- 368
            .:.::|.:..:...||...|:               .||..|:.|..||        ...||
Zfish   198 KNGKEQGIRLRAREYLEFFQR---------------GAHWGSSCSTPEL--------RDLPAHLH 239

  Fly   369 -SNASSASSNHMPSSPSSNSSSSSSQVQNENSNTTNTNPDGDGCLQDGEHSGASGASAKTVAYTY 432
             |..:.|..|.:|..|:...|..:..:.....:..:.|.|        |.|.....:.:.||...
Zfish   240 FSQRNGADRNGIPIGPADYYSPLAQALSQPPRDPEDENVD--------EESQDVARAREKVAEGL 296

  Fly   433 EAFFV-SDGRSKRKHVADPAAAASGVPTPDQQKTKYTCSECGKQYATSSNLSRHKQT-------- 488
            ..||. :.......|.|||.:......|.|::..:...|...:|...|....|.:.|
Zfish   297 MPFFAPTQNGHYYLHQADPKSEREVEVTGDREHNQGPASALLQQMMDSLERKRERGTTGGGGEDD 361

  Fly   489 ------------------------------------------------------HRSLDSQSAKK 499
                                                                  .|.:.|::.:|
Zfish   362 GPEGDEPDVEFYLKYFSAQPEGPTSAPISPSLAPLWPVRGNGGGNQATGGGNSGERKMRSKAFQK 426

  Fly   500 CHTCGKAYVSMPALAMHLLTH--KLSHSCGVCGKLFSRPWLLQGHLRSHTGEKPYGCAHCGKAFA 562
            |..|.|.......|..|:.||  :..:.|.:|...|:|...|:.|:|.|||||||.|..||.|||
Zfish   427 CPICSKVIQGAGKLPRHIRTHTGEKPYECAICKVRFTRQDKLKVHMRKHTGEKPYLCTQCGAAFA 491

  Fly   563 DRSNLRAHMQTHSVDKNFECKRCHKTFALKSYLNKHL-ESAC------------LKDEEELMMSM 614
            ...:|:.||:.|:..:.::|..|.|||....:|::|| :..|            ::|.|.|..|:
Zfish   492 HNYDLKNHMRVHTGLRPYQCSSCFKTFVRSDHLHRHLKKDGCNGIPSRRGRKPRIRDSELLEGSL 556

  Fly   615 SLSMHDSNSESG 626
            .|...:::.|.|
Zfish   557 ELHGPETDIERG 568

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
scrt	NP_001261390.1	zf-C2H2	467..489	CDD:278523	5/83 (6%)
		C2H2 Zn finger	469..489	CDD:275370	5/81 (6%)
		C2H2 Zn finger	500..520	CDD:275368	5/19 (26%)
		COG5048	520..>617	CDD:227381	38/111 (34%)
		C2H2 Zn finger	526..546	CDD:275368	7/19 (37%)
		zf-H2C2_2	539..562	CDD:290200	14/22 (64%)
		C2H2 Zn finger	554..574	CDD:275368	9/19 (47%)
		zf-C2H2	554..574	CDD:278523	9/19 (47%)
		zf-H2C2_2	566..590	CDD:290200	8/23 (35%)
		C2H2 Zn finger	582..599	CDD:275368	6/16 (38%)
zbtb7a	XP_005170586.1	BTB	71..175	CDD:279045	24/154 (16%)
		BTB	82..177	CDD:197585	21/142 (15%)
		COG5048	425..>488	CDD:227381	24/62 (39%)
		C2H2 Zn finger	427..447	CDD:275368	5/19 (26%)
		zf-H2C2_2	442..464	CDD:290200	6/21 (29%)
		C2H2 Zn finger	455..475	CDD:275368	7/19 (37%)
		zf-H2C2_2	468..492	CDD:290200	15/23 (65%)
		C2H2 Zn finger	483..503	CDD:275368	9/19 (47%)
		zf-H2C2_2	495..520	CDD:290200	9/24 (38%)
		C2H2 Zn finger	511..529	CDD:275368	7/17 (41%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	0	0.000