DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment scrt and Zfp398

DIOPT Version :9

Sequence 1:	NP_001261390.1	Gene:	scrt / 38469	FlyBaseID:	FBgn0004880	Length:	653	Species:	Drosophila melanogaster
Sequence 2:	NP_001102700.1	Gene:	Zfp398 / 500108	RGDID:	1562129	Length:	643	Species:	Rattus norvegicus

Alignment Length:	665	Identity:	127/665 - (19%)
Similarity:	226/665 - (33%)	Gaps:	156/665 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly   101 ASATTTTSKCWGPSSPTAGTTAPSPPPHSPEAATRVAGNVYNGYTRELSPLHYTAYLPRMESEIT 165
            |.||...:..|.....|:....|.|||        .|.|..:..|..:|.....|.:..:|.::.
  Rat     2 AEATAAPTSEWDSECLTSLQPLPLPPP--------PAANEAHLQTAAISLWTVVAAVQAIERKVE 58

  Fly   166 VIRAAATALVAARTSGNGSGDQHLAAYQTPPSSTTSSPSCSPSGAG---DRYSPLSSGQTSSERK 227
            | .:.....:..||   |:.::.||..:...:...:......:..|   ..|..|.....:.|..
  Rat    59 V-HSRRLLHLEGRT---GTAEKKLAGCEKTVTELGNQLDGKWAVLGTLLQEYGLLQRRLENLENL 119

  Fly   228 CFSSTGATLSLPPK-KKDIYR-PYSLDDKPAHGYRRRVPAEEDLHAAHAILD-----------LS 279
            ..:.....|.|||. |.||.: |.:.||...:   ...|..|.|......|.           :|
  Rat   120 LRNRNFWILRLPPGIKGDIPKVPVAFDDVSIY---FSTPEWEKLEEWQKELYKNIMKGNYESLIS 181

  Fly   280 ASTAFHPPTQPHQLQQQQQQQQQQHQHHHSQQQHLAPQQHHYLP----LQQQQQQQAHHTHLPTL 340
            ...|.:.|....|:|.:.:..........:.:....|.:...|.    |...:|::.....:|..
  Rat   182 MDYAMNQPDVLSQIQPEGEHSTDDQPRPEASEMPADPSEEPGLSTSDILSWIKQEEEPQVGVPQE 246

  Fly   341 EAHAHL-RSTSSIAELA------AAASVVNE-------QRPA------SNASSASSNHMPSSPSS 385
            ...:.| :.|.:..||.      |.||:..|       ..||      |:.:..|....|.:|..
  Rat   247 SKESELYKGTYADEELVIKAEDLARASLCPEVPVAFSAPPPAAAKDTFSDIAFKSQQCTPMAPFG 311

  Fly   386 NSSSSSSQVQNENSNTTNTN------PDGD---GCLQDGEHSGASGASAKTVAYTYEAFFVSD-- 439
            .:::...:........|...      |.|:   .|    .|.|.:  .::.:..|::....::
  Rat   312 RTATDLPEASEGQVTFTQLGSYPLPPPVGEQVFSC----HHCGKN--LSQDMLMTHQCSHAAEHP 370

  Fly   440 ----------------GRSKRKHVAD--------------PAAAASGVPTPDQQKTKYTCSECGK 474
                            |.:.:.|..:              |:.....:...:..:..:.|.:|.|
  Rat   371 LTCAQCPKHFTPQADLGSTSQDHANETPPTCPHCARTFTHPSRLTYHLRVHNSTERPFLCPDCPK 435

  Fly   475 QYATSSNLSRHKQTHRSLDSQSAKKCHTCGKAYVSMPALAMH----------------------- 516
            ::|..:.|:.|::.|.   ::...:|..||:::....:|.:|
  Rat   436 RFADQARLTSHRRAHA---TERPFRCPQCGRSFSLKISLLLHQRGHAQERPFSCPQCGIDFNGHS 497

  Fly   517 -LLTHKLSHS------CGVCGKLFSRPWLLQGHLRSHTGEKPYGCAHCGKAFADRSNLRAHMQTH 574
             |:.|::.|:      |..|.|.|.|...|..|.|.||||:|:.|.||||:|..:.:|..|.:.|
  Rat   498 ALIRHQMIHTGERPYPCTDCSKSFMRKEHLLNHRRLHTGERPFQCPHCGKSFIRKHHLMKHQRIH 562

  Fly   575 SVDKNFECKRCHKTFALKSYLNKHLES----ACLKDEEELMMSMSLSMHDSNSESGASMASSPPH 635
            :.::.:.|..|.::|..|..|..||.:    .|..|.:.     |:...|            ||.
  Rat   563 TGERPYPCAVCGRSFRYKQTLKDHLRTGHNGGCAGDRDP-----SVQPPD------------PPG 610

  Fly   636 EFLERVKLEGSGGAT 650
            ..|..::..|.|.:|
  Rat   611 PLLTALETSGLGVST 625

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
scrt	NP_001261390.1	zf-C2H2	467..489	CDD:278523	6/21 (29%)
		C2H2 Zn finger	469..489	CDD:275370	6/19 (32%)
		C2H2 Zn finger	500..520	CDD:275368	6/43 (14%)
		COG5048	520..>617	CDD:227381	34/106 (32%)
		C2H2 Zn finger	526..546	CDD:275368	8/19 (42%)
		zf-H2C2_2	539..562	CDD:290200	13/22 (59%)
		C2H2 Zn finger	554..574	CDD:275368	8/19 (42%)
		zf-C2H2	554..574	CDD:278523	8/19 (42%)
		zf-H2C2_2	566..590	CDD:290200	5/23 (22%)
		C2H2 Zn finger	582..599	CDD:275368	5/16 (31%)
Zfp398	NP_001102700.1	KRAB	143..203	CDD:214630	11/62 (18%)
		COG5048	<344..588	CDD:227381	50/252 (20%)
		C2H2 Zn finger	346..365	CDD:275368	4/24 (17%)
		C2H2 Zn finger	373..393	CDD:275368	1/19 (5%)
		C2H2 Zn finger	401..421	CDD:275368	1/19 (5%)
		C2H2 Zn finger	430..450	CDD:275368	6/19 (32%)
		C2H2 Zn finger	458..478	CDD:275368	5/19 (26%)
		C2H2 Zn finger	486..506	CDD:275368	2/19 (11%)
		C2H2 Zn finger	514..534	CDD:275368	8/19 (42%)
		C2H2 Zn finger	542..562	CDD:275368	8/19 (42%)
		C2H2 Zn finger	570..589	CDD:275368	7/18 (39%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	111	1.000	Inparanoid score	I4772
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.050