DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment scrt and Zkscan1

DIOPT Version :9

Sequence 1:	NP_001261390.1	Gene:	scrt / 38469	FlyBaseID:	FBgn0004880	Length:	653	Species:	Drosophila melanogaster
Sequence 2:	NP_001020931.1	Gene:	Zkscan1 / 498160	RGDID:	1560616	Length:	562	Species:	Rattus norvegicus

Alignment Length:	466	Identity:	123/466 - (26%)
Similarity:	176/466 - (37%)	Gaps:	118/466 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly   236 LSLPPKKKDI----YRPYSLDDKPAHGYRRRVPAEEDLHAAHAILDLSASTAFHPPTQPHQLQQQ 296
            ||:.||:..:    |||.|.::        .|...|||.     ||||....   |.|.|..:..
  Rat   105 LSILPKELQVWLQEYRPDSGEE--------AVTLLEDLE-----LDLSGQQV---PGQVHGPEML 153

  Fly   297 QQ--------QQQQQHQHHHSQQQH----------LAPQ--QHHYLPLQQQQ---QQQAHHTHLP 338
            .:        |:.....||.:.|.|          |:|:  ...::|..|.:   :.||..:.|.
  Rat   154 ARGVVPLDPVQESSSFDHHEAAQSHFKHSSRKPRLLSPRALPATHVPAPQHEGNPRDQAMASALL 218

  Fly   339 TLEAHAHLRSTSSIAELAAAASVVNEQRPASNASSASSNHMPSSPSSNSS---SSSSQVQNENSN 400
            |.::.|.::    |.::  |.|::.|:....|.:..:.|.  .|...|..   |..|:.:|.:.:
  Rat   219 TADSQAMVK----IEDM--AVSLILEEWGCQNLARRNLNR--DSRQMNLGTVFSQGSENRNGSES 275

  Fly   401 TTNTNPDGDGCLQDGEHSGASGASAKTVAYTYEAFFVSDGR-------------SKRKHVADPAA 452
            |:.....||..    .|...:|...|......|    ..||             .|.|....|..
  Rat   276 TSKAEVKGDST----SHGEIAGRFQKEFGEKRE----QQGRVIERQQKNPEEKTGKEKKAPGPPT 332

  Fly   453 AASGVPT------------------------------PDQQKTKYTCSECGKQYATSSNLSRHKQ 487
            |....||                              |...|| :.|.||||.:..||:|.|||.
  Rat   333 AKEKKPTTGERGPREKGKGLGRSFSLSANFNNTPEEIPSGAKT-HRCDECGKCFTRSSSLIRHKI 396

  Fly   488 THRSLDSQSAKKCHTCGKAYVSMPALAMHLLTH--KLSHSCGVCGKLFSRPWLLQGHLRSHTGEK 550
            .|   ..:...:|:.||||:.....|.:|...|  :..|.|..|||.||....|..|.|.|:|||
  Rat   397 IH---TGEKPYECNECGKAFSLNSNLVLHQRIHTGEKPHECNECGKAFSHSSNLILHQRIHSGEK 458

  Fly   551 PYGCAHCGKAFADRSNLRAHMQTHSVDKNFECKRCHKTFALKSYLNKHLE-------SACLKDEE 608
            ||.|..|||||:..|:|..|.:.|:.:|.:||..|.|.|...|||..|..       ..|.|..:
  Rat   459 PYECNECGKAFSQSSDLTKHQRIHTGEKPYECSECGKAFNRNSYLILHRRIHTREKPYKCTKCGK 523

  Fly   609 ELMMSMSLSMH 619
            ....|.:|::|
  Rat   524 AFTRSSTLTLH 534

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
scrt	NP_001261390.1	zf-C2H2	467..489	CDD:278523	11/21 (52%)
		C2H2 Zn finger	469..489	CDD:275370	11/19 (58%)
		C2H2 Zn finger	500..520	CDD:275368	7/19 (37%)
		COG5048	520..>617	CDD:227381	40/105 (38%)
		C2H2 Zn finger	526..546	CDD:275368	9/19 (47%)
		zf-H2C2_2	539..562	CDD:290200	14/22 (64%)
		C2H2 Zn finger	554..574	CDD:275368	9/19 (47%)
		zf-C2H2	554..574	CDD:278523	9/19 (47%)
		zf-H2C2_2	566..590	CDD:290200	8/23 (35%)
		C2H2 Zn finger	582..599	CDD:275368	7/16 (44%)
Zkscan1	NP_001020931.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..23
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	31..50
		SCAN	52..162	CDD:128708	19/72 (26%)
		SCAN	52..129	CDD:280241	8/31 (26%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	164..187		5/22 (23%)
		KRAB	226..264	CDD:279668	8/45 (18%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	261..372		19/118 (16%)
		C2H2 Zn finger	353..370	CDD:275368	0/16 (0%)
		COG5048	<355..536	CDD:227381	64/184 (35%)
		zf-C2H2	376..398	CDD:278523	11/21 (52%)
		C2H2 Zn finger	378..398	CDD:275368	11/19 (58%)
		zf-H2C2_2	390..414	CDD:290200	10/26 (38%)
		C2H2 Zn finger	406..426	CDD:275368	7/19 (37%)
		zf-H2C2_2	418..443	CDD:290200	9/24 (38%)
		C2H2 Zn finger	434..454	CDD:275368	9/19 (47%)
		zf-H2C2_2	446..471	CDD:290200	15/24 (63%)
		C2H2 Zn finger	462..482	CDD:275368	9/19 (47%)
		zf-H2C2_2	474..499	CDD:290200	9/24 (38%)
		C2H2 Zn finger	490..510	CDD:275368	8/19 (42%)
		zf-H2C2_2	502..527	CDD:290200	5/24 (21%)
		C2H2 Zn finger	518..538	CDD:275368	5/17 (29%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	111	1.000	Inparanoid score	I4772
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.050