DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment scrt and wdn

DIOPT Version :9

Sequence 1:	NP_001261390.1	Gene:	scrt / 38469	FlyBaseID:	FBgn0004880	Length:	653	Species:	Drosophila melanogaster
Sequence 2:	NP_476900.1	Gene:	wdn / 43398	FlyBaseID:	FBgn0005642	Length:	869	Species:	Drosophila melanogaster

Alignment Length:	602	Identity:	125/602 - (20%)
Similarity:	199/602 - (33%)	Gaps:	223/602 - (37%)

- Green bases have known domain annotations that are detailed below.

  Fly    55 DEEIDVVGDKFLIKLEKQRTTADAAAAAATSSEAATSHSSNSSN-----MEASATTTT------S 108
            ||.:|:                |.:|....||.:..:.:|.||.     ::.||...|      .
  Fly    58 DESLDI----------------DLSACVTISSASLVNGNSLSSTDFWRVLDESAQNNTELNLSSD 106

  Fly   109 KCWGPSSPTAGTTAPSPPPHSPEAATRVAGNVYNGYTRELSPLHYTAYLPRMESEITVIRAAATA 173
            .|....:.|:.:|.||         |..:.|            |.::     |..:|.:|
  Fly   107 VCRDDLAATSSSTVPS---------TLTSDN------------HSSS-----EFSVTFLR----- 140

  Fly   174 LVAARTSGNGSGDQHLAAYQTPPSSTTSSPSCSPSGAGDRYSPLSSGQTSSERKCFSSTGATLSL 238
                               ..||::.|:||....|.:|                    |...:.|
  Fly   141 -------------------PEPPNAFTNSPFKKTSSSG--------------------TSTPVKL 166

  Fly   239 PPKKKDIYRPYSLDDKPAHGYRRRVPAEEDLHAAHAILDLSASTAFHPPTQPHQLQQQQQQQQQQ 303
            .|                          |.||                  |.||||..|.|..|:
  Fly   167 SP--------------------------EQLH------------------QQHQLQMPQSQLLQR 187

  Fly   304 HQHHHSQQ-------QHLAPQQHHYLPLQQQQQQQAHHTHL--PTLEAHAHLRSTSSIAELAAAA 359
            .....:..       :...|::.| .|.|...:.:...:.|  |:.......:|..|:|:   ||
  Fly   188 KPKLPAATAVRLKVFKEEPPEEKH-PPEQVVTKVEVCESELLPPSFTIFQQAKSAESVAD---AA 248

  Fly   360 SVVNEQRPASNASSASSNHMPSSPSSNSSSSSSQVQNENSNTTNTNPDGDGCLQDGEHSGASGAS 424
            |:     |...||......:..:|...                        ||.      .:|..
  Fly   249 SM-----PPPAASETKPLEVDPAPLHK------------------------CLD------CNGLL 278

  Fly   425 AKTVAYTYEAFFVSDGRSKRKHVADPAAAASGVPTPDQQKTKYTCSECGKQYATSSNLSRHKQTH 489
            .:|                ...||...|||      .:.:..|.||||.:::...:.|.:|.:||
  Fly   279 LET----------------PDEVAKHEAAA------HRLRLTYRCSECQREFELLAGLKKHLKTH 321

  Fly   490 RSLDSQSA-KKCHTCGKAYVSMPALAMHLLTH--KLSHSCGVCGKLFSRPWLLQGHLRSHTGEKP 551
            |:...:.. |||..|||. :.:.::.||...|  ...:.|.:||:.|.:...|..|.|.|:.|||
  Fly   322 RTEGRKDTWKKCPDCGKC-LKLGSMWMHRKIHSDNKKYQCDICGQKFVQKINLTHHARIHSSEKP 385

  Fly   552 YGCAHCGKAFADRSNLRAHMQTHSVDKNFECKRCHKTF----ALKSYLNKHLES---ACLKDEEE 609
            |.|..|.|.|.:||:|:.|.:.|:..:::.|::|.|.:    .||.:...|||.   ||...::.
  Fly   386 YECPECQKRFQERSHLQRHQKYHAQTRSYRCEKCGKMYKTERCLKVHNLVHLEQRPFACTVCDKS 450

  Fly   610 LMMSMSLSMHDSNSESG 626
            .:.:..|..| ||..:|
  Fly   451 FISNSKLKQH-SNIHTG 466

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
scrt	NP_001261390.1	zf-C2H2	467..489	CDD:278523	7/21 (33%)
		C2H2 Zn finger	469..489	CDD:275370	6/19 (32%)
		C2H2 Zn finger	500..520	CDD:275368	6/19 (32%)
		COG5048	520..>617	CDD:227381	32/105 (30%)
		C2H2 Zn finger	526..546	CDD:275368	7/19 (37%)
		zf-H2C2_2	539..562	CDD:290200	11/22 (50%)
		C2H2 Zn finger	554..574	CDD:275368	8/19 (42%)
		zf-C2H2	554..574	CDD:278523	8/19 (42%)
		zf-H2C2_2	566..590	CDD:290200	6/27 (22%)
		C2H2 Zn finger	582..599	CDD:275368	5/20 (25%)
wdn	NP_476900.1	C2H2 Zn finger	301..321	CDD:275368	6/19 (32%)
		RPB9	333..425	CDD:224510	31/92 (34%)
		C2H2 Zn finger	333..352	CDD:275368	6/19 (32%)
		zf-H2C2_2	344..369	CDD:290200	7/24 (29%)
		zf-C2H2	358..380	CDD:278523	7/21 (33%)
		C2H2 Zn finger	360..380	CDD:275368	7/19 (37%)
		zf-H2C2_2	372..395	CDD:290200	11/22 (50%)
		zf-C2H2	386..408	CDD:278523	9/21 (43%)
		C2H2 Zn finger	388..436	CDD:275368	14/47 (30%)
		zf-H2C2_2	400..425	CDD:290200	6/24 (25%)
		C2H2 Zn finger	416..433	CDD:275368	5/16 (31%)
		zf-H2C2_2	429..453	CDD:290200	7/23 (30%)
		C2H2 Zn finger	444..464	CDD:275368	5/20 (25%)
		zf-H2C2_2	457..481	CDD:290200	5/11 (45%)
		C2H2 Zn finger	472..493	CDD:275368
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45457082
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	1	0.930