DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment scrt and esg

DIOPT Version :9

Sequence 1:	NP_001261390.1	Gene:	scrt / 38469	FlyBaseID:	FBgn0004880	Length:	653	Species:	Drosophila melanogaster
Sequence 2:	NP_476600.1	Gene:	esg / 34903	FlyBaseID:	FBgn0001981	Length:	470	Species:	Drosophila melanogaster

Alignment Length:	644	Identity:	176/644 - (27%)
Similarity:	235/644 - (36%)	Gaps:	247/644 - (38%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 LIAKKWKAYPWLDRTEDTSNQQQQQEQSAPNSPREL-------------EEL------------- 43
            |:.|.:...|...|..:...:..|...:.||.|::|             |||
  Fly     8 LVEKNYSKCPLKKRPVNYQFEAPQNHSNTPNEPQDLCVKKMEILEENPSEELINVSDCCEDEGVD 72

  Fly    44 -------HLKSRRSTLDDDEEIDVVGDKFLIKLEKQRTTADAAAAAATSSEAATSHSSNSSNMEA 101
                   |::      ::||::||..|.     :..:|.|.|.||||..:.||
  Fly    73 VDHTDDEHIE------EEDEDVDVDVDS-----DPNQTQAAALAAAAAVAAAA------------ 114

  Fly   102 SATTTTSKCWGPSSPTAGTTAPSPP-PHSPEAATRVAGNVYNGYTRELSPLHYTAYLPRMESEIT 165
                           .|....|:|. |..|          :|.:  .:||  |||...|     |
  Fly   115 ---------------AASVVVPTPTYPKYP----------WNNF--HMSP--YTAEFYR-----T 145

  Fly   166 VIRAAATALVAARTSGNGSGDQHLAAYQTPPSSTTSSPSCSPSGAGDRYSPLSSGQTSSERKCFS 230
            :               |..|.|.|     |......:|| |||                     .
  Fly   146 I---------------NQQGHQIL-----PLRGDLIAPS-SPS---------------------D 168

  Fly   231 STGATLSLPPKKKDIYRPYSLDDKPAHGYRRRVPAEEDLHA-AHAILDLSASTAFHPPTQPHQLQ 294
            |.|   ||.|              |.|.|         ||. |.::.....|...|.|
  Fly   169 SLG---SLSP--------------PPHHY---------LHGRASSVSPPMRSEIIHRP------- 200

  Fly   295 QQQQQQQQQHQHHHSQQQHLAPQQHHYLPLQQQQQQQAHHTHLPTLEAHAHLRSTSSIAELAAAA 359
                               :..:||.:||..|.       ...|:|..:.|..
  Fly   201 -------------------IGVRQHRFLPYPQM-------PGYPSLGGYTHTH------------ 227

  Fly   360 SVVNEQRPASNASSASSNHMPSSPSSNSSSSSS-----QVQNENSN-TTNTNPDGDGCLQDGEHS 418
               :...|.|.|.|.:|.:...|.:..||.|||     .::::|.| ..||:       |.||.
  Fly   228 ---HHHAPISPAYSENSYYSMRSMTPESSCSSSLPEDLSLKHKNLNLNLNTS-------QPGEQ- 281

  Fly   419 GASGASAKTVAYTYEAFFVSDGRSKRKHVADPAAAASGVPTPDQQKTKYTCSECGKQYATSSNLS 483
                |:|||...:.|..              |.|:|.   ....|..:|.|.:|.|.|:|.|.|:
  Fly   282 ----AAAKTGDMSPETM--------------PNASAK---KDKNQPPRYQCPDCQKSYSTFSGLT 325

  Fly   484 RHKQTH-RSLDSQSAKK---CHTCGKAYVSMPALAMHLLTHKLSHSCGVCGKLFSRPWLLQGHLR 544
            :|:|.| .:.:....||   |..|.|.|||:.||.||:.||.|...|.:|||.||||||||||:|
  Fly   326 KHQQFHCPAAEGNQVKKSFSCKDCDKTYVSLGALKMHIRTHTLPCKCNLCGKAFSRPWLLQGHIR 390

  Fly   545 SHTGEKPYGCAHCGKAFADRSNLRAHMQTHSVDKNFECKRCHKTFALKSYLNKHLESAC 603
            :||||||:.|.||.:|||||||||||:||||..|.:.|..|.|||:..|.|.||.|..|
  Fly   391 THTGEKPFSCQHCHRAFADRSNLRAHLQTHSDIKKYSCTSCSKTFSRMSLLTKHSEGGC 449

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
scrt	NP_001261390.1	zf-C2H2	467..489	CDD:278523	10/21 (48%)
		C2H2 Zn finger	469..489	CDD:275370	9/19 (47%)
		C2H2 Zn finger	500..520	CDD:275368	10/19 (53%)
		COG5048	520..>617	CDD:227381	53/84 (63%)
		C2H2 Zn finger	526..546	CDD:275368	15/19 (79%)
		zf-H2C2_2	539..562	CDD:290200	15/22 (68%)
		C2H2 Zn finger	554..574	CDD:275368	15/19 (79%)
		zf-C2H2	554..574	CDD:278523	15/19 (79%)
		zf-H2C2_2	566..590	CDD:290200	14/23 (61%)
		C2H2 Zn finger	582..599	CDD:275368	8/16 (50%)
esg	NP_476600.1	zf-C2H2	309..331	CDD:278523	10/21 (48%)
		C2H2 Zn finger	311..331	CDD:275370	9/19 (47%)
		zf-C2H2	344..366	CDD:278523	10/21 (48%)
		C2H2 Zn finger	346..366	CDD:275368	10/19 (53%)
		zf-C2H2	370..392	CDD:278523	15/21 (71%)
		C2H2 Zn finger	372..392	CDD:275368	15/19 (79%)
		zf-H2C2_2	385..408	CDD:290200	15/22 (68%)
		zf-C2H2	398..420	CDD:278523	15/21 (71%)
		C2H2 Zn finger	400..420	CDD:275368	15/19 (79%)
		C2H2 Zn finger	428..444	CDD:275368	7/15 (47%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45457099
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG2462
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	3	2.740