DRSC/TRiP Functional Genomics Resources

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Protein Alignment scrt and Snai1

DIOPT Version :9

Sequence 1:NP_001261390.1 Gene:scrt / 38469 FlyBaseID:FBgn0004880 Length:653 Species:Drosophila melanogaster
Sequence 2:NP_035557.1 Gene:Snai1 / 20613 MGIID:98330 Length:264 Species:Mus musculus


Alignment Length:314 Identity:106/314 - (33%)
Similarity:133/314 - (42%) Gaps:102/314 - (32%)


- Green bases have known domain annotations that are detailed below.


  Fly   320 HYLPLQ--------QQQQQQAH-HTHLPTLEAHAHLRSTSSIAELAAAASVVNEQRPA------- 368
            :|..||        ||...||| ...:|..|.   |...:|:..|...:.:|.:.||.       
Mouse    18 NYSELQDACVEFTFQQPYDQAHLLAAIPPPEV---LNPAASLPTLIWDSLLVPQVRPVAWATLPL 79

  Fly   369 ------------SNASSASSNHMPSSPSSNSSSSSSQVQNENSNTTNTNPDGDGCLQDGEHSGAS 421
                        |:..|..|:..||.||...||.||                         :.||
Mouse    80 RESPKAVELTSLSDEDSGKSSQPPSPPSPAPSSFSS-------------------------TSAS 119

  Fly   422 GASAKTVAYTYEAFFVSDGRSKRKHVADPAAAASGVPTPDQQKTKYTCSECGKQYATSSNLSRHK 486
            ...|       |||....|                            ..:..||.|   .||..|
Mouse   120 SLEA-------EAFIAFPG----------------------------LGQLPKQLA---RLSVAK 146

  Fly   487 QTHRSLDSQSAK--KCHTCGKAYVSMPALAMHLLTHKLSHSCGVCGKLFSRPWLLQGHLRSHTGE 549
                  |.||.|  .|..|.|.|:|:.||.||:.:|.|...|..|||.||||||||||:|:||||
Mouse   147 ------DPQSRKIFNCKYCNKEYLSLGALKMHIRSHTLPCVCTTCGKAFSRPWLLQGHVRTHTGE 205

  Fly   550 KPYGCAHCGKAFADRSNLRAHMQTHSVDKNFECKRCHKTFALKSYLNKHLESAC 603
            ||:.|:||.:|||||||||||:||||..|.::|:.|.:||:..|.|:||.||.|
Mouse   206 KPFSCSHCNRAFADRSNLRAHLQTHSDVKRYQCQACARTFSRMSLLHKHQESGC 259

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
scrtNP_001261390.1 zf-C2H2 467..489 CDD:278523 6/21 (29%)
C2H2 Zn finger 469..489 CDD:275370 6/19 (32%)
C2H2 Zn finger 500..520 CDD:275368 9/19 (47%)
COG5048 520..>617 CDD:227381 53/84 (63%)
C2H2 Zn finger 526..546 CDD:275368 15/19 (79%)
zf-H2C2_2 539..562 CDD:290200 15/22 (68%)
C2H2 Zn finger 554..574 CDD:275368 15/19 (79%)
zf-C2H2 554..574 CDD:278523 15/19 (79%)
zf-H2C2_2 566..590 CDD:290200 13/23 (57%)
C2H2 Zn finger 582..599 CDD:275368 7/16 (44%)
Snai1NP_035557.1 SNAG domain. /evidence=ECO:0000305 1..20 0/1 (0%)
Required and sufficient for interaction with KDM1A. /evidence=ECO:0000250|UniProtKB:O95863 2..7
LATS2 binding. /evidence=ECO:0000250 10..40 7/21 (33%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 85..116 11/55 (20%)
Destruction motif 95..100 1/4 (25%)
Required for FBXL14-triggered degradation. /evidence=ECO:0000250 120..151 13/74 (18%)
Required for nuclear localization and interaction with KPNB1, NOTCH1 and PARP1. /evidence=ECO:0000250 151..264 63/109 (58%)
C2H2 Zn finger 156..176 CDD:275368 9/19 (47%)
COG5048 <177..>253 CDD:227381 47/75 (63%)
C2H2 Zn finger 182..202 CDD:275368 15/19 (79%)
zf-H2C2_2 195..218 CDD:290200 15/22 (68%)
zf-C2H2 208..230 CDD:278523 15/21 (71%)
C2H2 Zn finger 210..230 CDD:275368 15/19 (79%)
C2H2 Zn finger 238..255 CDD:275368 7/16 (44%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG2462
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
32.810

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