Protein Alignment CG12605 and GLIS2

DIOPT Version :10

• Sequence 1: NP_647845.2
• Gene: CG12605 / 38468
• FlyBaseID: FBgn0035481
• Length: 619
• Species: Drosophila melanogaster
• Sequence 2: NP_115964.2
• Gene: GLIS2 / 84662
• HGNCID: 29450
• Length: 524
• Species: Homo sapiens
• Alignment Length: 300
• Identity: 77/300 - (25%)
• Similarity: 115/300 - (38%)
• Gaps: 80/300 - (26%)

  Fly   320 SPLTPP-----NSDHSSDVD--------IDMSSSSESGLQQWGKPN------PQQNQQ------- 358
            ||.:||     ||.....|:        :|:|.|..|||.   .||      |::...
Human    51 SPGSPPSGFLLNSKFPEKVEGRFSAAPLVDLSLSPPSGLD---SPNGSSSLSPERQGNGDLPPVP 112

  Fly   359 RASALKMCLNMLDGRTKASKAAAVTKQDRQEPMQPRPKSAQSNASSGGG-----PPSE---PPEN 415
            .||..:. |..|||                     .|.|.|.....|.|     |.|.   ||::
Human   113 SASDFQP-LRYLDG---------------------VPSSFQFFLPLGSGGALHLPASSFLTPPKD 155

  Fly   416 PAASLGHSSSGNGENYAKRKRGCYKCCECGKQYATSSNLSRHKQTHRSLDSQSAKKC---NTC-- 475
            ...|         .:....|:...:..:|.:.:....:|..|...:.....:.|..|   ..|
Human   156 KCLS---------PDLPLPKQLVCRWAKCNQLFELLQDLVDHVNDYHVKPEKDAGYCCHWEGCAR 211

  Fly   476 -GKAYVSMPALAMHLLTH--KLSHSCDICGKLFSRPWLLQGHLRSHTGEKPYACVH--CGKAFAD 535
             |:.:.:...:.:|:.||  :..|.|..|.|.|||...|:.|.|||||||||.|.:  |.|.:::
Human   212 HGRGFNARYKMLIHIRTHTNEKPHRCPTCSKSFSRLENLKIHNRSHTGEKPYVCPYEGCNKRYSN 276

  Fly   536 RSNLRAHMQTHSGDKNFKCHR--CNKTFALKSYLNKHLES 573
            .|:...|.:||..||.:.|..  |:|.:...|.|.||:::
Human   277 SSDRFKHTRTHYVDKPYYCKMPGCHKRYTDPSSLRKHIKA 316

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG12605	NP_647845.2	COG5048	283..>561	CDD:227381	73/286 (26%)
		zf-C2H2	439..461	CDD:395048	3/21 (14%)
		C2H2 Zn finger	441..461	CDD:275370	3/19 (16%)
		C2H2 Zn finger	472..492	CDD:275368	4/25 (16%)
		zf-C2H2	496..518	CDD:395048	10/21 (48%)
		C2H2 Zn finger	498..518	CDD:275368	9/19 (47%)
		zf-H2C2_2	511..534	CDD:463886	14/24 (58%)
		zf-C2H2	524..546	CDD:395048	6/23 (26%)
		C2H2 Zn finger	526..546	CDD:275368	5/21 (24%)
		zf-H2C2_2	538..562	CDD:463886	8/25 (32%)
		C2H2 Zn finger	554..571	CDD:275368	6/18 (33%)
GLIS2	NP_115964.2	Interaction with CTNND1. /evidence=ECO:0000250	35..174		33/156 (21%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	39..62		4/10 (40%)
		Transcription activation. /evidence=ECO:0000250	71..137		18/90 (20%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	84..114		7/32 (22%)
		Transcription repression. /evidence=ECO:0000250	148..171		4/31 (13%)
		C2H2 Zn finger	213..229	CDD:275368	2/15 (13%)
		COG5048	233..>327	CDD:227381	34/83 (41%)
		C2H2 Zn finger	237..257	CDD:275368	9/19 (47%)
		C2H2 Zn finger	265..287	CDD:275368	5/21 (24%)
		C2H2 Zn finger	295..317	CDD:275368	7/21 (33%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	439..480