DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG12605 and Mynn

DIOPT Version :9

Sequence 1:	NP_001261387.1	Gene:	CG12605 / 38468	FlyBaseID:	FBgn0035481	Length:	619	Species:	Drosophila melanogaster
Sequence 2:	NP_085034.2	Gene:	Mynn / 80732	MGIID:	1931415	Length:	610	Species:	Mus musculus

Alignment Length:	650	Identity:	132/650 - (20%)
Similarity:	223/650 - (34%)	Gaps:	198/650 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly     9 NRNKIQTIA------YASASKKYVPGGSGSTLSSGSVSASG------------ADLQSW------ 49
            :||.:.:.:      |.|.|:..|      .|....|.|.|            .:|.||
Mouse    38 HRNVLASFSEYFGAIYRSTSENNV------FLDQSQVKADGFQKLLEFIYTGTLNLDSWNVKEIH 96

  Fly    50 ------RRPKPRTSGKVKFDD----KSPLTASSVLKNANGNGLGTGGKSPLKSLAKRNSRSILKR 104
                  :..:..|..|:|.:|    .||  :|:.:.:..||             .:.|.::.|
Mouse    97 QAADYLKVEEVVTKCKIKMEDFAFIASP--SSTEISSITGN-------------IELNQQACL-- 144

  Fly   105 EIIDLDDEDGEEQEDQLCEHLEWSAAQSLVQMNSSKQEKQRRAGTTGSPATVAAPVSASVSLRRP 169
              :.|.|.:..|:.:...:.::.:.....:...||:.:|:::|.::..|....|....|..|
Mouse   145 --LTLRDYNNREKSEVSTDSVQANPKPRALTKKSSQSKKKKKAFSSQKPGQSKAVQYPSDVL--- 204

  Fly   170 VGRAPAEDGKVIFYAPPASASGSPRQPEPVALKRERERDKEREREKERERDRMREQQLVAATAAA 234
                  |...|..:...:..|      .||.                        :|::....::
Mouse   205 ------ESASVELFLETSKLS------SPVV------------------------EQIIQGNDSS 233

  Fly   235 SIYRGRSVEETEAAHDLLSLSQSLPPLIPPCVVTIMKQEQEQLRSPEIQE--ISNSASSRSPQST 297
            .:.....||.|....|::.            .||:.::.::......::|  :||.||.:||..
Mouse   234 ELELTSVVENTFPTQDIVQ------------TVTVKRKRRKSQSHCALKEHSMSNIASVKSPYE- 285

  Fly   298 IRFIGSSSYDLMGGSSEGANNCSPLTPPNSDHSSDVDIDMSSSSESGLQQW-----GKPNPQQNQ 357
               :.::..:|....|:....|:......|:.||   :........|::.:     ||...|.||
Mouse   286 ---LENAGEELDARFSKAKPMCNTCGKVFSEASS---LRRHMRIHKGVKPYVCHLCGKAFTQCNQ 344

  Fly   358 ----------QRASALKMCLNMLDGRTKASKAAAVTKQDRQEPMQPRPKSAQSNASSGGGPPSEP 412
                      :|....::|     .:..|.|...|.
Mouse   345 LKTHVRTHTGERPYKCELC-----DKGFAQKCQLVF----------------------------- 375

  Fly   413 PENPAASLGHSSSGNGENYAKRKRGCYKCCECGKQYATSSNLSRHKQTHRSLDSQSAKK---CNT 474
                     ||...:||...      |||..|..|:||||||..|.:.|      |.:|   |:.
Mouse   376 ---------HSRMHHGEEKP------YKCDVCNLQFATSSNLKIHARKH------SGEKPYVCDR 419

  Fly   475 CGKAYVSMPALAMHLLTH--KLSHSCDICGKLFSRPWLLQGHLRSHTGEKPYACVHCGKAFADRS 537
            ||:.:.....|..|:..|  :..:.||.|||.|:....|..|.|.|||||||.|..|||:|....
Mouse   420 CGQRFAQASTLTYHVRRHTGEKPYVCDTCGKAFAVSSSLITHSRKHTGEKPYICGICGKSFISSG 484

  Fly   538 NLRAHMQTHSGDKNFKCHRCNKTFALKSYLNKHLESACLRDAGAIDQGKGLEEEDDDCSKQDELE 602
            .|..|.::|:|::.|.|..|..::.....|.||....    ....|:......:|...|:||.::
Mouse   485 ELNKHFRSHTGERPFICELCGNSYTDIKNLKKHKTKV----HSGTDKNPDCSVDDHAVSEQDSVQ 545

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG12605	NP_001261387.1	zf-C2H2	439..461	CDD:278523	12/21 (57%)
		C2H2 Zn finger	441..461	CDD:275370	10/19 (53%)
		C2H2 Zn finger	472..492	CDD:275368	5/19 (26%)
		COG5048	492..>570	CDD:227381	30/79 (38%)
		zf-C2H2	496..518	CDD:278523	9/21 (43%)
		C2H2 Zn finger	498..518	CDD:275368	9/19 (47%)
		zf-H2C2_2	511..534	CDD:290200	14/22 (64%)
		zf-C2H2	524..546	CDD:278523	8/21 (38%)
		C2H2 Zn finger	526..546	CDD:275368	7/19 (37%)
		zf-H2C2_2	538..562	CDD:290200	7/23 (30%)
		C2H2 Zn finger	554..571	CDD:275368	4/16 (25%)
Mynn	NP_085034.2	BTB	14..115	CDD:279045	15/82 (18%)
		BTB	25..118	CDD:197585	16/85 (19%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	156..199		6/42 (14%)
		Nuclear localization signal. /evidence=ECO:0000255	174..190		4/15 (27%)
		Nuclear localization signal. /evidence=ECO:0000255	257..262		0/4 (0%)
		C2H2 Zn finger	304..324	CDD:275368	4/22 (18%)
		zf-C2H2	304..324	CDD:278523	4/22 (18%)
		zf-H2C2_2	316..341	CDD:290200	4/27 (15%)
		C2H2 Zn finger	332..352	CDD:275368	5/19 (26%)
		zf-H2C2_2	345..369	CDD:290200	2/28 (7%)
		C2H2 Zn finger	360..380	CDD:275368	6/62 (10%)
		C2H2 Zn finger	389..409	CDD:275368	10/19 (53%)
		zf-H2C2_2	401..426	CDD:290200	9/30 (30%)
		C2H2 Zn finger	417..437	CDD:275368	5/19 (26%)
		zf-H2C2_2	430..453	CDD:290200	8/22 (36%)
		C2H2 Zn finger	445..465	CDD:275368	9/19 (47%)
		zf-H2C2_2	457..482	CDD:290200	15/24 (63%)
		C2H2 Zn finger	473..493	CDD:275368	7/19 (37%)
		C2H2 Zn finger	501..522	CDD:275368	5/24 (21%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	519..548		5/30 (17%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	0	0.000