DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG12605 and ZBTB16

DIOPT Version :9

Sequence 1:	NP_001261387.1	Gene:	CG12605 / 38468	FlyBaseID:	FBgn0035481	Length:	619	Species:	Drosophila melanogaster
Sequence 2:	NP_001018011.1	Gene:	ZBTB16 / 7704	HGNCID:	12930	Length:	673	Species:	Homo sapiens

Alignment Length:	629	Identity:	137/629 - (21%)
Similarity:	213/629 - (33%)	Gaps:	214/629 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly    55 RTSGKVKFDDKSPLTASSVLKNANGNGLGTGGKSPLKSLAKRNSRSILKREIIDL---------- 109
            |.|.....|..||.|...:|:.|.        .:.|::.|:.....:...||:::
Human    65 RNSQHYTLDFLSPKTFQQILEYAY--------TATLQAKAEDLDDLLYAAEILEIEYLEEQCLKM 121

  Fly   110 -------DDED---------GEEQEDQLCEHLEWSAAQSLVQMNSSKQE---------------K 143
                   ||.|         .||:||:...:|:    ...:..:||::.               .
Human   122 LETIQASDDNDTEATMADGGAEEEEDRKARYLK----NIFISKHSSEESGYASVAGQSLPGPMVD 182

  Fly   144 QRRAGTTGSPATVAAPVSASVSLRRPVGRAPAEDGKVIFYAPPA-----SASGSPRQPEPVALKR 203
            |..:.:|....:..:|..|:|.....:|::..: |.:   .|||     :.:|..|.|....:|.
Human   183 QSPSVSTSFGLSAMSPTKAAVDSLMTIGQSLLQ-GTL---QPPAGPEEPTLAGGGRHPGVAEVKT 243

  Fly   204 ERER----------------------DKEREREKERERDRMREQQLVAATAAASIYRGRSVEETE 246
            |..:                      ||..||.||......|...:   |:|..::.||  ||:
Human   244 EMMQVDEVPSQDSPGAAESSISGGMGDKVEERGKEGPGTPTRSSVI---TSARELHYGR--EES- 302

  Fly   247 AAHDLLSLSQSLPPLIPPCVVTIMKQEQEQLRSPEIQEISNSASSRSPQSTIRFIGSSSYDLMGG 311
                    ::.:|   ||.                  |...:.:.| |:
Human   303 --------AEQVP---PPA------------------EAGQAPTGR-PE---------------- 321

  Fly   312 SSEGANNCSPLTPPNS---------DHSSDVDIDMSSSSESGLQQWGKPNPQQNQQRASALKMCL 367
                    .|..||..         :|.:|..:.|.||..|||          :.|.|.|:.|..
Human   322 --------HPAPPPEKHLGIYSVLPNHKADAVLSMPSSVTSGL----------HVQPALAVSMDF 368

  Fly   368 NMLDG--------RTKASKAAAVTKQDRQEPMQPRPKSAQSNASSGGGPPSEPPENPAASLGHSS 424
            :...|        |...||...:.     ..|:...::.....|..|   .|.|:|.|.......
Human   369 STYGGLLPQGFIQRELFSKLGELA-----VGMKSESRTIGEQCSVCG---VELPDNEAVEQHRKL 425

  Fly   425 SGNGENYAKRKRGC--------------------------YKCCECGKQYATSSNLSRHKQTHRS 463
            ....:.|     ||                          :.|.:||.|::....|..|:|||..
Human   426 HSGMKTY-----GCELCGKRFLDSLRLRMHLLAHSAGAKAFVCDQCGAQFSKEDALETHRQTHTG 485

  Fly   464 LDSQSAKKCNTCGKAYVSMPALAMHLLTHK--LSHSCDICGKLFSRPWLLQGHLRSHTGEKPYAC 526
            .|  .|..|..|||.:.:..||..|:..|.  .|:.|..|.:.|.....|:.|||||||:.||.|
Human   486 TD--MAVFCLLCGKRFQAQSALQQHMEVHAGVRSYICSECNRTFPSHTALKRHLRSHTGDHPYEC 548

  Fly   527 VHCGKAFADRSNLRAHMQTHSGDKNFKCHRCNKTFALKSYLNKH 570
            ..||..|.|.|.|::|.:.|:|:|.::|:.|.|.|:||..|..|
Human   549 EFCGSCFRDESTLKSHKRIHTGEKPYECNGCGKKFSLKHQLETH 592

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG12605	NP_001261387.1	zf-C2H2	439..461	CDD:278523	7/21 (33%)
		C2H2 Zn finger	441..461	CDD:275370	7/19 (37%)
		C2H2 Zn finger	472..492	CDD:275368	7/19 (37%)
		COG5048	492..>570	CDD:227381	33/79 (42%)
		zf-C2H2	496..518	CDD:278523	7/21 (33%)
		C2H2 Zn finger	498..518	CDD:275368	7/19 (37%)
		zf-H2C2_2	511..534	CDD:290200	13/22 (59%)
		zf-C2H2	524..546	CDD:278523	9/21 (43%)
		C2H2 Zn finger	526..546	CDD:275368	8/19 (42%)
		zf-H2C2_2	538..562	CDD:290200	8/23 (35%)
		C2H2 Zn finger	554..571	CDD:275368	8/17 (47%)
ZBTB16	NP_001018011.1	BTB	25..125	CDD:306997	12/67 (18%)
		Herpes_ICP4_C	177..>327	CDD:332854	35/213 (16%)
		Interaction with RUNX1T1. /evidence=ECO:0000269\|PubMed:10688654	200..300		23/108 (21%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	215..236		6/24 (25%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	249..332		22/142 (15%)
		C2H2 Zn finger	406..426	CDD:275368	6/22 (27%)
		C2H2 Zn finger	434..454	CDD:275368	1/19 (5%)
		COG5048	<448..622	CDD:227381	52/147 (35%)
		C2H2 Zn finger	463..483	CDD:275368	7/19 (37%)
		C2H2 Zn finger	492..512	CDD:275368	7/19 (37%)
		C2H2 Zn finger	520..540	CDD:275368	7/19 (37%)
		C2H2 Zn finger	548..568	CDD:275368	8/19 (42%)
		C2H2 Zn finger	576..596	CDD:275368	8/17 (47%)
		C2H2 Zn finger	604..624	CDD:275368
		C2H2 Zn finger	632..652	CDD:275368
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	0	0.000