Protein Alignment CG12605 and ZSCAN21

DIOPT Version :10

• Sequence 1: NP_647845.2
• Gene: CG12605 / 38468
• FlyBaseID: FBgn0035481
• Length: 619
• Species: Drosophila melanogaster
• Sequence 2: NP_666019.1
• Gene: ZSCAN21 / 7589
• HGNCID: 13104
• Length: 473
• Species: Homo sapiens
• Alignment Length: 490
• Identity: 123/490 - (25%)
• Similarity: 195/490 - (39%)
• Gaps: 129/490 - (26%)

  Fly   179 KVIFYAPPASASGSPRQPE----PVALKRERERDK-------EREREKERE---------RDRMR 223
            ||:..||..    .||.|:    |:.:|.|.:.:|       |..|::.|:         |:.:.
Human     4 KVLGMAPVL----GPRPPQEQVGPLMVKVEEKEEKGKYLPSLEMFRQRFRQFGYHDTPGPREALS 64

  Fly   224 EQQLVAATAAASIYRGRSVEETEAAHDLLSLSQSLPPLIPP---------C------VVTIMKQE 273
            :.:::...     :....:...|...:||.|.|.| .::|.         |      .||:::..
Human    65 QLRVLCCE-----WLRPEIHTKEQILELLVLEQFL-TILPQELQAWVQEHCPESAEEAVTLLEDL 123

  Fly   274 QEQL-------------RSPEIQEISNSASSRSPQSTIR---FIGSSSYDLMG-------GSSE- 314
            :.:|             :.|..::||:|.:::...|:::   ...|..|:..|       |..:
Human   124 ERELDEPGHQVSTPPNEQKPVWEKISSSGTAKESPSSMQPQPLETSHKYESWGPLYIQESGEEQE 188

  Fly   315 ------GANNCSPLTPPNSDHSSDVDIDMSSSSESGLQQWGKPNPQQNQQRASALKMCLNMLDGR 373
                  ...:|...|    .|....|....|.:| ||:.........|:..||..:.|:|:.:.:
Human   189 FAQDPRKVRDCRLST----QHEESADEQKGSEAE-GLKGDIISVIIANKPEASLERQCVNLENEK 248

  Fly   374 -TKASKAAAVTKQDRQE-PMQPRPKSAQSNASSGGGPPSEPPENPAASLGHSSSGNGENYAKRKR 436
             ||.....|.:|:.|:. |.:|.|...:...:..|                .:..|..|..|.:|
Human   249 GTKPPLQEAGSKKGRESVPTKPTPGERRYICAECG----------------KAFSNSSNLTKHRR 297

  Fly   437 -----GCYKCCECGKQYATSSNLSRHKQTH---RSLDSQSAK---------------------KC 472
                 ..|.|.:|||.::.||||:.|.:||   |..|.:..|                     :|
Human   298 THTGEKPYVCTKCGKAFSHSSNLTLHYRTHLVDRPYDCKCGKAFGQSSDLLKHQRMHTEEAPYQC 362

  Fly   473 NTCGKAYVSMPALAMHLLTH--KLSHSCDICGKLFSRPWLLQGHLRSHTGEKPYACVHCGKAFAD 535
            ..||||:....:|..|...|  :..:.|:.|||.||:...|..|.|.|||||||.|..|||||..
Human   363 KDCGKAFSGKGSLIRHYRIHTGEKPYQCNECGKSFSQHAGLSSHQRLHTGEKPYKCKECGKAFNH 427

  Fly   536 RSNLRAHMQTHSGDKNFKCHRCNKTFALKSYLNKH 570
            .||...|.:.|:|:|.:.||.|.|||..||.|:||
Human   428 SSNFNKHHRIHTGEKPYWCHHCGKTFCSKSNLSKH 462

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG12605	NP_647845.2	COG5048	283..>561	CDD:227381	89/327 (27%)
		zf-C2H2	439..461	CDD:395048	10/21 (48%)
		C2H2 Zn finger	441..461	CDD:275370	9/19 (47%)
		C2H2 Zn finger	472..492	CDD:275368	7/19 (37%)
		zf-C2H2	496..518	CDD:395048	9/21 (43%)
		C2H2 Zn finger	498..518	CDD:275368	9/19 (47%)
		zf-H2C2_2	511..534	CDD:463886	15/22 (68%)
		zf-C2H2	524..546	CDD:395048	10/21 (48%)
		C2H2 Zn finger	526..546	CDD:275368	9/19 (47%)
		zf-H2C2_2	538..562	CDD:463886	10/23 (43%)
		C2H2 Zn finger	554..571	CDD:275368	11/17 (65%)
ZSCAN21	NP_666019.1	SCAN	42..153	CDD:128708	19/116 (16%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	127..169		6/41 (15%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	244..272		7/27 (26%)
		COG5048	<276..453	CDD:227381	60/192 (31%)
		C2H2 Zn finger	279..299	CDD:275368	5/35 (14%)
		C2H2 Zn finger	307..327	CDD:275368	9/19 (47%)
		C2H2 Zn finger	337..354	CDD:275368	1/16 (6%)
		C2H2 Zn finger	362..382	CDD:275368	7/19 (37%)
		C2H2 Zn finger	390..410	CDD:275368	9/19 (47%)
		C2H2 Zn finger	418..438	CDD:275368	9/19 (47%)
		C2H2 Zn finger	446..466	CDD:275368	11/17 (65%)
		zf-C2H2	446..466	CDD:395048	11/17 (65%)